ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1085	423/7206	1.81985149759e-55
ko05033	Nicotine addiction	50/1085	56/7206	3.76468961854e-35
ko04724	Glutamatergic synapse	85/1085	152/7206	3.94579696182e-32
ko05032	Morphine addiction	68/1085	110/7206	1.53173567394e-29
ko04713	Circadian entrainment	75/1085	136/7206	6.6325849982e-28
ko04727	GABAergic synapse	66/1085	110/7206	1.3258836073e-27
ko04728	Dopaminergic synapse	81/1085	185/7206	1.9492605342e-21
ko04725	Cholinergic synapse	73/1085	160/7206	1.07731768401e-20
ko04723	Retrograde endocannabinoid signaling	77/1085	175/7206	1.38976761512e-20
ko04721	Synaptic vesicle cycle	47/1085	80/7206	1.93435689697e-19
ko04024	cAMP signaling pathway	99/1085	279/7206	5.42057282438e-18
ko04020	Calcium signaling pathway	95/1085	265/7206	1.48867298586e-17
ko04911	Insulin secretion	56/1085	117/7206	2.57930001957e-17
ko04742	Taste transduction	36/1085	61/7206	2.87415383958e-15
ko04744	Phototransduction	26/1085	36/7206	1.77751437246e-14
ko04726	Serotonergic synapse	56/1085	137/7206	1.32913623709e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1085	205/7206	1.35125137372e-12
ko04921	Oxytocin signaling pathway	72/1085	209/7206	1.8824280962e-12
ko05031	Amphetamine addiction	40/1085	91/7206	2.93747843434e-11
ko04720	Long-term potentiation	41/1085	99/7206	1.6251681673e-10
ko03040	Spliceosome	1/1085	145/7206	2.2185573435e-09
ko04970	Salivary secretion	37/1085	95/7206	9.62829312188e-09
ko05030	Cocaine addiction	30/1085	73/7206	5.84012023223e-08
ko04925	Aldosterone synthesis and secretion	38/1085	105/7206	9.4351059566e-08
ko05203	Viral carcinogenesis	14/1085	277/7206	1.82788829343e-07
ko04971	Gastric acid secretion	35/1085	98/7206	4.02964596452e-07
ko04360	Axon guidance	64/1085	233/7206	8.66715417668e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1085	74/7206	1.21743881382e-06
ko04060	Cytokine-cytokine receptor interaction	8/1085	191/7206	1.7482118778e-06
ko04972	Pancreatic secretion	36/1085	111/7206	3.16181625057e-06
ko05322	Systemic lupus erythematosus	5/1085	151/7206	4.63373953301e-06
ko04141	Protein processing in endoplasmic reticulum	8/1085	184/7206	5.06402465785e-06
ko04022	cGMP-PKG signaling pathway	58/1085	216/7206	6.53601089848e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1085	79/7206	7.78655323621e-06
ko05164	Influenza A	7/1085	167/7206	9.05039021537e-06
ko04740	Olfactory transduction	28/1085	80/7206	9.18310263451e-06
ko04010	MAPK signaling pathway	78/1085	321/7206	9.39050274127e-06
ko04745	Phototransduction - fly	17/1085	38/7206	1.15271369642e-05
ko04072	Phospholipase D signaling pathway	53/1085	197/7206	1.15401166592e-05
ko03013	RNA transport	7/1085	166/7206	1.3234511692e-05
ko04514	Cell adhesion molecules (CAMs)	38/1085	130/7206	3.11202739716e-05
ko05414	Dilated cardiomyopathy	33/1085	112/7206	8.34684202407e-05
ko04070	Phosphatidylinositol signaling system	33/1085	112/7206	8.34684202407e-05
ko04260	Cardiac muscle contraction	30/1085	98/7206	8.36442362628e-05
ko04621	NOD-like receptor signaling pathway	8/1085	157/7206	0.000109030639955
ko05168	Herpes simplex infection	11/1085	182/7206	0.000211118110883
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1085	59/7206	0.000300647410722
ko05169	Epstein-Barr virus infection	14/1085	206/7206	0.000340422931972
ko04730	Long-term depression	24/1085	78/7206	0.000359774733671
ko03008	Ribosome biogenesis in eukaryotes	2/1085	79/7206	0.000413569702156
ko04750	Inflammatory mediator regulation of TRP channels	33/1085	122/7206	0.000498130917675
ko04110	Cell cycle	8/1085	145/7206	0.000571899553311
ko04612	Antigen processing and presentation	2/1085	77/7206	0.000610136296378
ko05205	Proteoglycans in cancer	22/1085	271/7206	0.000685760169247
ko04966	Collecting duct acid secretion	11/1085	26/7206	0.000747478797932
ko05140	Leishmaniasis	2/1085	75/7206	0.000913098816615
ko05110	Vibrio cholerae infection	20/1085	63/7206	0.00103125743022
ko04120	Ubiquitin mediated proteolysis	8/1085	138/7206	0.0010571853846
ko04711	Circadian rhythm - fly	7/1085	13/7206	0.00128193378436
ko04064	NF-kappa B signaling pathway	4/1085	96/7206	0.00131256525377
ko04540	Gap junction	33/1085	128/7206	0.00159128751396
ko04924	Renin secretion	24/1085	86/7206	0.00203347888462
ko00520	Amino sugar and nucleotide sugar metabolism	1/1085	55/7206	0.00209757933293
ko04610	Complement and coagulation cascades	3/1085	79/7206	0.00232897981908
ko04146	Peroxisome	4/1085	89/7206	0.00258177066113
ko05162	Measles	7/1085	120/7206	0.00277936802481
ko00590	Arachidonic acid metabolism	1/1085	52/7206	0.00314903256941
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1085	182/7206	0.00319423278764
ko05161	Hepatitis B	13/1085	173/7206	0.00348540620111
ko04710	Circadian rhythm	14/1085	43/7206	0.00394853178944
ko04976	Bile secretion	22/1085	80/7206	0.00400722408977
ko04915	Estrogen signaling pathway	32/1085	131/7206	0.00428126369787
ko04350	TGF-beta signaling pathway	6/1085	103/7206	0.0052697970693
ko04014	Ras signaling pathway	59/1085	279/7206	0.00606839896587
ko00240	Pyrimidine metabolism	7/1085	110/7206	0.00698138717864
ko04657	IL-17 signaling pathway	5/1085	87/7206	0.0101499901037
ko05133	Pertussis	5/1085	87/7206	0.0101499901037
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1085	100/7206	0.0103478615722
ko03022	Basal transcription factors	1/1085	44/7206	0.0104805893577
ko05144	Malaria	1/1085	45/7206	0.0105887820274
ko00071	Fatty acid degradation	1/1085	45/7206	0.0105887820274
ko03420	Nucleotide excision repair	1/1085	46/7206	0.0110081169765
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1085	14/7206	0.0116621368968
ko00480	Glutathione metabolism	2/1085	55/7206	0.0127699244481
ko05321	Inflammatory bowel disease (IBD)	2/1085	56/7206	0.0130789922796
ko04658	Th1 and Th2 cell differentiation	6/1085	96/7206	0.0136531056969
ko04371	Apelin signaling pathway	39/1085	177/7206	0.0138180342671
ko04640	Hematopoietic cell lineage	3/1085	64/7206	0.0138604358922
ko03018	RNA degradation	5/1085	84/7206	0.0139852576233
ko04140	Autophagy - animal	14/1085	164/7206	0.0150481374393
ko00140	Steroid hormone biosynthesis	1/1085	41/7206	0.0156334448775
ko05215	Prostate cancer	8/1085	111/7206	0.015910207
ko05418	Fluid shear stress and atherosclerosis	15/1085	173/7206	0.0173360819569
ko05131	Shigellosis	5/1085	82/7206	0.0191553380371
ko04217	Necroptosis	16/1085	178/7206	0.0194065402125
ko04930	Type II diabetes mellitus	15/1085	54/7206	0.0195247998312
ko04622	RIG-I-like receptor signaling pathway	3/1085	62/7206	0.0195631217728
ko04210	Apoptosis	16/1085	180/7206	0.0196235282592
ko04214	Apoptosis - fly	4/1085	72/7206	0.0196768430165
ko00310	Lysine degradation	4/1085	73/7206	0.01992045344
ko04912	GnRH signaling pathway	28/1085	122/7206	0.0206121046396
ko04923	Regulation of lipolysis in adipocytes	19/1085	77/7206	0.023999506563
ko04071	Sphingolipid signaling pathway	35/1085	162/7206	0.0254944556492
ko05016	Huntington's disease	21/1085	215/7206	0.0258383507717
ko04630	Jak-STAT signaling pathway	11/1085	132/7206	0.026791130964
ko04510	Focal adhesion	24/1085	240/7206	0.0271025925177
ko00330	Arginine and proline metabolism	3/1085	61/7206	0.0286191870835
ko05166	HTLV-I infection	31/1085	292/7206	0.029683823437
ko04964	Proximal tubule bicarbonate reclamation	9/1085	29/7206	0.0313337933423
ko00562	Inositol phosphate metabolism	21/1085	89/7206	0.0350657649847
ko01524	Platinum drug resistance	5/1085	76/7206	0.0355265489689
ko03410	Base excision repair	1/1085	38/7206	0.0364062629135
ko05231	Choline metabolism in cancer	29/1085	134/7206	0.0376482308471
ko00620	Pyruvate metabolism	2/1085	46/7206	0.038061457895
ko00260	Glycine, serine and threonine metabolism	2/1085	48/7206	0.0395671402784
ko05219	Bladder cancer	2/1085	48/7206	0.0395671402784
ko04626	Plant-pathogen interaction	6/1085	18/7206	0.0423785689569
ko04218	Cellular senescence	17/1085	177/7206	0.0425393498599
ko05145	Toxoplasmosis	11/1085	126/7206	0.0441987357534
ko04918	Thyroid hormone synthesis	20/1085	86/7206	0.0466354105609
ko04620	Toll-like receptor signaling pathway	8/1085	100/7206	0.0480337015058
ko04115	p53 signaling pathway	5/1085	74/7206	0.0483717548735
ko04142	Lysosome	14/1085	151/7206	0.0496459997393