ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/1108	423/7206	2.12823859021e-45
ko05033	Nicotine addiction	48/1108	56/7206	1.57000506511e-31
ko04724	Glutamatergic synapse	83/1108	152/7206	1.0449622827e-29
ko05032	Morphine addiction	67/1108	110/7206	5.27950118391e-28
ko04727	GABAergic synapse	65/1108	110/7206	4.0160756264e-26
ko04713	Circadian entrainment	69/1108	136/7206	2.18707001968e-22
ko04728	Dopaminergic synapse	81/1108	185/7206	7.72153390076e-21
ko04721	Synaptic vesicle cycle	48/1108	80/7206	5.60323606816e-20
ko04723	Retrograde endocannabinoid signaling	76/1108	175/7206	2.34247890783e-19
ko04725	Cholinergic synapse	71/1108	160/7206	8.69183255408e-19
ko04744	Phototransduction	27/1108	36/7206	1.94144668694e-15
ko04024	cAMP signaling pathway	93/1108	279/7206	2.8077251619e-14
ko04742	Taste transduction	35/1108	61/7206	4.47208006322e-14
ko04726	Serotonergic synapse	56/1108	137/7206	3.29030848919e-13
ko04911	Insulin secretion	49/1108	117/7206	3.48970919279e-12
ko04020	Calcium signaling pathway	85/1108	265/7206	3.69812126921e-12
ko04921	Oxytocin signaling pathway	70/1108	209/7206	3.50631140375e-11
ko04261	Adrenergic signaling in cardiomyocytes	69/1108	205/7206	4.12633343718e-11
ko04740	Olfactory transduction	35/1108	80/7206	1.07490347614e-09
ko03040	Spliceosome	1/1108	145/7206	1.39058241335e-09
ko05031	Amphetamine addiction	37/1108	91/7206	4.28926452057e-09
ko05203	Viral carcinogenesis	12/1108	277/7206	4.49325394625e-09
ko04720	Long-term potentiation	38/1108	99/7206	1.7614063627e-08
ko04970	Salivary secretion	35/1108	95/7206	3.27480123467e-07
ko05030	Cocaine addiction	28/1108	73/7206	1.35999586029e-06
ko04925	Aldosterone synthesis and secretion	36/1108	105/7206	1.5236069984e-06
ko04971	Gastric acid secretion	34/1108	98/7206	1.65986505115e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1108	74/7206	1.87187601327e-06
ko05322	Systemic lupus erythematosus	5/1108	151/7206	3.1311119291e-06
ko04060	Cytokine-cytokine receptor interaction	9/1108	191/7206	5.48544723458e-06
ko05164	Influenza A	7/1108	167/7206	6.14751063201e-06
ko03013	RNA transport	7/1108	166/7206	6.15679813127e-06
ko05168	Herpes simplex infection	9/1108	182/7206	1.49869673247e-05
ko04360	Axon guidance	61/1108	233/7206	1.72560241946e-05
ko04514	Cell adhesion molecules (CAMs)	39/1108	130/7206	2.06628844921e-05
ko04022	cGMP-PKG signaling pathway	57/1108	216/7206	2.08810161829e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1108	79/7206	2.71653785428e-05
ko05205	Proteoglycans in cancer	19/1108	271/7206	3.26295736153e-05
ko04010	MAPK signaling pathway	77/1108	321/7206	3.45050097758e-05
ko04610	Complement and coagulation cascades	1/1108	79/7206	5.23144138273e-05
ko04120	Ubiquitin mediated proteolysis	6/1108	138/7206	6.5296304151e-05
ko04621	NOD-like receptor signaling pathway	8/1108	157/7206	7.58273391782e-05
ko04972	Pancreatic secretion	33/1108	111/7206	9.78100154628e-05
ko04966	Collecting duct acid secretion	12/1108	26/7206	0.000194798786063
ko04745	Phototransduction - fly	15/1108	38/7206	0.000270911507328
ko04070	Phosphatidylinositol signaling system	32/1108	112/7206	0.000303435088401
ko04260	Cardiac muscle contraction	29/1108	98/7206	0.000324979984501
ko04110	Cell cycle	8/1108	145/7206	0.000407732997699
ko03008	Ribosome biogenesis in eukaryotes	2/1108	79/7206	0.000413157657426
ko04072	Phospholipase D signaling pathway	49/1108	197/7206	0.000414106163412
ko05140	Leishmaniasis	2/1108	75/7206	0.000595943937292
ko04730	Long-term depression	24/1108	78/7206	0.000677571083713
ko05162	Measles	6/1108	120/7206	0.000757480818267
ko04976	Bile secretion	24/1108	80/7206	0.000839763384654
ko04141	Protein processing in endoplasmic reticulum	13/1108	184/7206	0.000845505097689
ko04064	NF-kappa B signaling pathway	4/1108	96/7206	0.000884832992281
ko05161	Hepatitis B	12/1108	173/7206	0.000897444924882
ko05169	Epstein-Barr virus infection	16/1108	206/7206	0.0011783606618
ko04924	Renin secretion	25/1108	86/7206	0.00127365366914
ko05414	Dilated cardiomyopathy	30/1108	112/7206	0.00207815473713
ko00480	Glutathione metabolism	1/1108	55/7206	0.00209725587101
ko05166	HTLV-I infection	27/1108	292/7206	0.00212445025793
ko04612	Antigen processing and presentation	3/1108	77/7206	0.00228531691718
ko04964	Proximal tubule bicarbonate reclamation	11/1108	29/7206	0.00257992957334
ko04146	Peroxisome	4/1108	89/7206	0.0026463327666
ko04640	Hematopoietic cell lineage	2/1108	64/7206	0.00278760715249
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1108	59/7206	0.00304537150983
ko04915	Estrogen signaling pathway	33/1108	131/7206	0.00309743737216
ko00590	Arachidonic acid metabolism	1/1108	52/7206	0.00311540996201
ko04750	Inflammatory mediator regulation of TRP channels	31/1108	122/7206	0.00338974571525
ko04014	Ras signaling pathway	60/1108	279/7206	0.00513277228391
ko03420	Nucleotide excision repair	1/1108	46/7206	0.00692520565303
ko00240	Pyrimidine metabolism	7/1108	110/7206	0.00708805615849
ko05110	Vibrio cholerae infection	18/1108	63/7206	0.00736043112256
ko05321	Inflammatory bowel disease (IBD)	2/1108	56/7206	0.00865694899383
ko04540	Gap junction	31/1108	128/7206	0.00882469637335
ko04658	Th1 and Th2 cell differentiation	6/1108	96/7206	0.0097789640846
ko03022	Basal transcription factors	1/1108	44/7206	0.0104314957735
ko05144	Malaria	1/1108	45/7206	0.0108339330615
ko00071	Fatty acid degradation	1/1108	45/7206	0.0108339330615
ko04371	Apelin signaling pathway	40/1108	177/7206	0.01086733406
ko00562	Inositol phosphate metabolism	23/1108	89/7206	0.0109263180481
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1108	100/7206	0.0112895003069
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1108	182/7206	0.012036013336
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1108	14/7206	0.0129098555783
ko04626	Plant-pathogen interaction	7/1108	18/7206	0.0133882731385
ko03018	RNA degradation	5/1108	84/7206	0.0139425667443
ko00310	Lysine degradation	4/1108	73/7206	0.0139750812926
ko05145	Toxoplasmosis	10/1108	126/7206	0.0174257048777
ko00330	Arginine and proline metabolism	3/1108	61/7206	0.0193909506646
ko04622	RIG-I-like receptor signaling pathway	3/1108	62/7206	0.0197793274287
ko04214	Apoptosis - fly	4/1108	72/7206	0.0199484733578
ko04630	Jak-STAT signaling pathway	11/1108	132/7206	0.0205103981893
ko00630	Glyoxylate and dicarboxylate metabolism	1/1108	38/7206	0.0229450050834
ko04657	IL-17 signaling pathway	6/1108	87/7206	0.024375263473
ko05133	Pertussis	6/1108	87/7206	0.024375263473
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1108	40/7206	0.0244639395247
ko04722	Neurotrophin signaling pathway	35/1108	160/7206	0.0262124244674
ko00260	Glycine, serine and threonine metabolism	2/1108	48/7206	0.0262501597859
ko05219	Bladder cancer	2/1108	48/7206	0.0262501597859
ko04217	Necroptosis	17/1108	178/7206	0.0270202212244
ko03320	PPAR signaling pathway	4/1108	69/7206	0.0274834025712
ko04140	Autophagy - animal	15/1108	164/7206	0.02772853984
ko04115	p53 signaling pathway	5/1108	74/7206	0.0352117712563
ko00982	Drug metabolism - cytochrome P450	1/1108	37/7206	0.0356780986614
ko04620	Toll-like receptor signaling pathway	8/1108	100/7206	0.0363613202933
ko04930	Type II diabetes mellitus	14/1108	54/7206	0.0373248502176
ko05131	Shigellosis	6/1108	82/7206	0.0440952938062
ko04137	Mitophagy - animal	6/1108	82/7206	0.0440952938062
ko04510	Focal adhesion	26/1108	240/7206	0.0454789497372
ko04210	Apoptosis	18/1108	180/7206	0.0461387816032