ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	167/1028	423/7206	3.64053354884e-40
ko05033	Nicotine addiction	45/1028	56/7206	1.15508467649e-28
ko04724	Glutamatergic synapse	79/1028	152/7206	1.16597238392e-28
ko04713	Circadian entrainment	68/1028	136/7206	1.60592404786e-23
ko04721	Synaptic vesicle cycle	48/1028	80/7206	2.12583571939e-21
ko04727	GABAergic synapse	56/1028	110/7206	4.86035087673e-20
ko05032	Morphine addiction	56/1028	110/7206	4.86035087673e-20
ko04725	Cholinergic synapse	66/1028	160/7206	2.79776774312e-17
ko04728	Dopaminergic synapse	72/1028	185/7206	4.33751055721e-17
ko04723	Retrograde endocannabinoid signaling	68/1028	175/7206	3.70328004947e-16
ko04742	Taste transduction	36/1028	61/7206	4.98652774168e-16
ko04911	Insulin secretion	51/1028	117/7206	8.69664531467e-15
ko04020	Calcium signaling pathway	86/1028	265/7206	1.46596373246e-14
ko04024	cAMP signaling pathway	88/1028	279/7206	6.59260362891e-14
ko04921	Oxytocin signaling pathway	69/1028	209/7206	2.81776609794e-12
ko04726	Serotonergic synapse	52/1028	137/7206	3.59544469288e-12
ko04970	Salivary secretion	40/1028	95/7206	2.69461564031e-11
ko04744	Phototransduction	22/1028	36/7206	1.03825583651e-10
ko05031	Amphetamine addiction	38/1028	91/7206	1.14362450348e-10
ko04720	Long-term potentiation	39/1028	99/7206	5.22130963445e-10
ko04740	Olfactory transduction	34/1028	80/7206	6.25650315704e-10
ko04261	Adrenergic signaling in cardiomyocytes	63/1028	205/7206	7.91743371492e-10
ko05203	Viral carcinogenesis	10/1028	277/7206	4.0069806011e-09
ko04925	Aldosterone synthesis and secretion	38/1028	105/7206	1.41685642111e-08
ko04971	Gastric acid secretion	36/1028	98/7206	2.170676945e-08
ko04060	Cytokine-cytokine receptor interaction	5/1028	191/7206	7.92505525387e-08
ko03040	Spliceosome	2/1028	145/7206	1.02172124333e-07
ko04120	Ubiquitin mediated proteolysis	2/1028	138/7206	2.25313768232e-07
ko05168	Herpes simplex infection	5/1028	182/7206	2.46731554212e-07
ko04745	Phototransduction - fly	18/1028	38/7206	1.02593505882e-06
ko05164	Influenza A	5/1028	167/7206	1.60949813046e-06
ko04964	Proximal tubule bicarbonate reclamation	15/1028	29/7206	2.03117294198e-06
ko04966	Collecting duct acid secretion	14/1028	26/7206	2.39430071369e-06
ko04976	Bile secretion	28/1028	80/7206	2.46365953111e-06
ko05322	Systemic lupus erythematosus	4/1028	151/7206	2.67515432458e-06
ko05030	Cocaine addiction	26/1028	73/7206	3.87304998658e-06
ko05162	Measles	2/1028	120/7206	4.03781708185e-06
ko05169	Epstein-Barr virus infection	9/1028	206/7206	6.22868444722e-06
ko04022	cGMP-PKG signaling pathway	55/1028	216/7206	1.05002348787e-05
ko04972	Pancreatic secretion	33/1028	111/7206	2.46804131382e-05
ko04621	NOD-like receptor signaling pathway	6/1028	157/7206	2.48526780642e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1028	74/7206	2.78017846809e-05
ko04110	Cell cycle	5/1028	145/7206	3.19674436749e-05
ko05166	HTLV-I infection	19/1028	292/7206	3.56942284267e-05
ko03013	RNA transport	7/1028	166/7206	4.02467197591e-05
ko04626	Plant-pathogen interaction	10/1028	18/7206	4.91449226633e-05
ko04730	Long-term depression	25/1028	78/7206	5.29745871191e-05
ko05161	Hepatitis B	8/1028	173/7206	5.98097332154e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1028	79/7206	6.48433860099e-05
ko04260	Cardiac muscle contraction	29/1028	98/7206	0.000102268933548
ko04514	Cell adhesion molecules (CAMs)	35/1028	130/7206	0.000120885151551
ko04924	Renin secretion	26/1028	86/7206	0.000127070152898
ko05110	Vibrio cholerae infection	21/1028	63/7206	0.000158697677842
ko04550	Signaling pathways regulating pluripotency of stem cells	8/1028	165/7206	0.000165112916189
ko04750	Inflammatory mediator regulation of TRP channels	33/1028	122/7206	0.000196906371938
ko04978	Mineral absorption	15/1028	40/7206	0.000225856926371
ko05215	Prostate cancer	4/1028	111/7206	0.000323811467595
ko04540	Gap junction	33/1028	128/7206	0.000491030977003
ko04630	Jak-STAT signaling pathway	6/1028	132/7206	0.000577246798434
ko03008	Ribosome biogenesis in eukaryotes	2/1028	79/7206	0.000957351191626
ko05205	Proteoglycans in cancer	21/1028	271/7206	0.00101728739544
ko04010	MAPK signaling pathway	67/1028	321/7206	0.00102809264068
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1028	59/7206	0.00113422745373
ko04141	Protein processing in endoplasmic reticulum	12/1028	184/7206	0.00127436053683
ko05140	Leishmaniasis	2/1028	75/7206	0.00138175896392
ko04140	Autophagy - animal	10/1028	164/7206	0.00142463120209
ko04330	Notch signaling pathway	1/1028	62/7206	0.00148901973147
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1028	182/7206	0.00170603910413
ko04214	Apoptosis - fly	2/1028	72/7206	0.00202198550527
ko04064	NF-kappa B signaling pathway	4/1028	96/7206	0.00282118912595
ko04922	Glucagon signaling pathway	31/1028	128/7206	0.00299306092379
ko00010	Glycolysis / Gluconeogenesis	20/1028	74/7206	0.00380371670709
ko04350	TGF-beta signaling pathway	5/1028	103/7206	0.00403611231194
ko04371	Apelin signaling pathway	39/1028	177/7206	0.00445373926698
ko04612	Antigen processing and presentation	3/1028	77/7206	0.00496825679119
ko04668	TNF signaling pathway	7/1028	120/7206	0.00533808611056
ko04115	p53 signaling pathway	3/1028	74/7206	0.00707906928228
ko05220	Chronic myeloid leukemia	4/1028	85/7206	0.00749003301837
ko04915	Estrogen signaling pathway	30/1028	131/7206	0.00755384118055
ko04657	IL-17 signaling pathway	4/1028	87/7206	0.0078000662927
ko04933	AGE-RAGE signaling pathway in diabetic complications	9/1028	135/7206	0.00863707537266
ko05414	Dilated cardiomyopathy	26/1028	112/7206	0.00936568394792
ko04210	Apoptosis	14/1028	180/7206	0.00937195147536
ko00290	Valine, leucine and isoleucine biosynthesis	3/1028	4/7206	0.0103479299406
ko05202	Transcriptional misregulation in cancer	15/1028	188/7206	0.0108618174339
ko05219	Bladder cancer	1/1028	48/7206	0.0111097747829
ko04974	Protein digestion and absorption	23/1028	96/7206	0.0114655175276
ko05200	Pathways in cancer	52/1028	492/7206	0.0134852387124
ko05217	Basal cell carcinoma	3/1028	68/7206	0.0142365797849
ko04113	Meiosis - yeast	3/1028	70/7206	0.0146674699657
ko05144	Malaria	1/1028	45/7206	0.0164207183065
ko03420	Nucleotide excision repair	1/1028	46/7206	0.0171655091485
ko04510	Focal adhesion	22/1028	240/7206	0.0189296941214
ko00520	Amino sugar and nucleotide sugar metabolism	2/1028	55/7206	0.0189629094112
ko05321	Inflammatory bowel disease (IBD)	2/1028	56/7206	0.0193399081178
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1028	100/7206	0.0199169916585
ko01524	Platinum drug resistance	4/1028	76/7206	0.0202130942179
ko05206	MicroRNAs in cancer	15/1028	177/7206	0.0223502790933
ko00680	Methane metabolism	10/1028	34/7206	0.0223571712179
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1028	92/7206	0.0237953505667
ko04658	Th1 and Th2 cell differentiation	6/1028	96/7206	0.0260320811657
ko04270	Vascular smooth muscle contraction	32/1028	154/7206	0.0261257893615
ko05212	Pancreatic cancer	5/1028	83/7206	0.0267816516428
ko03018	RNA degradation	5/1028	84/7206	0.0269089175135
ko04011	MAPK signaling pathway - yeast	2/1028	53/7206	0.0277380488266
ko05224	Breast cancer	15/1028	174/7206	0.0282089021959
ko04622	RIG-I-like receptor signaling pathway	3/1028	62/7206	0.0282216535937
ko04341	Hedgehog signaling pathway - fly	1/1028	38/7206	0.0351909518692
ko05418	Fluid shear stress and atherosclerosis	15/1028	173/7206	0.0357467462187
ko04014	Ras signaling pathway	52/1028	279/7206	0.0361793902502
ko00230	Purine metabolism	38/1028	194/7206	0.0370280982608
ko00240	Pyrimidine metabolism	8/1028	110/7206	0.0379744797733
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/1028	14/7206	0.0384721172876
ko04916	Melanogenesis	29/1028	142/7206	0.0391566418141
ko05145	Toxoplasmosis	10/1028	126/7206	0.0393980762565
ko01230	Biosynthesis of amino acids	19/1028	85/7206	0.0411668532787
ko00362	Benzoate degradation	3/1028	6/7206	0.0414023756643
ko00830	Retinol metabolism	11/1028	42/7206	0.0421258494056
ko04973	Carbohydrate digestion and absorption	11/1028	42/7206	0.0421258494056
ko04620	Toll-like receptor signaling pathway	7/1028	100/7206	0.0421457385485
ko00910	Nitrogen metabolism	6/1028	19/7206	0.0432215854725
ko04142	Lysosome	13/1028	151/7206	0.0451490586133
ko04360	Axon guidance	44/1028	233/7206	0.0452997031073
ko05222	Small cell lung cancer	6/1028	89/7206	0.0457351982163
ko04664	Fc epsilon RI signaling pathway	5/1028	77/7206	0.0490169584659
ko01521	EGFR tyrosine kinase inhibitor resistance	8/1028	106/7206	0.0491136843013