ko pathway ratio_in_study ratio_in_pop p_value ko01200 Carbon metabolism 37/491 128/7206 1.15475391426e-14 ko04974 Protein digestion and absorption 29/491 96/7206 2.7639455881e-12 ko00020 Citrate cycle (TCA cycle) 17/491 35/7206 1.61695803246e-11 ko04260 Cardiac muscle contraction 27/491 98/7206 1.68687220893e-10 ko05410 Hypertrophic cardiomyopathy (HCM) 26/491 100/7206 1.47254691266e-09 ko04512 ECM-receptor interaction 22/491 79/7206 6.89225169893e-09 ko00010 Glycolysis / Gluconeogenesis 21/491 74/7206 1.05302005308e-08 ko05414 Dilated cardiomyopathy 25/491 112/7206 8.46243931326e-08 ko00071 Fatty acid degradation 15/491 45/7206 1.31263501499e-07 ko00620 Pyruvate metabolism 15/491 46/7206 1.82748793439e-07 ko00710 Carbon fixation in photosynthetic organisms 11/491 27/7206 6.3020042178e-07 ko05010 Alzheimer's disease 33/491 202/7206 2.39092564472e-06 ko04510 Focal adhesion 36/491 240/7206 5.59407777167e-06 ko00350 Tyrosine metabolism 11/491 33/7206 6.42322678006e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 30/491 182/7206 6.82070884957e-06 ko00500 Starch and sucrose metabolism 11/491 35/7206 1.22188008926e-05 ko00190 Oxidative phosphorylation 23/491 127/7206 1.25554447156e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 17/491 79/7206 1.70373045891e-05 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 4/491 4/7206 2.13103651533e-05 ko00643 Styrene degradation 4/491 4/7206 2.13103651533e-05 ko01230 Biosynthesis of amino acids 17/491 85/7206 4.64413548932e-05 ko03320 PPAR signaling pathway 15/491 69/7206 4.69071842589e-05 ko04261 Adrenergic signaling in cardiomyocytes 30/491 205/7206 5.67849828896e-05 ko05012 Parkinson's disease 25/491 155/7206 5.76164999165e-05 ko00680 Methane metabolism 10/491 34/7206 5.81165015654e-05 ko00360 Phenylalanine metabolism 7/491 17/7206 6.96603232947e-05 ko04022 cGMP-PKG signaling pathway 30/491 216/7206 0.00016082739314 ko00362 Benzoate degradation 4/491 6/7206 0.000286043804026 ko00140 Steroid hormone biosynthesis 10/491 41/7206 0.000322290601509 ko00380 Tryptophan metabolism 11/491 50/7206 0.000429686134519 ko04922 Glucagon signaling pathway 20/491 128/7206 0.00048442416809 ko05203 Viral carcinogenesis 6/491 277/7206 0.000592608416148 ko01212 Fatty acid metabolism 12/491 60/7206 0.00060209921852 ko04020 Calcium signaling pathway 33/491 265/7206 0.000675725818583 ko03040 Spliceosome 1/491 145/7206 0.000679980728238 ko00250 Alanine, aspartate and glutamate metabolism 9/491 38/7206 0.000806290167905 ko04120 Ubiquitin mediated proteolysis 1/491 138/7206 0.000994361168232 ko05416 Viral myocarditis 11/491 55/7206 0.00100965012332 ko00640 Propanoate metabolism 8/491 34/7206 0.00164105529747 ko00120 Primary bile acid biosynthesis 6/491 20/7206 0.00165061913472 ko00330 Arginine and proline metabolism 11/491 61/7206 0.00243528624759 ko04920 Adipocytokine signaling pathway 14/491 89/7206 0.00257890400479 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/491 5/7206 0.00283445287673 ko00281 Geraniol degradation 3/491 5/7206 0.00283445287673 ko04921 Oxytocin signaling pathway 26/491 209/7206 0.0029652598291 ko00950 Isoquinoline alkaloid biosynthesis 4/491 10/7206 0.00321182863776 ko00630 Glyoxylate and dicarboxylate metabolism 8/491 38/7206 0.00347538832772 ko05146 Amoebiasis 15/491 99/7206 0.00356324390919 ko05016 Huntington's disease 26/491 215/7206 0.00363265986439 ko00230 Purine metabolism 24/491 194/7206 0.00366581830162 ko04110 Cell cycle 2/491 145/7206 0.00412311791861 ko00220 Arginine biosynthesis 6/491 24/7206 0.00454024612703 ko03013 RNA transport 3/491 166/7206 0.0047665160647 ko00030 Pentose phosphate pathway 7/491 32/7206 0.00493134914378 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/491 135/7206 0.00519695513291 ko04614 Renin-angiotensin system 5/491 18/7206 0.00586261400864 ko04114 Oocyte meiosis 2/491 139/7206 0.00588185997201 ko04550 Signaling pathways regulating pluripotency of stem cells 3/491 165/7206 0.00693387032703 ko04728 Dopaminergic synapse 4/491 185/7206 0.00715365205362 ko04146 Peroxisome 13/491 89/7206 0.00869389709672 ko01210 2-Oxocarboxylic acid metabolism 5/491 20/7206 0.00947499357436 ko00280 Valine, leucine and isoleucine degradation 9/491 54/7206 0.00997057109333 ko04672 Intestinal immune network for IgA production 7/491 37/7206 0.0112365545733 ko04142 Lysosome 3/491 151/7206 0.0131619436678 ko04724 Glutamatergic synapse 3/491 152/7206 0.0133095203967 ko04720 Long-term potentiation 1/491 99/7206 0.0142190366271 ko04014 Ras signaling pathway 9/491 279/7206 0.0145456442531 ko00260 Glycine, serine and threonine metabolism 8/491 48/7206 0.0147641064001 ko00051 Fructose and mannose metabolism 7/491 42/7206 0.0219767897226 ko00830 Retinol metabolism 7/491 42/7206 0.0219767897226 ko00052 Galactose metabolism 6/491 33/7206 0.0222311615009 ko04380 Osteoclast differentiation 16/491 134/7206 0.0237785412477 ko04710 Circadian rhythm 7/491 43/7206 0.0247644485779 ko00720 Carbon fixation pathways in prokaryotes 4/491 17/7206 0.0248764593559 ko04726 Serotonergic synapse 3/491 137/7206 0.0249903975854 ko00920 Sulfur metabolism 3/491 10/7206 0.0263059727879 ko04015 Rap1 signaling pathway 10/491 278/7206 0.0282088654436 ko00040 Pentose and glucuronate interconversions 5/491 26/7206 0.028720746477 ko00310 Lysine degradation 10/491 73/7206 0.0309902152011 ko05144 Malaria 7/491 45/7206 0.031046654373 ko04111 Cell cycle - yeast 1/491 90/7206 0.0312867667308 ko05322 Systemic lupus erythematosus 4/491 151/7206 0.0338918932985 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/491 11/7206 0.0343789744013 ko04070 Phosphatidylinositol signaling system 2/491 112/7206 0.0345217142358 ko04152 AMPK signaling pathway 18/491 161/7206 0.0375755810917 ko00270 Cysteine and methionine metabolism 7/491 47/7206 0.0383178263847 ko04721 Synaptic vesicle cycle 1/491 80/7206 0.0427223643129 ko04964 Proximal tubule bicarbonate reclamation 5/491 29/7206 0.0438976181296 ko04914 Progesterone-mediated oocyte maturation 2/491 104/7206 0.0472508418615 ko04371 Apelin signaling pathway 19/491 177/7206 0.0475983388612 ko04270 Vascular smooth muscle contraction 17/491 154/7206 0.0497342695055