ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	155/781	423/7206	2.32036384784e-48
ko04724	Glutamatergic synapse	71/781	152/7206	9.56421187402e-30
ko05033	Nicotine addiction	42/781	56/7206	1.41391541922e-29
ko04713	Circadian entrainment	56/781	136/7206	2.33864786628e-20
ko04728	Dopaminergic synapse	66/781	185/7206	8.66972402672e-20
ko05032	Morphine addiction	49/781	110/7206	1.05071307232e-19
ko04723	Retrograde endocannabinoid signaling	61/781	175/7206	8.63700980991e-18
ko04727	GABAergic synapse	45/781	110/7206	1.90188415919e-16
ko04024	cAMP signaling pathway	78/781	279/7206	4.45311667922e-16
ko04725	Cholinergic synapse	53/781	160/7206	1.54886767538e-14
ko04742	Taste transduction	29/781	61/7206	4.61722944242e-13
ko04726	Serotonergic synapse	46/781	137/7206	5.15280755667e-13
ko04721	Synaptic vesicle cycle	33/781	80/7206	1.62743113974e-12
ko04020	Calcium signaling pathway	68/781	265/7206	4.58293111171e-12
ko05031	Amphetamine addiction	34/781	91/7206	2.0696583717e-11
ko04921	Oxytocin signaling pathway	56/781	209/7206	7.61820582261e-11
ko04911	Insulin secretion	37/781	117/7206	7.15899114777e-10
ko04720	Long-term potentiation	32/781	99/7206	5.61658763377e-09
ko04970	Salivary secretion	31/781	95/7206	7.53814110595e-09
ko04261	Adrenergic signaling in cardiomyocytes	49/781	205/7206	6.43020551709e-08
ko05030	Cocaine addiction	25/781	73/7206	7.37111840744e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	25/781	74/7206	1.00089509066e-07
ko04744	Phototransduction	16/781	36/7206	2.81373282578e-07
ko04730	Long-term depression	24/781	78/7206	1.26538561471e-06
ko05164	Influenza A	2/781	167/7206	1.70123282675e-06
ko04740	Olfactory transduction	24/781	80/7206	2.10017182119e-06
ko03040	Spliceosome	1/781	145/7206	2.1045222605e-06
ko05203	Viral carcinogenesis	9/781	277/7206	4.2159990465e-06
ko04060	Cytokine-cytokine receptor interaction	4/781	191/7206	8.1713916275e-06
ko05168	Herpes simplex infection	4/781	182/7206	1.63322952106e-05
ko05162	Measles	1/781	120/7206	2.24942434844e-05
ko04120	Ubiquitin mediated proteolysis	2/781	138/7206	3.92567078873e-05
ko04925	Aldosterone synthesis and secretion	26/781	105/7206	4.2407137241e-05
ko04971	Gastric acid secretion	25/781	98/7206	4.24794553544e-05
ko04514	Cell adhesion molecules (CAMs)	30/781	130/7206	4.60703989568e-05
ko04745	Phototransduction - fly	13/781	38/7206	0.00010535677505
ko04010	MAPK signaling pathway	57/781	321/7206	0.000145085879352
ko05322	Systemic lupus erythematosus	4/781	151/7206	0.000286877279456
ko04924	Renin secretion	21/781	86/7206	0.000299958378959
ko04972	Pancreatic secretion	25/781	111/7206	0.000304323251312
ko05166	HTLV-I infection	14/781	292/7206	0.000334013339872
ko04260	Cardiac muscle contraction	23/781	98/7206	0.000402360035796
ko04621	NOD-like receptor signaling pathway	5/781	157/7206	0.000641032558032
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/781	79/7206	0.000708861288706
ko04150	mTOR signaling pathway	7/781	184/7206	0.00070926654267
ko03013	RNA transport	6/781	166/7206	0.000948636186081
ko04022	cGMP-PKG signaling pathway	39/781	216/7206	0.00116625654166
ko05169	Epstein-Barr virus infection	9/781	206/7206	0.00131066823994
ko04550	Signaling pathways regulating pluripotency of stem cells	6/781	165/7206	0.00133696013274
ko04540	Gap junction	26/781	128/7206	0.00136913821401
ko04630	Jak-STAT signaling pathway	4/781	132/7206	0.00162807324297
ko05161	Hepatitis B	7/781	173/7206	0.00181834763499
ko04510	Focal adhesion	12/781	240/7206	0.00202039054116
ko04014	Ras signaling pathway	47/781	279/7206	0.00215816969446
ko04612	Antigen processing and presentation	1/781	77/7206	0.00263285463895
ko05205	Proteoglycans in cancer	15/781	271/7206	0.00269434253391
ko05215	Prostate cancer	3/781	111/7206	0.00295394687736
ko04214	Apoptosis - fly	1/781	72/7206	0.00386420847044
ko04141	Protein processing in endoplasmic reticulum	9/781	184/7206	0.00557317988459
ko04350	TGF-beta signaling pathway	3/781	103/7206	0.00587860767823
ko04110	Cell cycle	6/781	145/7206	0.00638800111793
ko04750	Inflammatory mediator regulation of TRP channels	23/781	122/7206	0.00749426952138
ko04626	Plant-pathogen interaction	6/781	18/7206	0.0093908612978
ko04360	Axon guidance	38/781	233/7206	0.00971154597962
ko04964	Proximal tubule bicarbonate reclamation	8/781	29/7206	0.00991730272138
ko04072	Phospholipase D signaling pathway	33/781	197/7206	0.010152030279
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/781	59/7206	0.0103410138362
ko04610	Complement and coagulation cascades	2/781	79/7206	0.0103719600778
ko03008	Ribosome biogenesis in eukaryotes	2/781	79/7206	0.0103719600778
ko04064	NF-kappa B signaling pathway	3/781	96/7206	0.0118233705408
ko04330	Notch signaling pathway	1/781	62/7206	0.0123898821899
ko05140	Leishmaniasis	2/781	75/7206	0.0148432581816
ko01524	Platinum drug resistance	2/781	76/7206	0.0148611197131
ko05010	Alzheimer's disease	33/781	202/7206	0.0153528862233
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/781	182/7206	0.0154263716008
ko04146	Peroxisome	3/781	89/7206	0.0160539440154
ko04668	TNF signaling pathway	5/781	120/7206	0.0165654740213
ko05200	Pathways in cancer	38/781	492/7206	0.0197673233884
ko04070	Phosphatidylinositol signaling system	20/781	112/7206	0.0211775095886
ko04915	Estrogen signaling pathway	23/781	131/7206	0.0218325283327
ko04140	Autophagy - animal	9/781	164/7206	0.0219559468576
ko05220	Chronic myeloid leukemia	3/781	85/7206	0.0224256541084
ko00280	Valine, leucine and isoleucine degradation	1/781	54/7206	0.0265014109447
ko00480	Glutathione metabolism	1/781	55/7206	0.0268417809539
ko00240	Pyrimidine metabolism	5/781	110/7206	0.029601115004
ko05211	Renal cell carcinoma	4/781	96/7206	0.0308069986375
ko05034	Alcoholism	36/781	238/7206	0.0340084679783
ko04210	Apoptosis	11/781	180/7206	0.0383929261271
ko04930	Type II diabetes mellitus	11/781	54/7206	0.0430132408563
ko05414	Dilated cardiomyopathy	19/781	112/7206	0.0449624234103
ko05230	Central carbon metabolism in cancer	3/781	81/7206	0.0449708392794