ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 35/283 152/7206 4.28898620367e-18 ko04728 Dopaminergic synapse 33/283 185/7206 1.1558893663e-13 ko05033 Nicotine addiction 19/283 56/7206 1.22071390072e-13 ko04723 Retrograde endocannabinoid signaling 28/283 175/7206 1.39442080412e-10 ko05031 Amphetamine addiction 20/283 91/7206 2.06212333599e-10 ko04713 Circadian entrainment 24/283 136/7206 3.92418004888e-10 ko04727 GABAergic synapse 19/283 110/7206 4.0626865055e-08 ko04720 Long-term potentiation 18/283 99/7206 4.09153931804e-08 ko04020 Calcium signaling pathway 30/283 265/7206 1.28387839105e-07 ko05032 Morphine addiction 18/283 110/7206 2.19390677969e-07 ko04080 Neuroactive ligand-receptor interaction 39/283 423/7206 4.27225968134e-07 ko04911 Insulin secretion 18/283 117/7206 5.69711858766e-07 ko05030 Cocaine addiction 14/283 73/7206 6.91052864738e-07 ko04024 cAMP signaling pathway 29/283 279/7206 1.28431180787e-06 ko04261 Adrenergic signaling in cardiomyocytes 24/283 205/7206 1.36165923057e-06 ko04915 Estrogen signaling pathway 17/283 131/7206 1.27410247221e-05 ko04925 Aldosterone synthesis and secretion 15/283 105/7206 1.29182236493e-05 ko04921 Oxytocin signaling pathway 22/283 209/7206 2.13541842238e-05 ko04730 Long-term depression 12/283 78/7206 4.54441834418e-05 ko04970 Salivary secretion 13/283 95/7206 7.76334859533e-05 ko04726 Serotonergic synapse 16/283 137/7206 8.49233693603e-05 ko04022 cGMP-PKG signaling pathway 21/283 216/7206 0.000106048913277 ko04070 Phosphatidylinositol signaling system 14/283 112/7206 0.000113126729619 ko05213 Endometrial cancer 10/283 62/7206 0.000130851923557 ko04725 Cholinergic synapse 17/283 160/7206 0.000167152669477 ko04360 Axon guidance 21/283 233/7206 0.00038196534072 ko04514 Cell adhesion molecules (CAMs) 14/283 130/7206 0.0005459770221 ko05014 Amyotrophic lateral sclerosis (ALS) 10/283 74/7206 0.000576961030734 ko00512 Mucin type O-glycan biosynthesis 6/283 29/7206 0.00076983139529 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 10/283 79/7206 0.000973464701655 ko05214 Glioma 10/283 79/7206 0.000973464701655 ko04010 MAPK signaling pathway 25/283 321/7206 0.000986424627896 ko04721 Synaptic vesicle cycle 10/283 80/7206 0.0010747854147 ko04742 Taste transduction 8/283 61/7206 0.00246918663164 ko04012 ErbB signaling pathway 11/283 109/7206 0.00353658633273 ko04740 Olfactory transduction 9/283 80/7206 0.00393013997982 ko04924 Renin secretion 9/283 86/7206 0.00635427357232 ko00562 Inositol phosphate metabolism 9/283 89/7206 0.00793240493205 ko04014 Ras signaling pathway 20/283 279/7206 0.0105576866579 ko04972 Pancreatic secretion 10/283 111/7206 0.0116098505448 ko05414 Dilated cardiomyopathy 10/283 112/7206 0.0123205571656 ko04072 Phospholipase D signaling pathway 15/283 197/7206 0.0136009991323 ko04260 Cardiac muscle contraction 9/283 98/7206 0.0144800050137 ko04971 Gastric acid secretion 9/283 98/7206 0.0144800050137 ko00515 Mannose type O-glycan biosynthesis 4/283 25/7206 0.0153529246014 ko05034 Alcoholism 17/283 238/7206 0.0159793188919 ko04015 Rap1 signaling pathway 19/283 278/7206 0.017035405393 ko04930 Type II diabetes mellitus 6/283 54/7206 0.0184731458907 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/283 28/7206 0.0226735957709 ko03013 RNA transport 1/283 166/7206 0.0229026537423 ko00513 Various types of N-glycan biosynthesis 5/283 42/7206 0.0233740070426 ko04973 Carbohydrate digestion and absorption 5/283 42/7206 0.0233740070426 ko04962 Vasopressin-regulated water reabsorption 6/283 58/7206 0.0254399392238 ko04916 Melanogenesis 11/283 142/7206 0.0268246486552 ko04912 GnRH signaling pathway 10/283 122/7206 0.0285740781638 ko04923 Regulation of lipolysis in adipocytes 7/283 77/7206 0.0309094660678 ko04142 Lysosome 1/283 151/7206 0.0315837016521 ko04722 Neurotrophin signaling pathway 12/283 160/7206 0.0350331185998 ko01521 EGFR tyrosine kinase inhibitor resistance 9/283 106/7206 0.0369327781955 ko05231 Choline metabolism in cancer 10/283 134/7206 0.0420531190754 ko05223 Non-small cell lung cancer 6/283 66/7206 0.0441617462704 ko00510 N-Glycan biosynthesis 5/283 50/7206 0.0452906999315 ko04910 Insulin signaling pathway 12/283 172/7206 0.045528117158 ko03040 Spliceosome 1/283 145/7206 0.0469952840017