ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 35/358 79/7206 2.04931486396e-25 ko04974 Protein digestion and absorption 25/358 96/7206 3.28782941473e-12 ko04975 Fat digestion and absorption 15/358 35/7206 2.71961028399e-11 ko00260 Glycine, serine and threonine metabolism 17/358 48/7206 4.86181006341e-11 ko00980 Metabolism of xenobiotics by cytochrome P450 13/358 40/7206 3.20947718523e-08 ko04950 Maturity onset diabetes of the young 11/358 29/7206 6.02868387004e-08 ko04978 Mineral absorption 12/358 40/7206 2.9751405569e-07 ko05204 Chemical carcinogenesis 13/358 48/7206 3.57941708474e-07 ko04977 Vitamin digestion and absorption 9/358 22/7206 4.66840108997e-07 ko05150 Staphylococcus aureus infection 10/358 36/7206 6.43897305484e-06 ko04976 Bile secretion 15/358 80/7206 7.14059884365e-06 ko00982 Drug metabolism - cytochrome P450 10/358 37/7206 8.43879684166e-06 ko00480 Glutathione metabolism 12/358 55/7206 1.18746500481e-05 ko04614 Renin-angiotensin system 7/358 18/7206 1.39338058814e-05 ko00983 Drug metabolism - other enzymes 10/358 42/7206 2.85275123374e-05 ko04512 ECM-receptor interaction 13/358 79/7206 0.000120575499097 ko03320 PPAR signaling pathway 12/358 69/7206 0.000127140145457 ko00330 Arginine and proline metabolism 11/358 61/7206 0.000173449184996 ko01200 Carbon metabolism 17/358 128/7206 0.000182333043672 ko04144 Endocytosis 4/358 342/7206 0.000184303122274 ko04146 Peroxisome 13/358 89/7206 0.000409555998491 ko00630 Glyoxylate and dicarboxylate metabolism 8/358 38/7206 0.000451643782086 ko05169 Epstein-Barr virus infection 1/358 206/7206 0.000496389245054 ko05034 Alcoholism 2/358 238/7206 0.000716631900143 ko04062 Chemokine signaling pathway 1/358 201/7206 0.000745207563184 ko04360 Axon guidance 2/358 233/7206 0.00104566164997 ko04080 Neuroactive ligand-receptor interaction 8/358 423/7206 0.00116155200446 ko00040 Pentose and glucuronate interconversions 6/358 26/7206 0.00142269213437 ko00270 Cysteine and methionine metabolism 8/358 47/7206 0.00196535727508 ko04723 Retrograde endocannabinoid signaling 1/358 175/7206 0.00228740206435 ko00591 Linoleic acid metabolism 5/358 22/7206 0.00384460086183 ko00053 Ascorbate and aldarate metabolism 5/358 22/7206 0.00384460086183 ko04973 Carbohydrate digestion and absorption 7/358 42/7206 0.00421475066929 ko00830 Retinol metabolism 7/358 42/7206 0.00421475066929 ko04725 Cholinergic synapse 1/358 160/7206 0.00489230436333 ko04216 Ferroptosis 7/358 44/7206 0.00549887024425 ko05166 HTLV-I infection 5/358 292/7206 0.00551411446188 ko04060 Cytokine-cytokine receptor interaction 2/358 191/7206 0.00619756099717 ko00340 Histidine metabolism 5/358 25/7206 0.00686320463134 ko04260 Cardiac muscle contraction 11/358 98/7206 0.00901764498781 ko05203 Viral carcinogenesis 5/358 277/7206 0.0103129867341 ko00250 Alanine, aspartate and glutamate metabolism 6/358 38/7206 0.0103293414322 ko04110 Cell cycle 1/358 145/7206 0.0104237221966 ko04024 cAMP signaling pathway 5/358 279/7206 0.0104714552451 ko05133 Pertussis 10/358 87/7206 0.0106591429482 ko02010 ABC transporters 6/358 39/7206 0.0117109629877 ko05161 Hepatitis B 2/358 173/7206 0.0123958349305 ko04920 Adipocytokine signaling pathway 10/358 89/7206 0.0124166892192 ko04217 Necroptosis 2/358 178/7206 0.0128168240744 ko04964 Proximal tubule bicarbonate reclamation 5/358 29/7206 0.0130412398688 ko00590 Arachidonic acid metabolism 7/358 52/7206 0.013684766752 ko00643 Styrene degradation 2/358 4/7206 0.0138146023745 ko00140 Steroid hormone biosynthesis 6/358 41/7206 0.0148555761123 ko04010 MAPK signaling pathway 7/358 321/7206 0.0170267482553 ko04140 Autophagy - animal 2/358 164/7206 0.0174912082158 ko00100 Steroid biosynthesis 4/358 21/7206 0.0183120537831 ko04072 Phospholipase D signaling pathway 3/358 197/7206 0.0188022742597 ko04660 T cell receptor signaling pathway 1/358 124/7206 0.0213087036424 ko04670 Leukocyte transendothelial migration 14/358 151/7206 0.0214361808767 ko00472 D-Arginine and D-ornithine metabolism 2/358 5/7206 0.0222721359299 ko00232 Caffeine metabolism 2/358 5/7206 0.0222721359299 ko00311 Penicillin and cephalosporin biosynthesis 2/358 5/7206 0.0222721359299 ko04621 NOD-like receptor signaling pathway 2/358 157/7206 0.0246552753613 ko00620 Pyruvate metabolism 6/358 46/7206 0.0251758884624 ko00410 beta-Alanine metabolism 5/358 35/7206 0.0279925857485 ko00020 Citrate cycle (TCA cycle) 5/358 35/7206 0.0279925857485 ko00770 Pantothenate and CoA biosynthesis 3/358 14/7206 0.0294155426772 ko00010 Glycolysis / Gluconeogenesis 8/358 74/7206 0.0296290923901 ko04141 Protein processing in endoplasmic reticulum 3/358 184/7206 0.0365426085611 ko04728 Dopaminergic synapse 3/358 185/7206 0.0369025654392 ko01230 Biosynthesis of amino acids 9/358 85/7206 0.0373592842252 ko04514 Cell adhesion molecules (CAMs) 12/358 130/7206 0.0375771567824 ko04012 ErbB signaling pathway 1/358 109/7206 0.0442336938245 ko04727 GABAergic synapse 1/358 110/7206 0.0443661925105 ko05020 Prion diseases 5/358 40/7206 0.0464626434649 ko04931 Insulin resistance 12/358 137/7206 0.0465122126019 ko04114 Oocyte meiosis 2/358 139/7206 0.0482594236883 ko00720 Carbon fixation pathways in prokaryotes 3/358 17/7206 0.0492557150948