ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	33/807	56/7206	5.78092009299e-18
ko04080	Neuroactive ligand-receptor interaction	101/807	423/7206	3.08818144206e-14
ko04721	Synaptic vesicle cycle	34/807	80/7206	6.8041707268e-13
ko04728	Dopaminergic synapse	55/807	185/7206	3.04737588593e-12
ko04724	Glutamatergic synapse	48/807	152/7206	7.00874394826e-12
ko04360	Axon guidance	57/807	233/7206	8.20200912261e-09
ko04514	Cell adhesion molecules (CAMs)	38/807	130/7206	1.27079194443e-08
ko04727	GABAergic synapse	34/807	110/7206	1.59105083898e-08
ko05032	Morphine addiction	33/807	110/7206	5.82882524473e-08
ko04723	Retrograde endocannabinoid signaling	45/807	175/7206	6.25266590095e-08
ko04713	Circadian entrainment	37/807	136/7206	2.37906798092e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	24/807	74/7206	7.85922287033e-07
ko05030	Cocaine addiction	23/807	73/7206	2.35024167415e-06
ko04725	Cholinergic synapse	38/807	160/7206	5.25608079906e-06
ko05203	Viral carcinogenesis	10/807	277/7206	6.04155235572e-06
ko03040	Spliceosome	2/807	145/7206	1.21780326995e-05
ko04024	cAMP signaling pathway	55/807	279/7206	2.47679413421e-05
ko04120	Ubiquitin mediated proteolysis	2/807	138/7206	2.67385041186e-05
ko04911	Insulin secretion	29/807	117/7206	3.76164280294e-05
ko03013	RNA transport	4/807	166/7206	4.82703610526e-05
ko05031	Amphetamine addiction	24/807	91/7206	6.0266951339e-05
ko04060	Cytokine-cytokine receptor interaction	6/807	191/7206	6.41747791757e-05
ko04726	Serotonergic synapse	31/807	137/7206	9.86682749232e-05
ko04261	Adrenergic signaling in cardiomyocytes	42/807	205/7206	0.000105066279383
ko04974	Protein digestion and absorption	24/807	96/7206	0.000115034018232
ko04340	Hedgehog signaling pathway	17/807	58/7206	0.000133992873501
ko04950	Maturity onset diabetes of the young	11/807	29/7206	0.000167171431475
ko05168	Herpes simplex infection	6/807	182/7206	0.000180698328735
ko05322	Systemic lupus erythematosus	4/807	151/7206	0.000201017036917
ko04611	Platelet activation	5/807	163/7206	0.000225742140465
ko05162	Measles	3/807	120/7206	0.000681444837633
ko03018	RNA degradation	1/807	84/7206	0.000791522103066
ko04140	Autophagy - animal	6/807	164/7206	0.00096110926471
ko04550	Signaling pathways regulating pluripotency of stem cells	33/807	165/7206	0.000989663250034
ko00564	Glycerophospholipid metabolism	2/807	99/7206	0.00112909775949
ko04141	Protein processing in endoplasmic reticulum	8/807	184/7206	0.00130448252297
ko04744	Phototransduction	11/807	36/7206	0.0013916285736
ko01200	Carbon metabolism	4/807	128/7206	0.00160379325543
ko04010	MAPK signaling pathway	54/807	321/7206	0.00196805509534
ko05224	Breast cancer	33/807	174/7206	0.00213788892976
ko04211	Longevity regulating pathway	4/807	123/7206	0.00222938910003
ko00010	Glycolysis / Gluconeogenesis	1/807	74/7206	0.00257206972723
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/807	14/7206	0.00263048289788
ko04742	Taste transduction	15/807	61/7206	0.00309090131997
ko04260	Cardiac muscle contraction	21/807	98/7206	0.00311266243797
ko05217	Basal cell carcinoma	16/807	68/7206	0.00313226486272
ko04964	Proximal tubule bicarbonate reclamation	9/807	29/7206	0.00333482099919
ko04932	Non-alcoholic fatty liver disease (NAFLD)	9/807	182/7206	0.00413214385867
ko04621	NOD-like receptor signaling pathway	7/807	157/7206	0.00451043441041
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/807	59/7206	0.00556331733157
ko05164	Influenza A	8/807	167/7206	0.00586561803106
ko04138	Autophagy - yeast	2/807	81/7206	0.00714167523462
ko04064	NF-kappa B signaling pathway	3/807	96/7206	0.00817790857669
ko04913	Ovarian steroidogenesis	1/807	63/7206	0.00826487351645
ko03008	Ribosome biogenesis in eukaryotes	2/807	79/7206	0.0105602062225
ko04978	Mineral absorption	10/807	40/7206	0.0108676437767
ko04914	Progesterone-mediated oocyte maturation	4/807	104/7206	0.0117272140021
ko01524	Platinum drug resistance	2/807	76/7206	0.015430817527
ko04213	Longevity regulating pathway - multiple species	3/807	86/7206	0.0158764127291
ko04512	ECM-receptor interaction	16/807	79/7206	0.0177939114554
ko00520	Amino sugar and nucleotide sugar metabolism	1/807	55/7206	0.0178818573588
ko04966	Collecting duct acid secretion	7/807	26/7206	0.0210111611311
ko00240	Pyrimidine metabolism	5/807	110/7206	0.0216660224568
ko04214	Apoptosis - fly	2/807	72/7206	0.0217995663633
ko04540	Gap junction	23/807	128/7206	0.0223207631065
ko05146	Amoebiasis	4/807	99/7206	0.0229241265139
ko05202	Transcriptional misregulation in cancer	31/807	188/7206	0.0253819024937
ko00280	Valine, leucine and isoleucine degradation	1/807	54/7206	0.0270626235873
ko04217	Necroptosis	11/807	178/7206	0.0297979370812
ko04151	PI3K-Akt signaling pathway	57/807	390/7206	0.0316617799168
ko00260	Glycine, serine and threonine metabolism	1/807	48/7206	0.0382988310626
ko00380	Tryptophan metabolism	1/807	50/7206	0.0392057675586
ko04146	Peroxisome	4/807	89/7206	0.0415868872411
ko00600	Sphingolipid metabolism	2/807	63/7206	0.0425601165722
ko04976	Bile secretion	15/807	80/7206	0.0468148204468
ko04970	Salivary secretion	17/807	95/7206	0.0475990612066
ko04910	Insulin signaling pathway	11/807	172/7206	0.0489654157287