ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 12/330 30/7206 2.86830833763e-09 ko04380 Osteoclast differentiation 23/330 134/7206 3.10842873836e-08 ko05164 Influenza A 24/330 167/7206 5.00229114186e-07 ko04650 Natural killer cell mediated cytotoxicity 17/330 97/7206 1.51253152762e-06 ko04060 Cytokine-cytokine receptor interaction 25/330 191/7206 1.71775798436e-06 ko04660 T cell receptor signaling pathway 19/330 124/7206 3.02255324305e-06 ko05140 Leishmaniasis 14/330 75/7206 5.99436245931e-06 ko04064 NF-kappa B signaling pathway 16/330 96/7206 6.09476742256e-06 ko04621 NOD-like receptor signaling pathway 21/330 157/7206 8.41212044318e-06 ko05145 Toxoplasmosis 18/330 126/7206 1.50351439685e-05 ko05162 Measles 17/330 120/7206 2.90296353919e-05 ko05152 Tuberculosis 22/330 187/7206 4.01745808201e-05 ko04658 Th1 and Th2 cell differentiation 14/330 96/7206 0.000106887005578 ko05133 Pertussis 13/330 87/7206 0.000146104177412 ko04662 B cell receptor signaling pathway 13/330 88/7206 0.000164487122303 ko04612 Antigen processing and presentation 12/330 77/7206 0.000174297605245 ko05150 Staphylococcus aureus infection 8/330 36/7206 0.000174370322686 ko00120 Primary bile acid biosynthesis 6/330 20/7206 0.000197865501495 ko04672 Intestinal immune network for IgA production 8/330 37/7206 0.000213736772616 ko04610 Complement and coagulation cascades 12/330 79/7206 0.000223689141506 ko05320 Autoimmune thyroid disease 7/330 29/7206 0.0002583212668 ko04659 Th17 cell differentiation 14/330 106/7206 0.000311939922795 ko05034 Alcoholism 1/330 238/7206 0.00036422110355 ko04666 Fc gamma R-mediated phagocytosis 15/330 122/7206 0.000423377428613 ko05330 Allograft rejection 6/330 24/7206 0.000588184081387 ko04620 Toll-like receptor signaling pathway 13/330 100/7206 0.000593615384727 ko05144 Malaria 8/330 45/7206 0.000866794494913 ko05321 Inflammatory bowel disease (IBD) 9/330 56/7206 0.000894696282364 ko05332 Graft-versus-host disease 5/330 18/7206 0.00102161880164 ko04611 Platelet activation 17/330 163/7206 0.00165846326743 ko04360 Axon guidance 2/330 233/7206 0.00214333399869 ko00590 Arachidonic acid metabolism 8/330 52/7206 0.00229044387945 ko04623 Cytosolic DNA-sensing pathway 7/330 41/7206 0.0023196515256 ko05323 Rheumatoid arthritis 11/330 89/7206 0.00233573349944 ko05161 Hepatitis B 17/330 173/7206 0.0026026511747 ko03050 Proteasome 8/330 54/7206 0.00292515328432 ko04512 ECM-receptor interaction 10/330 79/7206 0.00305604825921 ko04217 Necroptosis 17/330 178/7206 0.00523509437739 ko04210 Apoptosis 17/330 180/7206 0.00545035091306 ko05168 Herpes simplex infection 17/330 182/7206 0.00571811579657 ko04622 RIG-I-like receptor signaling pathway 8/330 62/7206 0.00692676311264 ko04664 Fc epsilon RI signaling pathway 9/330 77/7206 0.00821819861521 ko04640 Hematopoietic cell lineage 8/330 64/7206 0.00838011742895 ko05142 Chagas disease (American trypanosomiasis) 13/330 130/7206 0.00850446076202 ko05020 Prion diseases 6/330 40/7206 0.00905779718637 ko04630 Jak-STAT signaling pathway 13/330 132/7206 0.00916914295645 ko00592 alpha-Linolenic acid metabolism 4/330 19/7206 0.0096918614568 ko00565 Ether lipid metabolism 6/330 42/7206 0.011468961992 ko04068 FoxO signaling pathway 15/330 167/7206 0.0127318342926 ko04940 Type I diabetes mellitus 5/330 32/7206 0.0142032839967 ko04062 Chemokine signaling pathway 17/330 201/7206 0.0147408310946 ko03040 Spliceosome 1/330 145/7206 0.0148777366867 ko00350 Tyrosine metabolism 5/330 33/7206 0.0161291474295 ko04514 Cell adhesion molecules (CAMs) 12/330 130/7206 0.0178209418684 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/330 5/7206 0.0190711827899 ko00281 Geraniol degradation 2/330 5/7206 0.0190711827899 ko04145 Phagosome 14/330 162/7206 0.0203848273819 ko05166 HTLV-I infection 22/330 292/7206 0.0209320403384 ko04713 Circadian entrainment 1/330 136/7206 0.0214822349744 ko04726 Serotonergic synapse 1/330 137/7206 0.0215458470626 ko04080 Neuroactive ligand-receptor interaction 10/330 423/7206 0.0221520054098 ko04668 TNF signaling pathway 11/330 120/7206 0.0246484648934 ko04540 Gap junction 1/330 128/7206 0.0310338999472 ko03010 Ribosome 1/330 129/7206 0.0311750687816 ko04020 Calcium signaling pathway 5/330 265/7206 0.0341838422541 ko03013 RNA transport 2/330 166/7206 0.0357494276082 ko00140 Steroid hormone biosynthesis 5/330 41/7206 0.0379040702607 ko05310 Asthma 3/330 17/7206 0.0401599842684 ko00360 Phenylalanine metabolism 3/330 17/7206 0.0401599842684 ko00051 Fructose and mannose metabolism 5/330 42/7206 0.0414763821886 ko04911 Insulin secretion 1/330 117/7206 0.0444965724537 ko00966 Glucosinolate biosynthesis 1/330 1/7206 0.0457951706911 ko04724 Glutamatergic synapse 2/330 152/7206 0.0485786847567 ko04390 Hippo signaling pathway 3/330 188/7206 0.0493928359712