ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/1107	423/7206	1.85122426201e-45
ko04724	Glutamatergic synapse	89/1107	152/7206	4.6349744467e-35
ko05033	Nicotine addiction	46/1107	56/7206	1.25453062585e-28
ko05032	Morphine addiction	65/1107	110/7206	3.80801290202e-26
ko04727	GABAergic synapse	64/1107	110/7206	3.13944162954e-25
ko04713	Circadian entrainment	72/1107	136/7206	8.31189816512e-25
ko04728	Dopaminergic synapse	82/1107	185/7206	1.56998927934e-21
ko04725	Cholinergic synapse	71/1107	160/7206	8.25284469345e-19
ko04723	Retrograde endocannabinoid signaling	75/1107	175/7206	9.86394474727e-19
ko04721	Synaptic vesicle cycle	46/1107	80/7206	3.59534972657e-18
ko04911	Insulin secretion	55/1107	117/7206	3.44409471909e-16
ko04020	Calcium signaling pathway	91/1107	265/7206	5.31753224161e-15
ko04024	cAMP signaling pathway	93/1107	279/7206	2.72989399651e-14
ko04742	Taste transduction	35/1107	61/7206	4.34867240962e-14
ko04726	Serotonergic synapse	57/1107	137/7206	7.77713701108e-14
ko04720	Long-term potentiation	45/1107	99/7206	8.02970540141e-13
ko05031	Amphetamine addiction	42/1107	91/7206	2.50463245831e-12
ko04744	Phototransduction	24/1107	36/7206	4.63174547581e-12
ko04921	Oxytocin signaling pathway	70/1107	209/7206	3.39146128017e-11
ko04925	Aldosterone synthesis and secretion	41/1107	105/7206	2.56867626e-09
ko04970	Salivary secretion	38/1107	95/7206	4.45972574196e-09
ko03040	Spliceosome	2/1107	145/7206	1.6339144151e-08
ko03010	Ribosome	1/1107	129/7206	1.76362410269e-08
ko04261	Adrenergic signaling in cardiomyocytes	63/1107	205/7206	1.81673693111e-08
ko04971	Gastric acid secretion	37/1107	98/7206	4.42322050084e-08
ko05030	Cocaine addiction	28/1107	73/7206	1.3349527704e-06
ko04730	Long-term depression	29/1107	78/7206	1.83631008045e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1107	74/7206	1.83768907164e-06
ko04022	cGMP-PKG signaling pathway	60/1107	216/7206	1.96877220384e-06
ko05322	Systemic lupus erythematosus	5/1107	151/7206	3.11476988233e-06
ko04514	Cell adhesion molecules (CAMs)	41/1107	130/7206	3.13623416881e-06
ko05168	Herpes simplex infection	8/1107	182/7206	3.41835274383e-06
ko04010	MAPK signaling pathway	80/1107	321/7206	5.26182965352e-06
ko05203	Viral carcinogenesis	18/1107	277/7206	8.00015196057e-06
ko04740	Olfactory transduction	28/1107	80/7206	1.21389724033e-05
ko04972	Pancreatic secretion	35/1107	111/7206	1.4566098347e-05
ko04745	Phototransduction - fly	17/1107	38/7206	1.51595868219e-05
ko04060	Cytokine-cytokine receptor interaction	10/1107	191/7206	1.55926554382e-05
ko04070	Phosphatidylinositol signaling system	35/1107	112/7206	2.68812310485e-05
ko03013	RNA transport	8/1107	166/7206	2.74969034642e-05
ko04110	Cell cycle	6/1107	145/7206	3.36728826207e-05
ko04141	Protein processing in endoplasmic reticulum	10/1107	184/7206	4.27143632807e-05
ko04621	NOD-like receptor signaling pathway	8/1107	157/7206	7.59536181646e-05
ko05164	Influenza A	9/1107	167/7206	7.88740981748e-05
ko04540	Gap junction	37/1107	128/7206	9.34384886301e-05
ko05162	Measles	5/1107	120/7206	0.000168660126106
ko04750	Inflammatory mediator regulation of TRP channels	35/1107	122/7206	0.000183718769711
ko04966	Collecting duct acid secretion	12/1107	26/7206	0.000193085891362
ko04014	Ras signaling pathway	66/1107	279/7206	0.000244738966383
ko03008	Ribosome biogenesis in eukaryotes	2/1107	79/7206	0.000412490817924
ko04630	Jak-STAT signaling pathway	7/1107	132/7206	0.0005481739381
ko04612	Antigen processing and presentation	2/1107	77/7206	0.000628699128298
ko04360	Axon guidance	55/1107	233/7206	0.000815750790296
ko04072	Phospholipase D signaling pathway	48/1107	197/7206	0.000857830802705
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1107	79/7206	0.00152824395295
ko05169	Epstein-Barr virus infection	16/1107	206/7206	0.00157497236982
ko04710	Circadian rhythm	15/1107	43/7206	0.00198667893552
ko04610	Complement and coagulation cascades	3/1107	79/7206	0.00238669802487
ko04924	Renin secretion	24/1107	86/7206	0.00240065835347
ko05110	Vibrio cholerae infection	19/1107	63/7206	0.00248200651288
ko04964	Proximal tubule bicarbonate reclamation	11/1107	29/7206	0.00256096074797
ko04120	Ubiquitin mediated proteolysis	9/1107	138/7206	0.0026068343405
ko04915	Estrogen signaling pathway	33/1107	131/7206	0.00307698329804
ko04626	Plant-pathogen interaction	8/1107	18/7206	0.00313319446754
ko04973	Carbohydrate digestion and absorption	14/1107	42/7206	0.00379328107733
ko04064	NF-kappa B signaling pathway	5/1107	96/7206	0.00386017521226
ko04330	Notch signaling pathway	2/1107	62/7206	0.00408696049672
ko04922	Glucagon signaling pathway	32/1107	128/7206	0.00411806067244
ko04260	Cardiac muscle contraction	26/1107	98/7206	0.00425801756489
ko05161	Hepatitis B	14/1107	173/7206	0.0053534331965
ko04371	Apelin signaling pathway	41/1107	177/7206	0.00576688617219
ko03420	Nucleotide excision repair	1/1107	46/7206	0.00692916445233
ko04146	Peroxisome	5/1107	89/7206	0.00725169199911
ko04912	GnRH signaling pathway	30/1107	122/7206	0.00732752088468
ko04960	Aldosterone-regulated sodium reabsorption	13/1107	41/7206	0.00759956289479
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1107	59/7206	0.0095746293976
ko05205	Proteoglycans in cancer	27/1107	271/7206	0.00995019806067
ko03022	Basal transcription factors	1/1107	44/7206	0.0104282985309
ko05144	Malaria	1/1107	45/7206	0.0108175885869
ko00280	Valine, leucine and isoleucine degradation	2/1107	54/7206	0.0126334788714
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1107	14/7206	0.0128536487799
ko05140	Leishmaniasis	4/1107	75/7206	0.014413558937
ko00240	Pyrimidine metabolism	8/1107	110/7206	0.0157956094602
ko05414	Dilated cardiomyopathy	27/1107	112/7206	0.0164533181281
ko04270	Vascular smooth muscle contraction	35/1107	154/7206	0.0169761772356
ko05145	Toxoplasmosis	10/1107	126/7206	0.017424857633
ko04510	Focal adhesion	24/1107	240/7206	0.0177101406721
ko05131	Shigellosis	5/1107	82/7206	0.019466201442
ko04622	RIG-I-like receptor signaling pathway	3/1107	62/7206	0.0197575951549
ko04214	Apoptosis - fly	4/1107	72/7206	0.0199222009639
ko05166	HTLV-I infection	31/1107	292/7206	0.0202303689631
ko04930	Type II diabetes mellitus	15/1107	54/7206	0.0205997008549
ko04658	Th1 and Th2 cell differentiation	7/1107	96/7206	0.0227135426392
ko00630	Glyoxylate and dicarboxylate metabolism	1/1107	38/7206	0.0229524296435
ko03410	Base excision repair	1/1107	38/7206	0.0229524296435
ko04918	Thyroid hormone synthesis	21/1107	86/7206	0.023874974435
ko04657	IL-17 signaling pathway	6/1107	87/7206	0.0243825031846
ko05133	Pertussis	6/1107	87/7206	0.0243825031846
ko05222	Small cell lung cancer	6/1107	89/7206	0.0250505202671
ko00260	Glycine, serine and threonine metabolism	2/1107	48/7206	0.0262576301576
ko04217	Necroptosis	17/1107	178/7206	0.0270360707705
ko04976	Bile secretion	20/1107	80/7206	0.0272772128029
ko03320	PPAR signaling pathway	4/1107	69/7206	0.0274550088606
ko05231	Choline metabolism in cancer	30/1107	134/7206	0.0288613265328
ko04114	Oocyte meiosis	31/1107	139/7206	0.0314971244639
ko04975	Fat digestion and absorption	1/1107	35/7206	0.0340735600693
ko00500	Starch and sucrose metabolism	1/1107	35/7206	0.0340735600693
ko05016	Huntington's disease	22/1107	215/7206	0.0343142387954
ko04115	p53 signaling pathway	5/1107	74/7206	0.03523451221
ko04711	Circadian rhythm - fly	5/1107	13/7206	0.0373397390334
ko00562	Inositol phosphate metabolism	21/1107	89/7206	0.0375261030068
ko00071	Fatty acid degradation	2/1107	45/7206	0.0377329856962
ko05321	Inflammatory bowel disease (IBD)	3/1107	56/7206	0.038703818163
ko05214	Glioma	19/1107	79/7206	0.040117040829
ko05202	Transcriptional misregulation in cancer	19/1107	188/7206	0.0405962761936
ko04015	Rap1 signaling pathway	55/1107	278/7206	0.0415626025045
ko04210	Apoptosis	18/1107	180/7206	0.0461121611541
ko04062	Chemokine signaling pathway	41/1107	201/7206	0.0474675648609