ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 28/265 152/7206 8.26284024637e-13 ko05033 Nicotine addiction 17/265 56/7206 6.68143863536e-12 ko04728 Dopaminergic synapse 27/265 185/7206 5.7678960917e-10 ko04727 GABAergic synapse 20/265 110/7206 2.2541117702e-09 ko04721 Synaptic vesicle cycle 17/265 80/7206 3.12270814252e-09 ko04723 Retrograde endocannabinoid signaling 23/265 175/7206 8.69477275051e-08 ko04911 Insulin secretion 18/265 117/7206 2.1393519109e-07 ko05032 Morphine addiction 17/265 110/7206 4.39331844911e-07 ko04713 Circadian entrainment 19/265 136/7206 4.62374767395e-07 ko04080 Neuroactive ligand-receptor interaction 36/265 423/7206 1.70376698738e-06 ko04514 Cell adhesion molecules (CAMs) 17/265 130/7206 4.78016622263e-06 ko04261 Adrenergic signaling in cardiomyocytes 22/265 205/7206 5.4903054991e-06 ko04024 cAMP signaling pathway 25/265 279/7206 3.02858576441e-05 ko05030 Cocaine addiction 11/265 73/7206 6.34080558418e-05 ko05031 Amphetamine addiction 12/265 91/7206 0.000112711171731 ko04726 Serotonergic synapse 15/265 137/7206 0.000141428782233 ko04010 MAPK signaling pathway 25/265 321/7206 0.000352763373364 ko04022 cGMP-PKG signaling pathway 19/265 216/7206 0.000353939140012 ko05203 Viral carcinogenesis 1/265 277/7206 0.000505415591887 ko00512 Mucin type O-glycan biosynthesis 6/265 29/7206 0.000543673570564 ko04970 Salivary secretion 11/265 95/7206 0.000680302820627 ko04725 Cholinergic synapse 15/265 160/7206 0.000765324635728 ko04020 Calcium signaling pathway 21/265 265/7206 0.00117635957937 ko04666 Fc gamma R-mediated phagocytosis 12/265 122/7206 0.00168732302123 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/265 79/7206 0.00232084440701 ko04915 Estrogen signaling pathway 12/265 131/7206 0.00307882969339 ko04260 Cardiac muscle contraction 10/265 98/7206 0.00308580513666 ko04973 Carbohydrate digestion and absorption 6/265 42/7206 0.00402508749942 ko04742 Taste transduction 7/265 61/7206 0.00671497059505 ko04730 Long-term depression 8/265 78/7206 0.00760766954008 ko04720 Long-term potentiation 9/265 99/7206 0.0103412704524 ko04921 Oxytocin signaling pathway 15/265 209/7206 0.0131991003413 ko04924 Renin secretion 8/265 86/7206 0.0134001671499 ko04930 Type II diabetes mellitus 6/265 54/7206 0.0137468098153 ko00513 Various types of N-glycan biosynthesis 5/265 42/7206 0.0181248182122 ko04072 Phospholipase D signaling pathway 14/265 197/7206 0.0184997774698 ko05014 Amyotrophic lateral sclerosis (ALS) 7/265 74/7206 0.0185362451371 ko04360 Axon guidance 16/265 233/7206 0.0190593206103 ko04962 Vasopressin-regulated water reabsorption 6/265 58/7206 0.0190855292711 ko04972 Pancreatic secretion 9/265 111/7206 0.0206739269231 ko04014 Ras signaling pathway 18/265 279/7206 0.0211342831145 ko05213 Endometrial cancer 6/265 62/7206 0.0256904976081 ko05410 Hypertrophic cardiomyopathy (HCM) 8/265 100/7206 0.0303922420036 ko04621 NOD-like receptor signaling pathway 1/265 157/7206 0.0313527958913 ko05231 Choline metabolism in cancer 10/265 134/7206 0.0317859694189 ko04144 Endocytosis 20/265 342/7206 0.0378244506765 ko04371 Apelin signaling pathway 12/265 177/7206 0.0392992388559