ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 67/787 152/7206 4.63045355537e-26 ko05033 Nicotine addiction 39/787 56/7206 2.09128041842e-25 ko05032 Morphine addiction 52/787 110/7206 3.64448676695e-22 ko04727 GABAergic synapse 49/787 110/7206 1.46325223854e-19 ko04728 Dopaminergic synapse 63/787 185/7206 1.37591475362e-17 ko04080 Neuroactive ligand-receptor interaction 105/787 423/7206 5.17699555775e-17 ko04713 Circadian entrainment 51/787 136/7206 1.95741744555e-16 ko04024 cAMP signaling pathway 77/787 279/7206 2.35966603172e-15 ko04723 Retrograde endocannabinoid signaling 57/787 175/7206 4.96551183261e-15 ko04721 Synaptic vesicle cycle 34/787 80/7206 3.27001138052e-13 ko04744 Phototransduction 21/787 36/7206 5.58180219651e-12 ko04725 Cholinergic synapse 49/787 160/7206 5.84652911942e-12 ko04360 Axon guidance 58/787 233/7206 7.43397259439e-10 ko05030 Cocaine addiction 27/787 73/7206 3.81953435923e-09 ko04742 Taste transduction 24/787 61/7206 6.75001498292e-09 ko04726 Serotonergic synapse 39/787 137/7206 9.10204095507e-09 ko04911 Insulin secretion 34/787 117/7206 4.70220859737e-08 ko04261 Adrenergic signaling in cardiomyocytes 49/787 205/7206 7.54257720386e-08 ko05031 Amphetamine addiction 27/787 91/7206 7.25192028332e-07 ko04921 Oxytocin signaling pathway 47/787 209/7206 1.30468803111e-06 ko04010 MAPK signaling pathway 64/787 321/7206 1.36058942979e-06 ko03013 RNA transport 2/787 166/7206 1.69759119153e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 23/787 74/7206 1.97756561225e-06 ko04020 Calcium signaling pathway 53/787 265/7206 1.19072763654e-05 ko03040 Spliceosome 2/787 145/7206 1.846046704e-05 ko04730 Long-term depression 22/787 78/7206 1.88646482802e-05 ko04060 Cytokine-cytokine receptor interaction 5/787 191/7206 2.85518466581e-05 ko05203 Viral carcinogenesis 11/787 277/7206 3.19939500597e-05 ko04720 Long-term potentiation 25/787 99/7206 5.14126691746e-05 ko04970 Salivary secretion 24/787 95/7206 7.42574190356e-05 ko04514 Cell adhesion molecules (CAMs) 29/787 130/7206 0.000158780643282 ko05164 Influenza A 5/787 167/7206 0.00022974132903 ko05322 Systemic lupus erythematosus 4/787 151/7206 0.000291397580961 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/787 79/7206 0.000333094328564 ko04022 cGMP-PKG signaling pathway 40/787 216/7206 0.000781513808652 ko04120 Ubiquitin mediated proteolysis 4/787 138/7206 0.000810341230059 ko04260 Cardiac muscle contraction 22/787 98/7206 0.000853868868635 ko04391 Hippo signaling pathway - fly 21/787 90/7206 0.000884013967817 ko03018 RNA degradation 1/787 84/7206 0.00120184825243 ko04621 NOD-like receptor signaling pathway 6/787 157/7206 0.00179680854439 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/787 14/7206 0.00230893265779 ko04740 Olfactory transduction 18/787 80/7206 0.00303891110846 ko05162 Measles 4/787 120/7206 0.00449138385369 ko04972 Pancreatic secretion 22/787 111/7206 0.00512485604509 ko05205 Proteoglycans in cancer 16/787 271/7206 0.00524124187615 ko04146 Peroxisome 2/787 89/7206 0.00524994014901 ko05414 Dilated cardiomyopathy 22/787 112/7206 0.00547210276552 ko04141 Protein processing in endoplasmic reticulum 9/787 184/7206 0.00556993881227 ko01200 Carbon metabolism 5/787 128/7206 0.0063116536433 ko05169 Epstein-Barr virus infection 11/787 206/7206 0.006368189336 ko05168 Herpes simplex infection 9/787 182/7206 0.00754752997978 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/787 182/7206 0.00754752997978 ko04924 Renin secretion 18/787 86/7206 0.00775707826759 ko04014 Ras signaling pathway 45/787 279/7206 0.0078508402061 ko04915 Estrogen signaling pathway 24/787 131/7206 0.0102151463158 ko04964 Proximal tubule bicarbonate reclamation 8/787 29/7206 0.0103723382124 ko00561 Glycerolipid metabolism 1/787 63/7206 0.012778524782 ko04930 Type II diabetes mellitus 12/787 54/7206 0.0138996239405 ko04071 Sphingolipid signaling pathway 28/787 162/7206 0.0145928862204 ko04110 Cell cycle 7/787 145/7206 0.0147739708423 ko05140 Leishmaniasis 2/787 75/7206 0.0147922545021 ko00515 Mannose type O-glycan biosynthesis 7/787 25/7206 0.0148854421581 ko04612 Antigen processing and presentation 2/787 77/7206 0.0151765118405 ko04217 Necroptosis 10/787 178/7206 0.0200887668508 ko05145 Toxoplasmosis 6/787 126/7206 0.0208070460615 ko04214 Apoptosis - fly 2/787 72/7206 0.0212107054496 ko01230 Biosynthesis of amino acids 3/787 85/7206 0.0223430972488 ko00564 Glycerophospholipid metabolism 4/787 99/7206 0.0224479836075 ko05133 Pertussis 3/787 87/7206 0.0227709456122 ko04925 Aldosterone synthesis and secretion 19/787 105/7206 0.0258121842462 ko05034 Alcoholism 37/787 238/7206 0.0258705270724 ko00240 Pyrimidine metabolism 5/787 110/7206 0.0297141435687 ko04064 NF-kappa B signaling pathway 4/787 96/7206 0.0308795597116 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/787 59/7206 0.0324266076111 ko05410 Hypertrophic cardiomyopathy (HCM) 18/787 100/7206 0.033705047509 ko04630 Jak-STAT signaling pathway 7/787 132/7206 0.0341391294464 ko00380 Tryptophan metabolism 1/787 50/7206 0.0386924802371 ko04973 Carbohydrate digestion and absorption 9/787 42/7206 0.042180121725 ko04640 Hematopoietic cell lineage 2/787 64/7206 0.0426170435133 ko00190 Oxidative phosphorylation 7/787 127/7206 0.0448312181135 ko04015 Rap1 signaling pathway 41/787 278/7206 0.0490090475659