ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 35/247 134/7206 5.20947274695e-22 ko04621 NOD-like receptor signaling pathway 34/247 157/7206 1.34859542877e-18 ko04668 TNF signaling pathway 29/247 120/7206 2.29770185572e-17 ko04064 NF-kappa B signaling pathway 25/247 96/7206 6.16655356951e-16 ko04060 Cytokine-cytokine receptor interaction 34/247 191/7206 8.01180117185e-16 ko05164 Influenza A 29/247 167/7206 2.44834201594e-13 ko05140 Leishmaniasis 20/247 75/7206 3.48560811295e-13 ko05161 Hepatitis B 29/247 173/7206 6.2519132273e-13 ko05321 Inflammatory bowel disease (IBD) 17/247 56/7206 2.13719888224e-12 ko05168 Herpes simplex infection 29/247 182/7206 2.36114843597e-12 ko04620 Toll-like receptor signaling pathway 21/247 100/7206 1.34675760405e-11 ko04217 Necroptosis 26/247 178/7206 2.56754450476e-10 ko05162 Measles 21/247 120/7206 5.01296816034e-10 ko04630 Jak-STAT signaling pathway 22/247 132/7206 5.05595193459e-10 ko05152 Tuberculosis 25/247 187/7206 3.85475143438e-09 ko04657 IL-17 signaling pathway 17/247 87/7206 4.16222656739e-09 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/247 191/7206 6.00722286121e-09 ko04623 Cytosolic DNA-sensing pathway 12/247 41/7206 6.58285095337e-09 ko05145 Toxoplasmosis 20/247 126/7206 7.72179208886e-09 ko04622 RIG-I-like receptor signaling pathway 14/247 62/7206 1.43324825206e-08 ko05133 Pertussis 16/247 87/7206 3.00637882684e-08 ko05323 Rheumatoid arthritis 16/247 89/7206 4.21285244591e-08 ko05160 Hepatitis C 21/247 153/7206 4.55790271741e-08 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/247 135/7206 1.36589772403e-07 ko05144 Malaria 11/247 45/7206 2.22179048422e-07 ko05142 Chagas disease (American trypanosomiasis) 18/247 130/7206 3.79331342207e-07 ko05134 Legionellosis 13/247 74/7206 1.06776756042e-06 ko05166 HTLV-I infection 27/247 292/7206 2.10458798319e-06 ko04659 Th17 cell differentiation 15/247 106/7206 2.76323857793e-06 ko04660 T cell receptor signaling pathway 16/247 124/7206 4.42718320875e-06 ko05340 Primary immunodeficiency 8/247 30/7206 5.17521220434e-06 ko05132 Salmonella infection 14/247 98/7206 5.33596269955e-06 ko04210 Apoptosis 19/247 180/7206 1.14278862259e-05 ko04658 Th1 and Th2 cell differentiation 13/247 96/7206 2.1029869259e-05 ko04650 Natural killer cell mediated cytotoxicity 13/247 97/7206 2.35546556878e-05 ko04672 Intestinal immune network for IgA production 8/247 37/7206 2.77209109967e-05 ko04662 B cell receptor signaling pathway 12/247 88/7206 4.08421825956e-05 ko05169 Epstein-Barr virus infection 18/247 206/7206 0.000232756151093 ko04610 Complement and coagulation cascades 10/247 79/7206 0.000335186408599 ko04062 Chemokine signaling pathway 17/247 201/7206 0.000507546785493 ko04917 Prolactin signaling pathway 10/247 87/7206 0.000732245212609 ko04010 MAPK signaling pathway 23/247 321/7206 0.000745891041296 ko05418 Fluid shear stress and atherosclerosis 15/247 173/7206 0.000835490975132 ko04066 HIF-1 signaling pathway 12/247 123/7206 0.000989643716221 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/247 182/7206 0.00140237494238 ko04080 Neuroactive ligand-receptor interaction 4/247 423/7206 0.00141310817817 ko05146 Amoebiasis 10/247 99/7206 0.00199140842925 ko04666 Fc gamma R-mediated phagocytosis 11/247 122/7206 0.00299559399608 ko04920 Adipocytokine signaling pathway 9/247 89/7206 0.00328324492326 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/247 92/7206 0.00410646957238 ko04612 Antigen processing and presentation 8/247 77/7206 0.0046430449774 ko04664 Fc epsilon RI signaling pathway 8/247 77/7206 0.0046430449774 ko04670 Leukocyte transendothelial migration 12/247 151/7206 0.00553952434683 ko04931 Insulin resistance 11/247 137/7206 0.00721288324229 ko05330 Allograft rejection 4/247 24/7206 0.00833590669636 ko05203 Viral carcinogenesis 18/247 277/7206 0.00998680404671 ko04145 Phagosome 12/247 162/7206 0.0128453675621 ko04915 Estrogen signaling pathway 10/247 131/7206 0.0142428085695 ko05320 Autoimmune thyroid disease 4/247 29/7206 0.0163054208393 ko05310 Asthma 3/247 17/7206 0.018952146591 ko04218 Cellular senescence 12/247 177/7206 0.0202205238179 ko05131 Shigellosis 7/247 82/7206 0.021889137771 ko05332 Graft-versus-host disease 3/247 18/7206 0.0221785164636 ko04940 Type I diabetes mellitus 4/247 32/7206 0.0227974702636 ko05143 African trypanosomiasis 4/247 32/7206 0.0227974702636 ko05212 Pancreatic cancer 7/247 83/7206 0.0232325335282 ko04624 Toll and Imd signaling pathway 5/247 49/7206 0.0253926694796 ko05222 Small cell lung cancer 7/247 89/7206 0.0324991997917 ko05150 Staphylococcus aureus infection 4/247 36/7206 0.0335984905123 ko04930 Type II diabetes mellitus 5/247 54/7206 0.0367388160904 ko01522 Endocrine resistance 9/247 124/7206 0.0389441952852 ko04115 p53 signaling pathway 6/247 74/7206 0.0406903684547