ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	132/600	423/7206	1.39183663286e-45
ko05033	Nicotine addiction	40/600	56/7206	2.27066625625e-31
ko04724	Glutamatergic synapse	64/600	152/7206	2.06036027218e-30
ko04727	GABAergic synapse	44/600	110/7206	4.22597632942e-20
ko05032	Morphine addiction	42/600	110/7206	2.4429935999e-18
ko04723	Retrograde endocannabinoid signaling	53/600	175/7206	1.26949975489e-17
ko04728	Dopaminergic synapse	54/600	185/7206	3.82185103607e-17
ko04024	cAMP signaling pathway	65/600	279/7206	5.05765950055e-15
ko04713	Circadian entrainment	42/600	136/7206	1.6169357358e-14
ko04726	Serotonergic synapse	41/600	137/7206	1.10638554471e-13
ko04020	Calcium signaling pathway	58/600	265/7206	2.82743580058e-12
ko04911	Insulin secretion	35/600	117/7206	7.49424331137e-12
ko04721	Synaptic vesicle cycle	28/600	80/7206	1.48740271311e-11
ko04742	Taste transduction	24/600	61/7206	2.46665462855e-11
ko05031	Amphetamine addiction	29/600	91/7206	8.88744295122e-11
ko04725	Cholinergic synapse	40/600	160/7206	1.17916212644e-10
ko04921	Oxytocin signaling pathway	46/600	209/7206	4.75375609144e-10
ko05030	Cocaine addiction	24/600	73/7206	1.88104773003e-09
ko04720	Long-term potentiation	27/600	99/7206	1.80447522761e-08
ko04261	Adrenergic signaling in cardiomyocytes	42/600	205/7206	4.01204553132e-08
ko04010	MAPK signaling pathway	56/600	321/7206	6.77919186075e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	21/600	74/7206	3.38541386949e-07
ko04970	Salivary secretion	23/600	95/7206	2.058962897e-06
ko04972	Pancreatic secretion	24/600	111/7206	1.02764722848e-05
ko04730	Long-term depression	19/600	78/7206	1.44631572131e-05
ko04514	Cell adhesion molecules (CAMs)	26/600	130/7206	3.05491698717e-05
ko04072	Phospholipase D signaling pathway	34/600	197/7206	3.53244785587e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	18/600	79/7206	6.31718753572e-05
ko05203	Viral carcinogenesis	7/600	277/7206	8.44614875654e-05
ko05164	Influenza A	2/600	167/7206	9.71640971849e-05
ko04260	Cardiac muscle contraction	20/600	98/7206	0.0001309993238
ko04120	Ubiquitin mediated proteolysis	1/600	138/7206	0.000132666667995
ko04925	Aldosterone synthesis and secretion	20/600	105/7206	0.000448520698607
ko04060	Cytokine-cytokine receptor interaction	4/600	191/7206	0.000467263233255
ko04971	Gastric acid secretion	19/600	98/7206	0.00057169229748
ko04360	Axon guidance	35/600	233/7206	0.000618692869309
ko05168	Herpes simplex infection	4/600	182/7206	0.000935357428343
ko05205	Proteoglycans in cancer	9/600	271/7206	0.0010723949673
ko04621	NOD-like receptor signaling pathway	3/600	157/7206	0.00113242560333
ko00240	Pyrimidine metabolism	1/600	110/7206	0.00137820719208
ko05322	Systemic lupus erythematosus	3/600	151/7206	0.00160496298074
ko04964	Proximal tubule bicarbonate reclamation	8/600	29/7206	0.00195936089606
ko03013	RNA transport	4/600	166/7206	0.00254066695141
ko04070	Phosphatidylinositol signaling system	19/600	112/7206	0.00268562780909
ko05414	Dilated cardiomyopathy	19/600	112/7206	0.00268562780909
ko04141	Protein processing in endoplasmic reticulum	5/600	184/7206	0.00268587436988
ko04540	Gap junction	21/600	128/7206	0.00298957192374
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/600	182/7206	0.0038273578062
ko05162	Measles	2/600	120/7206	0.00395239119417
ko04022	cGMP-PKG signaling pathway	30/600	216/7206	0.00543625634174
ko04630	Jak-STAT signaling pathway	3/600	132/7206	0.00636112080341
ko05169	Epstein-Barr virus infection	7/600	206/7206	0.00673298175042
ko04014	Ras signaling pathway	36/600	279/7206	0.00762073224181
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/600	59/7206	0.00853316818266
ko03018	RNA degradation	1/600	84/7206	0.00919755724493
ko04350	TGF-beta signaling pathway	2/600	103/7206	0.0113119055051
ko05034	Alcoholism	31/600	238/7206	0.0116750129639
ko04217	Necroptosis	6/600	178/7206	0.012603149862
ko03008	Ribosome biogenesis in eukaryotes	1/600	79/7206	0.013419594619
ko04915	Estrogen signaling pathway	19/600	131/7206	0.0155639145495
ko04924	Renin secretion	14/600	86/7206	0.0157902742607
ko04750	Inflammatory mediator regulation of TRP channels	18/600	122/7206	0.0187422185597
ko01524	Platinum drug resistance	1/600	76/7206	0.019712894063
ko04150	mTOR signaling pathway	7/600	184/7206	0.0209677281765
ko04550	Signaling pathways regulating pluripotency of stem cells	6/600	165/7206	0.0223075689562
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/600	14/7206	0.0242603021559
ko05410	Hypertrophic cardiomyopathy (HCM)	15/600	100/7206	0.026009655291
ko00310	Lysine degradation	1/600	73/7206	0.0296136611653
ko04140	Autophagy - animal	6/600	164/7206	0.0303766353113
ko02024	Quorum sensing	4/600	15/7206	0.0309588405866
ko04146	Peroxisome	2/600	89/7206	0.0322273944215
ko00190	Oxidative phosphorylation	4/600	127/7206	0.0332851158027
ko01200	Carbon metabolism	4/600	128/7206	0.033707996042
ko04015	Rap1 signaling pathway	33/600	278/7206	0.034919675956
ko05161	Hepatitis B	7/600	173/7206	0.0362142177357
ko04976	Bile secretion	12/600	80/7206	0.039635877888
ko04740	Olfactory transduction	12/600	80/7206	0.039635877888
ko05202	Transcriptional misregulation in cancer	8/600	188/7206	0.0434439980037
ko04940	Type I diabetes mellitus	6/600	32/7206	0.0456777833794