ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 154/840 423/7206 2.67298031998e-43 ko04724 Glutamatergic synapse 76/840 152/7206 3.74329234992e-32 ko05033 Nicotine addiction 42/840 56/7206 2.87738852024e-28 ko05032 Morphine addiction 57/840 110/7206 2.40593859233e-25 ko04727 GABAergic synapse 54/840 110/7206 1.34042593073e-22 ko04728 Dopaminergic synapse 69/840 185/7206 4.26352094384e-20 ko04713 Circadian entrainment 56/840 136/7206 7.73085399471e-19 ko04723 Retrograde endocannabinoid signaling 64/840 175/7206 3.3651988906e-18 ko04725 Cholinergic synapse 60/840 160/7206 9.75669261268e-18 ko04024 cAMP signaling pathway 80/840 279/7206 3.0861414542e-15 ko04911 Insulin secretion 46/840 117/7206 9.0500101274e-15 ko04020 Calcium signaling pathway 71/840 265/7206 6.06415554772e-12 ko04721 Synaptic vesicle cycle 33/840 80/7206 1.24395016177e-11 ko04261 Adrenergic signaling in cardiomyocytes 58/840 205/7206 4.56779176714e-11 ko04921 Oxytocin signaling pathway 58/840 209/7206 9.59964864364e-11 ko04726 Serotonergic synapse 44/840 137/7206 1.09727690631e-10 ko04742 Taste transduction 27/840 61/7206 1.34136637242e-10 ko05031 Amphetamine addiction 33/840 91/7206 7.24398906812e-10 ko04720 Long-term potentiation 33/840 99/7206 8.56144422672e-09 ko05030 Cocaine addiction 27/840 73/7206 1.58720646623e-08 ko04010 MAPK signaling pathway 69/840 321/7206 2.64314941876e-07 ko03040 Spliceosome 1/840 145/7206 5.5835101564e-07 ko04970 Salivary secretion 29/840 95/7206 5.7901559537e-07 ko05203 Viral carcinogenesis 9/840 277/7206 7.35390995674e-07 ko04514 Cell adhesion molecules (CAMs) 35/840 130/7206 1.24782763894e-06 ko04072 Phospholipase D signaling pathway 46/840 197/7206 2.57516533186e-06 ko04972 Pancreatic secretion 31/840 111/7206 2.98355930898e-06 ko04925 Aldosterone synthesis and secretion 29/840 105/7206 7.5434617724e-06 ko04360 Axon guidance 50/840 233/7206 1.55071547718e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 22/840 74/7206 2.12070903354e-05 ko04730 Long-term depression 22/840 78/7206 5.21678161808e-05 ko05168 Herpes simplex infection 6/840 182/7206 8.86819052398e-05 ko05322 Systemic lupus erythematosus 4/840 151/7206 9.30181216276e-05 ko03013 RNA transport 5/840 166/7206 0.000113534387088 ko04744 Phototransduction 13/840 36/7206 0.000118316685368 ko04971 Gastric acid secretion 25/840 98/7206 0.000170911905197 ko04022 cGMP-PKG signaling pathway 44/840 216/7206 0.000209837125219 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/840 79/7206 0.000246820258216 ko05164 Influenza A 6/840 167/7206 0.000339171184546 ko04260 Cardiac muscle contraction 24/840 98/7206 0.000342956559951 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/840 14/7206 0.000466959555926 ko04915 Estrogen signaling pathway 29/840 131/7206 0.000508989905942 ko04060 Cytokine-cytokine receptor interaction 8/840 191/7206 0.000518299641746 ko04110 Cell cycle 5/840 145/7206 0.0006119243509 ko03008 Ribosome biogenesis in eukaryotes 1/840 79/7206 0.00115893255722 ko04120 Ubiquitin mediated proteolysis 5/840 138/7206 0.00119712266825 ko05414 Dilated cardiomyopathy 25/840 112/7206 0.00148340998686 ko04070 Phosphatidylinositol signaling system 25/840 112/7206 0.00148340998686 ko05205 Proteoglycans in cancer 16/840 271/7206 0.00187521895485 ko04540 Gap junction 27/840 128/7206 0.00194248525205 ko04740 Olfactory transduction 19/840 80/7206 0.00225129279303 ko04141 Protein processing in endoplasmic reticulum 9/840 184/7206 0.0022780964692 ko04621 NOD-like receptor signaling pathway 7/840 157/7206 0.00238439959834 ko04640 Hematopoietic cell lineage 1/840 64/7206 0.00549726054364 ko05162 Measles 5/840 120/7206 0.0061297017571 ko00240 Pyrimidine metabolism 4/840 110/7206 0.00623676561232 ko04612 Antigen processing and presentation 2/840 77/7206 0.00699851884001 ko04350 TGF-beta signaling pathway 4/840 103/7206 0.00832892460847 ko04930 Type II diabetes mellitus 13/840 54/7206 0.00897841069357 ko04750 Inflammatory mediator regulation of TRP channels 24/840 122/7206 0.00960375419387 ko04014 Ras signaling pathway 47/840 279/7206 0.00981688976388 ko04745 Phototransduction - fly 10/840 38/7206 0.00982263010283 ko05140 Leishmaniasis 2/840 75/7206 0.0101671843139 ko04976 Bile secretion 17/840 80/7206 0.0127721839717 ko05231 Choline metabolism in cancer 25/840 134/7206 0.0143634834756 ko05169 Epstein-Barr virus infection 13/840 206/7206 0.0147616458227 ko04964 Proximal tubule bicarbonate reclamation 8/840 29/7206 0.0151122268597 ko04064 NF-kappa B signaling pathway 4/840 96/7206 0.015946067845 ko05410 Hypertrophic cardiomyopathy (HCM) 20/840 100/7206 0.0170205833542 ko04371 Apelin signaling pathway 31/840 177/7206 0.0175577086558 ko04071 Sphingolipid signaling pathway 29/840 162/7206 0.0178563206876 ko00480 Glutathione metabolism 1/840 55/7206 0.017986825711 ko05321 Inflammatory bowel disease (IBD) 1/840 56/7206 0.0185992633239 ko03320 PPAR signaling pathway 2/840 69/7206 0.0213747063872 ko05034 Alcoholism 39/840 238/7206 0.0238867507954 ko04966 Collecting duct acid secretion 7/840 26/7206 0.0256718209644 ko04924 Renin secretion 17/840 86/7206 0.0264274453916 ko04146 Peroxisome 4/840 89/7206 0.0301020754652 ko05016 Huntington's disease 15/840 215/7206 0.0302888376944 ko03420 Nucleotide excision repair 1/840 46/7206 0.037844443596 ko00260 Glycine, serine and threonine metabolism 1/840 48/7206 0.0386934395136 ko04510 Focal adhesion 18/840 240/7206 0.0405119858006 ko05133 Pertussis 4/840 87/7206 0.0416688422593 ko04214 Apoptosis - fly 3/840 72/7206 0.0423104705542 ko00330 Arginine and proline metabolism 2/840 61/7206 0.0423758126917 ko04217 Necroptosis 12/840 178/7206 0.0432456478731 ko05110 Vibrio cholerae infection 13/840 63/7206 0.0447953801267 ko04722 Neurotrophin signaling pathway 27/840 160/7206 0.0453595725476 ko04923 Regulation of lipolysis in adipocytes 15/840 77/7206 0.0465551232191