ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1147	423/7206	5.60245337275e-58
ko05033	Nicotine addiction	49/1147	56/7206	2.40355233959e-32
ko04724	Glutamatergic synapse	86/1147	152/7206	3.74855427774e-31
ko04713	Circadian entrainment	77/1147	136/7206	5.29670927501e-28
ko05032	Morphine addiction	65/1147	110/7206	3.06088719139e-25
ko04727	GABAergic synapse	64/1147	110/7206	2.41485245106e-24
ko04721	Synaptic vesicle cycle	48/1147	80/7206	2.50064824228e-19
ko04728	Dopaminergic synapse	80/1147	185/7206	3.16208687335e-19
ko04725	Cholinergic synapse	72/1147	160/7206	1.38163213652e-18
ko04020	Calcium signaling pathway	100/1147	265/7206	1.53397070887e-18
ko04024	cAMP signaling pathway	103/1147	279/7206	2.95680706996e-18
ko04723	Retrograde endocannabinoid signaling	75/1147	175/7206	8.08326758985e-18
ko04911	Insulin secretion	55/1147	117/7206	1.7079155499e-15
ko04742	Taste transduction	36/1147	61/7206	1.71566789347e-14
ko04726	Serotonergic synapse	59/1147	137/7206	2.22395209505e-14
ko04744	Phototransduction	26/1147	36/7206	6.9536660201e-14
ko04921	Oxytocin signaling pathway	76/1147	209/7206	3.02881939564e-13
ko04740	Olfactory transduction	38/1147	80/7206	2.83282971442e-11
ko05031	Amphetamine addiction	41/1147	91/7206	3.86362838246e-11
ko04970	Salivary secretion	42/1147	95/7206	4.72970265598e-11
ko04720	Long-term potentiation	43/1147	99/7206	5.64827323833e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1147	205/7206	8.18038429773e-11
ko05203	Viral carcinogenesis	12/1147	277/7206	1.40294760824e-09
ko03040	Spliceosome	2/1147	145/7206	6.43952056708e-09
ko04925	Aldosterone synthesis and secretion	40/1147	105/7206	3.68442322883e-08
ko05168	Herpes simplex infection	6/1147	182/7206	8.49605501102e-08
ko04971	Gastric acid secretion	37/1147	98/7206	1.5104397647e-07
ko05322	Systemic lupus erythematosus	4/1147	151/7206	2.10168731378e-07
ko04022	cGMP-PKG signaling pathway	64/1147	216/7206	2.36030297819e-07
ko05030	Cocaine addiction	29/1147	73/7206	7.78924892036e-07
ko04060	Cytokine-cytokine receptor interaction	9/1147	191/7206	1.7638991294e-06
ko03013	RNA transport	7/1147	166/7206	2.82199477134e-06
ko04745	Phototransduction - fly	18/1147	38/7206	5.21425344592e-06
ko04120	Ubiquitin mediated proteolysis	5/1147	138/7206	8.99368651237e-06
ko05169	Epstein-Barr virus infection	12/1147	206/7206	1.11911698308e-05
ko04621	NOD-like receptor signaling pathway	7/1147	157/7206	1.20639767245e-05
ko04730	Long-term depression	28/1147	78/7206	1.34610016537e-05
ko05164	Influenza A	8/1147	167/7206	1.35042841868e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1147	74/7206	1.48429408593e-05
ko04924	Renin secretion	30/1147	86/7206	1.69522960061e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1147	79/7206	1.71451419901e-05
ko04972	Pancreatic secretion	36/1147	111/7206	1.75532760165e-05
ko04260	Cardiac muscle contraction	32/1147	98/7206	3.53003150078e-05
ko04010	MAPK signaling pathway	79/1147	321/7206	4.33533100005e-05
ko04514	Cell adhesion molecules (CAMs)	39/1147	130/7206	4.8062411599e-05
ko04110	Cell cycle	7/1147	145/7206	4.80877183559e-05
ko04360	Axon guidance	61/1147	233/7206	5.19560086353e-05
ko04966	Collecting duct acid secretion	13/1147	26/7206	5.34003835249e-05
ko04540	Gap junction	38/1147	128/7206	7.40278922599e-05
ko04976	Bile secretion	27/1147	80/7206	7.5584166942e-05
ko05110	Vibrio cholerae infection	22/1147	63/7206	0.000181933242934
ko05166	HTLV-I infection	25/1147	292/7206	0.000222813291651
ko03008	Ribosome biogenesis in eukaryotes	2/1147	79/7206	0.000268465725706
ko04070	Phosphatidylinositol signaling system	33/1147	112/7206	0.000346904384315
ko05205	Proteoglycans in cancer	23/1147	271/7206	0.000351918038325
ko05162	Measles	6/1147	120/7206	0.000356053929065
ko05140	Leishmaniasis	2/1147	75/7206	0.00038821844141
ko04612	Antigen processing and presentation	2/1147	77/7206	0.000410145148588
ko04141	Protein processing in endoplasmic reticulum	13/1147	184/7206	0.000460705283811
ko05161	Hepatitis B	12/1147	173/7206	0.000479128635641
ko04064	NF-kappa B signaling pathway	4/1147	96/7206	0.000604585356576
ko05414	Dilated cardiomyopathy	32/1147	112/7206	0.000607783513242
ko04750	Inflammatory mediator regulation of TRP channels	34/1147	122/7206	0.000665756796785
ko04626	Plant-pathogen interaction	9/1147	18/7206	0.000787778239256
ko04214	Apoptosis - fly	2/1147	72/7206	0.000906639215244
ko00480	Glutathione metabolism	1/1147	55/7206	0.00132850976343
ko04610	Complement and coagulation cascades	3/1147	79/7206	0.00160972130884
ko04371	Apelin signaling pathway	44/1147	177/7206	0.0017194704127
ko04014	Ras signaling pathway	64/1147	279/7206	0.00191229150336
ko04072	Phospholipase D signaling pathway	48/1147	197/7206	0.00204617555504
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1147	100/7206	0.00212688518841
ko04330	Notch signaling pathway	2/1147	62/7206	0.00270576103656
ko04915	Estrogen signaling pathway	34/1147	131/7206	0.00347211228138
ko04930	Type II diabetes mellitus	17/1147	54/7206	0.00414724759076
ko04630	Jak-STAT signaling pathway	10/1147	132/7206	0.00561657391711
ko03022	Basal transcription factors	1/1147	44/7206	0.0067766423875
ko05144	Malaria	1/1147	45/7206	0.00679794960414
ko01524	Platinum drug resistance	4/1147	76/7206	0.00696422489601
ko04658	Th1 and Th2 cell differentiation	6/1147	96/7206	0.00703071457893
ko03420	Nucleotide excision repair	1/1147	46/7206	0.00705517142502
ko04657	IL-17 signaling pathway	5/1147	87/7206	0.00721433966115
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1147	182/7206	0.00726137208314
ko05215	Prostate cancer	8/1147	111/7206	0.0086097251865
ko05321	Inflammatory bowel disease (IBD)	2/1147	56/7206	0.00883673295104
ko03018	RNA degradation	5/1147	84/7206	0.00992251770509
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1147	59/7206	0.0112277869094
ko04912	GnRH signaling pathway	30/1147	122/7206	0.0120394072576
ko00590	Arachidonic acid metabolism	2/1147	52/7206	0.0123366345647
ko04142	Lysosome	13/1147	151/7206	0.0128121902485
ko04622	RIG-I-like receptor signaling pathway	3/1147	62/7206	0.0134918114888
ko05418	Fluid shear stress and atherosclerosis	16/1147	173/7206	0.0150276764171
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1147	14/7206	0.0152462100841
ko04964	Proximal tubule bicarbonate reclamation	10/1147	29/7206	0.0175726741531
ko05016	Huntington's disease	22/1147	215/7206	0.0180114464439
ko04350	TGF-beta signaling pathway	8/1147	103/7206	0.0205311062835
ko04668	TNF signaling pathway	10/1147	120/7206	0.0226151224048
ko05220	Chronic myeloid leukemia	6/1147	85/7206	0.0241512050606
ko00240	Pyrimidine metabolism	9/1147	110/7206	0.0247865875171
ko04270	Vascular smooth muscle contraction	35/1147	154/7206	0.0253484296187
ko04115	p53 signaling pathway	5/1147	74/7206	0.0254764608151
ko05145	Toxoplasmosis	11/1147	126/7206	0.0262482712238
ko04923	Regulation of lipolysis in adipocytes	20/1147	77/7206	0.0265943559455
ko04978	Mineral absorption	12/1147	40/7206	0.0266485844396
ko05219	Bladder cancer	2/1147	48/7206	0.026769925998
ko04620	Toll-like receptor signaling pathway	8/1147	100/7206	0.027164387221
ko04922	Glucagon signaling pathway	30/1147	128/7206	0.0272276294468
ko00562	Inositol phosphate metabolism	22/1147	89/7206	0.0281956530404
ko04217	Necroptosis	18/1147	178/7206	0.0294404171156
ko04210	Apoptosis	18/1147	180/7206	0.02962217261
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1147	165/7206	0.0305207791453
ko05131	Shigellosis	6/1147	82/7206	0.0324287166221
ko05212	Pancreatic cancer	6/1147	83/7206	0.032998117481
ko00860	Porphyrin and chlorophyll metabolism	1/1147	34/7206	0.0335036899557
ko00310	Lysine degradation	5/1147	73/7206	0.0350260682443
ko04640	Hematopoietic cell lineage	4/1147	64/7206	0.0373621723322
ko00071	Fatty acid degradation	2/1147	45/7206	0.0380394468203
ko00280	Valine, leucine and isoleucine degradation	3/1147	54/7206	0.0380578195199
ko04146	Peroxisome	7/1147	89/7206	0.0398683301228
ko05200	Pathways in cancer	62/1147	492/7206	0.0408066036969
ko04113	Meiosis - yeast	5/1147	70/7206	0.0472986851091