ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	178/1062	423/7206	1.74860890877e-45
ko05033	Nicotine addiction	44/1062	56/7206	1.10318185254e-26
ko04724	Glutamatergic synapse	77/1062	152/7206	4.82596564946e-26
ko05032	Morphine addiction	60/1062	110/7206	1.10256506853e-22
ko04721	Synaptic vesicle cycle	48/1062	80/7206	8.84511605127e-21
ko04728	Dopaminergic synapse	77/1062	185/7206	2.13722386519e-19
ko04727	GABAergic synapse	56/1062	110/7206	2.35905488754e-19
ko04713	Circadian entrainment	62/1062	136/7206	3.41709986631e-18
ko04725	Cholinergic synapse	67/1062	160/7206	3.53121678851e-17
ko04723	Retrograde endocannabinoid signaling	70/1062	175/7206	1.27348076423e-16
ko04024	cAMP signaling pathway	92/1062	279/7206	4.45698382711e-15
ko04742	Taste transduction	35/1062	61/7206	1.19559062388e-14
ko04911	Insulin secretion	50/1062	117/7206	1.53982251652e-13
ko04020	Calcium signaling pathway	84/1062	265/7206	1.23021600258e-12
ko04726	Serotonergic synapse	53/1062	137/7206	3.40573787667e-12
ko04921	Oxytocin signaling pathway	69/1062	209/7206	1.37224512492e-11
ko04360	Axon guidance	73/1062	233/7206	5.62303321198e-11
ko04261	Adrenergic signaling in cardiomyocytes	65/1062	205/7206	3.79841845978e-10
ko05031	Amphetamine addiction	37/1062	91/7206	1.28661446186e-09
ko03040	Spliceosome	1/1062	145/7206	3.54006877561e-09
ko04010	MAPK signaling pathway	82/1062	321/7206	1.91377506161e-07
ko04970	Salivary secretion	34/1062	95/7206	2.50153721846e-07
ko04720	Long-term potentiation	35/1062	99/7206	3.59856216214e-07
ko05030	Cocaine addiction	28/1062	73/7206	5.63625835143e-07
ko05164	Influenza A	5/1062	167/7206	7.13449241428e-07
ko03013	RNA transport	5/1062	166/7206	1.10131935558e-06
ko05322	Systemic lupus erythematosus	4/1062	151/7206	1.14555256452e-06
ko05168	Herpes simplex infection	7/1062	182/7206	2.2497176035e-06
ko04744	Phototransduction	17/1062	36/7206	3.43790987134e-06
ko04060	Cytokine-cytokine receptor interaction	8/1062	191/7206	3.70793684796e-06
ko04925	Aldosterone synthesis and secretion	34/1062	105/7206	4.42229089421e-06
ko05203	Viral carcinogenesis	17/1062	277/7206	8.59475471391e-06
ko04971	Gastric acid secretion	31/1062	98/7206	1.8632866271e-05
ko04120	Ubiquitin mediated proteolysis	5/1062	138/7206	2.92098580595e-05
ko04141	Protein processing in endoplasmic reticulum	9/1062	184/7206	3.11632819721e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1062	74/7206	3.73695579621e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1062	79/7206	3.8634933133e-05
ko04514	Cell adhesion molecules (CAMs)	37/1062	130/7206	4.66484399896e-05
ko04621	NOD-like receptor signaling pathway	7/1062	157/7206	5.35361754021e-05
ko04014	Ras signaling pathway	66/1062	279/7206	6.39969590856e-05
ko04610	Complement and coagulation cascades	1/1062	79/7206	8.2115617075e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1062	79/7206	8.2115617075e-05
ko04972	Pancreatic secretion	32/1062	111/7206	0.000116159324674
ko04966	Collecting duct acid secretion	12/1062	26/7206	0.000128368629891
ko04740	Olfactory transduction	25/1062	80/7206	0.000169637655346
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1062	59/7206	0.000255371862868
ko04022	cGMP-PKG signaling pathway	52/1062	216/7206	0.000271340619596
ko04730	Long-term depression	24/1062	78/7206	0.000283018951257
ko04070	Phosphatidylinositol signaling system	31/1062	112/7206	0.000374185603991
ko04260	Cardiac muscle contraction	28/1062	98/7206	0.000433775377127
ko04745	Phototransduction - fly	14/1062	38/7206	0.000631829211504
ko04612	Antigen processing and presentation	2/1062	77/7206	0.000945671097685
ko05162	Measles	6/1062	120/7206	0.00105425725219
ko04750	Inflammatory mediator regulation of TRP channels	31/1062	122/7206	0.00177162586562
ko04924	Renin secretion	24/1062	86/7206	0.0017955888797
ko05110	Vibrio cholerae infection	19/1062	63/7206	0.00180675693121
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1062	14/7206	0.00196398067989
ko04540	Gap junction	32/1062	128/7206	0.00224164317309
ko00280	Valine, leucine and isoleucine degradation	1/1062	54/7206	0.00320804235436
ko04146	Peroxisome	4/1062	89/7206	0.0037566094929
ko05205	Proteoglycans in cancer	24/1062	271/7206	0.00389061709672
ko00240	Pyrimidine metabolism	6/1062	110/7206	0.00397097273464
ko04640	Hematopoietic cell lineage	2/1062	64/7206	0.00420595811054
ko05414	Dilated cardiomyopathy	28/1062	112/7206	0.00428861560596
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1062	182/7206	0.0055714599091
ko00330	Arginine and proline metabolism	2/1062	61/7206	0.0061294560959
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1062	100/7206	0.0063827260217
ko05169	Epstein-Barr virus infection	17/1062	206/7206	0.0067826717735
ko04214	Apoptosis - fly	3/1062	72/7206	0.00694032939287
ko00310	Lysine degradation	3/1062	73/7206	0.00704758045086
ko04217	Necroptosis	14/1062	178/7206	0.00714643259769
ko05144	Malaria	1/1062	45/7206	0.0106148725932
ko00071	Fatty acid degradation	1/1062	45/7206	0.0106148725932
ko04072	Phospholipase D signaling pathway	42/1062	197/7206	0.0107008948486
ko03420	Nucleotide excision repair	1/1062	46/7206	0.0107369798127
ko04015	Rap1 signaling pathway	56/1062	278/7206	0.012150009915
ko04110	Cell cycle	11/1062	145/7206	0.0124409780069
ko04064	NF-kappa B signaling pathway	6/1062	96/7206	0.0136285908526
ko04657	IL-17 signaling pathway	5/1062	87/7206	0.0141624132343
ko05133	Pertussis	5/1062	87/7206	0.0141624132343
ko00983	Drug metabolism - other enzymes	1/1062	42/7206	0.0158002049177
ko03022	Basal transcription factors	1/1062	44/7206	0.0164166048501
ko04630	Jak-STAT signaling pathway	10/1062	132/7206	0.0178783480322
ko03018	RNA degradation	5/1062	84/7206	0.0193931353104
ko00561	Glycerolipid metabolism	3/1062	63/7206	0.0197632504999
ko05140	Leishmaniasis	4/1062	75/7206	0.0203308773425
ko05215	Prostate cancer	8/1062	111/7206	0.0213278158218
ko05161	Hepatitis B	15/1062	173/7206	0.0220911855578
ko01200	Carbon metabolism	10/1062	128/7206	0.0231878186549
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1062	40/7206	0.0235180940113
ko04371	Apelin signaling pathway	37/1062	177/7206	0.0237712722765
ko04915	Estrogen signaling pathway	29/1062	131/7206	0.0241328046983
ko04210	Apoptosis	16/1062	180/7206	0.0248038196411
ko00380	Tryptophan metabolism	2/1062	50/7206	0.0267832917725
ko05131	Shigellosis	5/1062	82/7206	0.0267914092275
ko00590	Arachidonic acid metabolism	2/1062	52/7206	0.0279837122401
ko04622	RIG-I-like receptor signaling pathway	3/1062	62/7206	0.0286109869432
ko00512	Mucin type O-glycan biosynthesis	9/1062	29/7206	0.0295829498498
ko04964	Proximal tubule bicarbonate reclamation	9/1062	29/7206	0.0295829498498
ko04620	Toll-like receptor signaling pathway	7/1062	100/7206	0.0316056540366
ko00982	Drug metabolism - cytochrome P450	1/1062	37/7206	0.0347595290546
ko03320	PPAR signaling pathway	4/1062	69/7206	0.0385337866791
ko05219	Bladder cancer	2/1062	48/7206	0.0387842344777
ko04658	Th1 and Th2 cell differentiation	7/1062	96/7206	0.0411016740419
ko05166	HTLV-I infection	31/1062	292/7206	0.0429353391675
ko04611	Platelet activation	15/1062	163/7206	0.0439250971742
ko04140	Autophagy - animal	15/1062	164/7206	0.0441177901067
ko04973	Carbohydrate digestion and absorption	11/1062	42/7206	0.0469740614136
ko04115	p53 signaling pathway	5/1062	74/7206	0.0484936403563
ko00562	Inositol phosphate metabolism	20/1062	89/7206	0.0489436736177
ko01524	Platinum drug resistance	5/1062	76/7206	0.0490439306222