ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 22/208 152/7206 2.98682060781e-10 ko04915 Estrogen signaling pathway 16/208 131/7206 9.63403320923e-07 ko04728 Dopaminergic synapse 19/208 185/7206 1.35541987007e-06 ko04713 Circadian entrainment 16/208 136/7206 1.60150796207e-06 ko04925 Aldosterone synthesis and secretion 14/208 105/7206 1.62618117902e-06 ko05032 Morphine addiction 14/208 110/7206 2.86659004131e-06 ko04725 Cholinergic synapse 17/208 160/7206 3.13601870388e-06 ko04070 Phosphatidylinositol signaling system 14/208 112/7206 3.56265758865e-06 ko04720 Long-term potentiation 13/208 99/7206 4.60422944158e-06 ko04911 Insulin secretion 14/208 117/7206 6.00308562713e-06 ko05030 Cocaine addiction 11/208 73/7206 6.58881300652e-06 ko04020 Calcium signaling pathway 22/208 265/7206 6.96240343953e-06 ko04912 GnRH signaling pathway 14/208 122/7206 9.82817380539e-06 ko05031 Amphetamine addiction 12/208 91/7206 1.03397386349e-05 ko04072 Phospholipase D signaling pathway 18/208 197/7206 1.35966877962e-05 ko04727 GABAergic synapse 13/208 110/7206 1.49187040629e-05 ko04261 Adrenergic signaling in cardiomyocytes 18/208 205/7206 2.34341381726e-05 ko04022 cGMP-PKG signaling pathway 18/208 216/7206 4.71954575128e-05 ko04540 Gap junction 13/208 128/7206 7.5393649962e-05 ko05231 Choline metabolism in cancer 13/208 134/7206 0.000120912562792 ko04723 Retrograde endocannabinoid signaling 15/208 175/7206 0.000150027019398 ko04918 Thyroid hormone synthesis 10/208 86/7206 0.000168842885148 ko04914 Progesterone-mediated oocyte maturation 11/208 104/7206 0.000188763989866 ko04730 Long-term depression 9/208 78/7206 0.000379487732608 ko04010 MAPK signaling pathway 21/208 321/7206 0.000425218277728 ko04024 cAMP signaling pathway 19/208 279/7206 0.000659213145039 ko04062 Chemokine signaling pathway 15/208 201/7206 0.000670851244237 ko04211 Longevity regulating pathway 11/208 123/7206 0.000808431841602 ko04921 Oxytocin signaling pathway 15/208 209/7206 0.00100375784638 ko00562 Inositol phosphate metabolism 9/208 89/7206 0.00100618834677 ko04012 ErbB signaling pathway 10/208 109/7206 0.00114288720936 ko04270 Vascular smooth muscle contraction 12/208 154/7206 0.00159385988013 ko04923 Regulation of lipolysis in adipocytes 8/208 77/7206 0.00160327502627 ko04371 Apelin signaling pathway 13/208 177/7206 0.00176049678367 ko04971 Gastric acid secretion 9/208 98/7206 0.00199270515278 ko04916 Melanogenesis 11/208 142/7206 0.00259548677269 ko04750 Inflammatory mediator regulation of TRP channels 10/208 122/7206 0.00267108855872 ko01522 Endocrine resistance 10/208 124/7206 0.00300880407833 ko04213 Longevity regulating pathway - multiple species 8/208 86/7206 0.0032415742111 ko04080 Neuroactive ligand-receptor interaction 23/208 423/7206 0.00379460158572 ko05033 Nicotine addiction 6/208 56/7206 0.00524976593387 ko04970 Salivary secretion 8/208 95/7206 0.00595802814857 ko04726 Serotonergic synapse 10/208 137/7206 0.0061193431599 ko00513 Various types of N-glycan biosynthesis 5/208 42/7206 0.00681472712742 ko04611 Platelet activation 11/208 163/7206 0.00737533816272 ko05214 Glioma 7/208 79/7206 0.00753947926415 ko00564 Glycerophospholipid metabolism 8/208 99/7206 0.00761098965972 ko04742 Taste transduction 6/208 61/7206 0.007972736327 ko04740 Olfactory transduction 7/208 80/7206 0.00806570121712 ko04360 Axon guidance 14/208 233/7206 0.00832024950006 ko04666 Fc gamma R-mediated phagocytosis 9/208 122/7206 0.00853895007165 ko05230 Central carbon metabolism in cancer 7/208 81/7206 0.00861854342025 ko04015 Rap1 signaling pathway 16/208 278/7206 0.0088100673902 ko00512 Mucin type O-glycan biosynthesis 4/208 29/7206 0.00909399447486 ko05034 Alcoholism 14/208 238/7206 0.00962968439987 ko01521 EGFR tyrosine kinase inhibitor resistance 8/208 106/7206 0.0113050629667 ko04922 Glucagon signaling pathway 9/208 128/7206 0.0115158215201 ko04320 Dorso-ventral axis formation 4/208 31/7206 0.011520272805 ko05142 Chagas disease (American trypanosomiasis) 9/208 130/7206 0.0126630085461 ko00510 N-Glycan biosynthesis 5/208 50/7206 0.014104681307 ko05414 Dilated cardiomyopathy 8/208 112/7206 0.0154059707782 ko04011 MAPK signaling pathway - yeast 5/208 53/7206 0.0178275055595 ko04114 Oocyte meiosis 9/208 139/7206 0.0189028018226 ko04722 Neurotrophin signaling pathway 10/208 160/7206 0.0259151923024 ko04961 Endocrine and other factor-regulated calcium reabsorption 5/208 59/7206 0.0270985383791 ko04144 Endocytosis 17/208 342/7206 0.029126681306 ko04973 Carbohydrate digestion and absorption 4/208 42/7206 0.0320923920094 ko00515 Mannose type O-glycan biosynthesis 3/208 25/7206 0.0341687301612 ko04913 Ovarian steroidogenesis 5/208 63/7206 0.0347199755506 ko00561 Glycerolipid metabolism 5/208 63/7206 0.0347199755506 ko04924 Renin secretion 6/208 86/7206 0.0374849719782 ko04917 Prolactin signaling pathway 6/208 87/7206 0.0393329617413 ko04972 Pancreatic secretion 7/208 111/7206 0.041091201327 ko05223 Non-small cell lung cancer 5/208 66/7206 0.0412265490829 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/208 28/7206 0.0457159091653