ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1199	423/7206	8.58176662384e-54
ko04724	Glutamatergic synapse	91/1199	152/7206	4.79865143707e-34
ko05033	Nicotine addiction	48/1199	56/7206	6.6810264683e-30
ko05032	Morphine addiction	69/1199	110/7206	8.88011426163e-28
ko04727	GABAergic synapse	67/1199	110/7206	6.4782714597e-26
ko04713	Circadian entrainment	75/1199	136/7206	4.95226817884e-25
ko04721	Synaptic vesicle cycle	52/1199	80/7206	2.96463926025e-22
ko04728	Dopaminergic synapse	85/1199	185/7206	3.50123582958e-21
ko04725	Cholinergic synapse	76/1199	160/7206	4.05868349774e-20
ko04020	Calcium signaling pathway	105/1199	265/7206	9.60100806936e-20
ko04024	cAMP signaling pathway	108/1199	279/7206	2.19933617996e-19
ko04723	Retrograde endocannabinoid signaling	78/1199	175/7206	1.52712119387e-18
ko04742	Taste transduction	38/1199	61/7206	1.11334156987e-15
ko04911	Insulin secretion	55/1199	117/7206	1.22905358294e-14
ko04921	Oxytocin signaling pathway	79/1199	209/7206	8.9092438639e-14
ko04726	Serotonergic synapse	59/1199	137/7206	1.6825643495e-13
ko04744	Phototransduction	26/1199	36/7206	2.05380579216e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1199	205/7206	2.67040752897e-12
ko05031	Amphetamine addiction	42/1199	91/7206	3.69694417198e-11
ko04970	Salivary secretion	43/1199	95/7206	4.78091422984e-11
ko04720	Long-term potentiation	44/1199	99/7206	6.0155170361e-11
ko03040	Spliceosome	1/1199	145/7206	1.18531342373e-10
ko04360	Axon guidance	77/1199	233/7206	4.81245134499e-10
ko05203	Viral carcinogenesis	16/1199	277/7206	5.77789734339e-08
ko04925	Aldosterone synthesis and secretion	40/1199	105/7206	9.65898349421e-08
ko04022	cGMP-PKG signaling pathway	67/1199	216/7206	1.22893565421e-07
ko04971	Gastric acid secretion	37/1199	98/7206	3.80209397587e-07
ko05030	Cocaine addiction	30/1199	73/7206	5.62327020673e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1199	74/7206	7.97413215429e-07
ko03013	RNA transport	7/1199	166/7206	1.29933506917e-06
ko05322	Systemic lupus erythematosus	6/1199	151/7206	2.22296159201e-06
ko04070	Phosphatidylinositol signaling system	39/1199	112/7206	2.28610755542e-06
ko04966	Collecting duct acid secretion	15/1199	26/7206	2.37013802544e-06
ko05168	Herpes simplex infection	9/1199	182/7206	2.39099663069e-06
ko04060	Cytokine-cytokine receptor interaction	10/1199	191/7206	2.57049064136e-06
ko04740	Olfactory transduction	30/1199	80/7206	5.85819081111e-06
ko04010	MAPK signaling pathway	84/1199	321/7206	1.05339033867e-05
ko04514	Cell adhesion molecules (CAMs)	42/1199	130/7206	1.23629007855e-05
ko04924	Renin secretion	31/1199	86/7206	1.2440176469e-05
ko04610	Complement and coagulation cascades	1/1199	79/7206	1.29021406549e-05
ko05164	Influenza A	9/1199	167/7206	1.30865698923e-05
ko04972	Pancreatic secretion	37/1199	111/7206	1.43451146867e-05
ko04540	Gap junction	41/1199	128/7206	1.8615213636e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1199	79/7206	4.61972535202e-05
ko04621	NOD-like receptor signaling pathway	9/1199	157/7206	5.06661420154e-05
ko05414	Dilated cardiomyopathy	36/1199	112/7206	5.12939409762e-05
ko04141	Protein processing in endoplasmic reticulum	12/1199	184/7206	5.22510420433e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1199	79/7206	0.000112065507923
ko05110	Vibrio cholerae infection	23/1199	63/7206	0.000118007836211
ko04745	Phototransduction - fly	16/1199	38/7206	0.000178701070499
ko04750	Inflammatory mediator regulation of TRP channels	37/1199	122/7206	0.000183049250857
ko04120	Ubiquitin mediated proteolysis	8/1199	138/7206	0.000186997851838
ko05205	Proteoglycans in cancer	24/1199	271/7206	0.000234482466199
ko05140	Leishmaniasis	2/1199	75/7206	0.000248708176182
ko04064	NF-kappa B signaling pathway	4/1199	96/7206	0.000271410405881
ko05169	Epstein-Barr virus infection	16/1199	206/7206	0.000273986005795
ko04014	Ras signaling pathway	70/1199	279/7206	0.000282002870613
ko04260	Cardiac muscle contraction	31/1199	98/7206	0.000291209182136
ko04915	Estrogen signaling pathway	38/1199	131/7206	0.000333114376908
ko04976	Bile secretion	26/1199	80/7206	0.000414237669775
ko04072	Phospholipase D signaling pathway	52/1199	197/7206	0.000434550698819
ko04923	Regulation of lipolysis in adipocytes	25/1199	77/7206	0.000563113961428
ko05161	Hepatitis B	13/1199	173/7206	0.000585189107892
ko04730	Long-term depression	25/1199	78/7206	0.000660087837694
ko04110	Cell cycle	10/1199	145/7206	0.000669734940145
ko04612	Antigen processing and presentation	3/1199	77/7206	0.00101882109579
ko04626	Plant-pathogen interaction	9/1199	18/7206	0.00109915465819
ko04371	Apelin signaling pathway	46/1199	177/7206	0.00141707982692
ko05162	Measles	8/1199	120/7206	0.00181350038058
ko00240	Pyrimidine metabolism	7/1199	110/7206	0.00183852749938
ko00562	Inositol phosphate metabolism	26/1199	89/7206	0.00250063491167
ko00330	Arginine and proline metabolism	2/1199	61/7206	0.00270367287718
ko04146	Peroxisome	5/1199	89/7206	0.00366161787066
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1199	14/7206	0.00403109691774
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1199	59/7206	0.00408798788678
ko05144	Malaria	1/1199	45/7206	0.00434857450098
ko00071	Fatty acid degradation	1/1199	45/7206	0.00434857450098
ko03420	Nucleotide excision repair	1/1199	46/7206	0.0044317761631
ko04964	Proximal tubule bicarbonate reclamation	11/1199	29/7206	0.00486564304044
ko00480	Glutathione metabolism	2/1199	55/7206	0.00563380371801
ko04640	Hematopoietic cell lineage	3/1199	64/7206	0.0063751680917
ko00310	Lysine degradation	4/1199	73/7206	0.00674575233256
ko03022	Basal transcription factors	1/1199	44/7206	0.00681195647888
ko05131	Shigellosis	5/1199	82/7206	0.00684105354973
ko05145	Toxoplasmosis	10/1199	126/7206	0.00741201831396
ko00590	Arachidonic acid metabolism	2/1199	52/7206	0.00819661152878
ko04630	Jak-STAT signaling pathway	11/1199	132/7206	0.00893097953273
ko04622	RIG-I-like receptor signaling pathway	3/1199	62/7206	0.00921356080166
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1199	100/7206	0.00942256713607
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1199	40/7206	0.00980977484374
ko04270	Vascular smooth muscle contraction	38/1199	154/7206	0.011348797255
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1199	182/7206	0.0115025126149
ko00380	Tryptophan metabolism	2/1199	50/7206	0.0120283422821
ko05133	Pertussis	6/1199	87/7206	0.0128781834798
ko00630	Glyoxylate and dicarboxylate metabolism	1/1199	38/7206	0.0147556031034
ko00982	Drug metabolism - cytochrome P450	1/1199	37/7206	0.0147647289585
ko03018	RNA degradation	6/1199	84/7206	0.0174043620012
ko00260	Glycine, serine and threonine metabolism	2/1199	48/7206	0.0177341388047
ko05219	Bladder cancer	2/1199	48/7206	0.0177341388047
ko04115	p53 signaling pathway	5/1199	74/7206	0.0181058669948
ko05206	MicroRNAs in cancer	18/1199	177/7206	0.0183765096946
ko05321	Inflammatory bowel disease (IBD)	3/1199	56/7206	0.0184886199342
ko04918	Thyroid hormone synthesis	23/1199	86/7206	0.0185457279738
ko04510	Focal adhesion	27/1199	240/7206	0.0216927793742
ko04916	Melanogenesis	34/1199	142/7206	0.0225250991382
ko04214	Apoptosis - fly	5/1199	72/7206	0.0249393390441
ko04912	GnRH signaling pathway	30/1199	122/7206	0.0263179380937
ko00280	Valine, leucine and isoleucine degradation	3/1199	54/7206	0.0263188534217
ko04658	Th1 and Th2 cell differentiation	8/1199	96/7206	0.0265970018236
ko04015	Rap1 signaling pathway	60/1199	278/7206	0.0266063738557
ko04114	Oocyte meiosis	33/1199	139/7206	0.0284400602734
ko05215	Prostate cancer	10/1199	111/7206	0.0284758324341
ko04657	IL-17 signaling pathway	7/1199	87/7206	0.0291051934171
ko03320	PPAR signaling pathway	5/1199	69/7206	0.0339496518474
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1199	92/7206	0.0347105698515
ko04930	Type II diabetes mellitus	15/1199	54/7206	0.0409832028359
ko04620	Toll-like receptor signaling pathway	9/1199	100/7206	0.0415199095356
ko04922	Glucagon signaling pathway	30/1199	128/7206	0.0417310117216
ko04210	Apoptosis	20/1199	180/7206	0.042685506577
ko01524	Platinum drug resistance	6/1199	76/7206	0.0427298142198
ko05166	HTLV-I infection	36/1199	292/7206	0.0447202927538
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1199	135/7206	0.0474207911682
ko05340	Primary immunodeficiency	1/1199	30/7206	0.0487671910784