ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 67/638 145/7206 3.36285965725e-33 ko03030 DNA replication 21/638 38/7206 3.85306916856e-13 ko03015 mRNA surveillance pathway 31/638 93/7206 2.58509149122e-11 ko04080 Neuroactive ligand-receptor interaction 6/638 423/7206 4.62532080176e-11 ko05217 Basal cell carcinoma 25/638 68/7206 2.0561837948e-10 ko04550 Signaling pathways regulating pluripotency of stem cells 40/638 165/7206 2.02454821463e-09 ko04144 Endocytosis 5/638 342/7206 7.17522730916e-09 ko03008 Ribosome biogenesis in eukaryotes 25/638 79/7206 7.57515513244e-09 ko03013 RNA transport 38/638 166/7206 2.78923341079e-08 ko00240 Pyrimidine metabolism 28/638 110/7206 1.86714271943e-07 ko03020 RNA polymerase 13/638 29/7206 3.25504500507e-07 ko04111 Cell cycle - yeast 24/638 90/7206 5.61138194832e-07 ko04020 Calcium signaling pathway 4/638 265/7206 7.10082658418e-07 ko04110 Cell cycle 32/638 145/7206 8.5038972663e-07 ko04921 Oxytocin signaling pathway 2/638 209/7206 1.40891762499e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/638 182/7206 1.75038972079e-06 ko03410 Base excision repair 14/638 38/7206 2.0474341447e-06 ko04330 Notch signaling pathway 18/638 62/7206 3.94284377921e-06 ko04310 Wnt signaling pathway 35/638 181/7206 7.439119499e-06 ko05012 Parkinson's disease 1/638 155/7206 1.90630390366e-05 ko05224 Breast cancer 33/638 174/7206 2.00801539354e-05 ko04723 Retrograde endocannabinoid signaling 2/638 175/7206 2.04977569631e-05 ko03420 Nucleotide excision repair 14/638 46/7206 2.60090588931e-05 ko04340 Hedgehog signaling pathway 16/638 58/7206 2.75419670898e-05 ko04072 Phospholipase D signaling pathway 3/638 197/7206 3.15613868972e-05 ko03050 Proteasome 15/638 54/7206 4.47878786428e-05 ko03430 Mismatch repair 9/638 22/7206 5.47199491523e-05 ko05202 Transcriptional misregulation in cancer 34/638 188/7206 6.62601474307e-05 ko04726 Serotonergic synapse 1/638 137/7206 9.23430324061e-05 ko04950 Maturity onset diabetes of the young 10/638 29/7206 0.000116658873981 ko04062 Chemokine signaling pathway 4/638 201/7206 0.000118131153151 ko04390 Hippo signaling pathway 33/638 188/7206 0.000120463032019 ko04141 Protein processing in endoplasmic reticulum 4/638 184/7206 0.000321004554151 ko05169 Epstein-Barr virus infection 34/638 206/7206 0.000398010787861 ko04621 NOD-like receptor signaling pathway 3/638 157/7206 0.000543758795575 ko04022 cGMP-PKG signaling pathway 6/638 216/7206 0.000558652282952 ko04725 Cholinergic synapse 3/638 160/7206 0.000572351687086 ko04070 Phosphatidylinositol signaling system 1/638 112/7206 0.000613841488319 ko04727 GABAergic synapse 1/638 110/7206 0.000960631866502 ko04113 Meiosis - yeast 15/638 70/7206 0.000982704588898 ko00230 Purine metabolism 31/638 194/7206 0.00116443847723 ko04712 Circadian rhythm - plant 4/638 7/7206 0.00171395385822 ko04024 cAMP signaling pathway 11/638 279/7206 0.00172881786883 ko04971 Gastric acid secretion 1/638 98/7206 0.00195515900352 ko04350 TGF-beta signaling pathway 19/638 103/7206 0.00227334097893 ko04970 Salivary secretion 1/638 95/7206 0.00293237536859 ko04713 Circadian entrainment 3/638 136/7206 0.00324037330002 ko04270 Vascular smooth muscle contraction 4/638 154/7206 0.00359760919641 ko04139 Mitophagy - yeast 9/638 37/7206 0.0040940739175 ko04662 B cell receptor signaling pathway 1/638 88/7206 0.00421190716022 ko04920 Adipocytokine signaling pathway 1/638 89/7206 0.00421838544065 ko00562 Inositol phosphate metabolism 1/638 89/7206 0.00421838544065 ko05205 Proteoglycans in cancer 38/638 271/7206 0.00428882022679 ko01200 Carbon metabolism 3/638 128/7206 0.00443358848499 ko04922 Glucagon signaling pathway 3/638 128/7206 0.00443358848499 ko03010 Ribosome 3/638 129/7206 0.00443908111247 ko04915 Estrogen signaling pathway 3/638 131/7206 0.00454040379916 ko04925 Aldosterone synthesis and secretion 2/638 105/7206 0.00815020956506 ko05166 HTLV-I infection 39/638 292/7206 0.00830618854929 ko04912 GnRH signaling pathway 3/638 122/7206 0.00901509491054 ko04610 Complement and coagulation cascades 1/638 79/7206 0.00902819080089 ko04060 Cytokine-cytokine receptor interaction 7/638 191/7206 0.00909378854025 ko04910 Insulin signaling pathway 6/638 172/7206 0.00920596682132 ko05100 Bacterial invasion of epithelial cells 2/638 99/7206 0.0113017937904 ko04720 Long-term potentiation 2/638 99/7206 0.0113017937904 ko04630 Jak-STAT signaling pathway 4/638 132/7206 0.0126877510181 ko04923 Regulation of lipolysis in adipocytes 1/638 77/7206 0.0135185461139 ko05120 Epithelial cell signaling in Helicobacter pylori infection 2/638 92/7206 0.0158160232162 ko04071 Sphingolipid signaling pathway 6/638 162/7206 0.0165745918982 ko04972 Pancreatic secretion 3/638 111/7206 0.0171844588548 ko04066 HIF-1 signaling pathway 4/638 123/7206 0.0238773419834 ko04728 Dopaminergic synapse 8/638 185/7206 0.0252009314673 ko05160 Hepatitis C 6/638 153/7206 0.0296127738617 ko04931 Insulin resistance 5/638 137/7206 0.0317462429227 ko04911 Insulin secretion 4/638 117/7206 0.0323780549049 ko04010 MAPK signaling pathway 18/638 321/7206 0.0345670796402 ko04611 Platelet activation 7/638 163/7206 0.0358331693995 ko05167 Kaposi's sarcoma-associated herpesvirus infection 9/638 191/7206 0.038583721266 ko04742 Taste transduction 1/638 61/7206 0.0406573215979 ko04913 Ovarian steroidogenesis 1/638 63/7206 0.0414366872569 ko00600 Sphingolipid metabolism 1/638 63/7206 0.0414366872569 ko04371 Apelin signaling pathway 8/638 177/7206 0.0430725384296 ko04217 Necroptosis 8/638 178/7206 0.0434668253275 ko04612 Antigen processing and presentation 12/638 77/7206 0.0435935169244 ko05414 Dilated cardiomyopathy 4/638 112/7206 0.0438979785011 ko04976 Bile secretion 2/638 80/7206 0.0451981250877 ko05211 Renal cell carcinoma 3/638 96/7206 0.0453243943231 ko04260 Cardiac muscle contraction 3/638 98/7206 0.0461817169257 ko04722 Neurotrophin signaling pathway 7/638 160/7206 0.0472767055182 ko05200 Pathways in cancer 56/638 492/7206 0.0479974710603