ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 16/121 152/7206 3.71701839884e-09 ko04930 Type II diabetes mellitus 8/121 54/7206 2.7330173058e-06 ko04728 Dopaminergic synapse 13/121 185/7206 1.20004793614e-05 ko04725 Cholinergic synapse 12/121 160/7206 1.37454262628e-05 ko04726 Serotonergic synapse 11/121 137/7206 1.68467469071e-05 ko04911 Insulin secretion 10/121 117/7206 2.40923320121e-05 ko04721 Synaptic vesicle cycle 8/121 80/7206 5.29145966064e-05 ko04727 GABAergic synapse 9/121 110/7206 8.80508288146e-05 ko04020 Calcium signaling pathway 14/121 265/7206 0.000130470934452 ko00030 Pentose phosphate pathway 5/121 32/7206 0.00017211832994 ko04024 cAMP signaling pathway 14/121 279/7206 0.000223963662114 ko04713 Circadian entrainment 9/121 136/7206 0.000440592323336 ko05032 Morphine addiction 8/121 110/7206 0.000491976123573 ko04742 Taste transduction 6/121 61/7206 0.000517187970762 ko04723 Retrograde endocannabinoid signaling 10/121 175/7206 0.000681312612858 ko04360 Axon guidance 11/121 233/7206 0.00177613656365 ko00680 Methane metabolism 4/121 34/7206 0.00237660489032 ko04010 MAPK signaling pathway 13/121 321/7206 0.00272106657801 ko00051 Fructose and mannose metabolism 4/121 42/7206 0.00517453514977 ko04720 Long-term potentiation 6/121 99/7206 0.00623040620921 ko05010 Alzheimer's disease 9/121 202/7206 0.00673617034393 ko04730 Long-term depression 5/121 78/7206 0.0097821700009 ko04972 Pancreatic secretion 6/121 111/7206 0.0107082107837 ko05230 Central carbon metabolism in cancer 5/121 81/7206 0.0114114682923 ko04964 Proximal tubule bicarbonate reclamation 3/121 29/7206 0.0122768060148 ko01230 Biosynthesis of amino acids 5/121 85/7206 0.013859304565 ko05033 Nicotine addiction 4/121 56/7206 0.0141934642224 ko04080 Neuroactive ligand-receptor interaction 14/121 423/7206 0.0164553250628 ko00052 Galactose metabolism 3/121 33/7206 0.017464801954 ko05031 Amphetamine addiction 5/121 91/7206 0.0181584240297 ko04970 Salivary secretion 5/121 95/7206 0.0214669027755 ko04921 Oxytocin signaling pathway 8/121 209/7206 0.0240411499008 ko04260 Cardiac muscle contraction 5/121 98/7206 0.0241909796254 ko04745 Phototransduction - fly 3/121 38/7206 0.0254236880286 ko02024 Quorum sensing 2/121 15/7206 0.025456560385 ko04014 Ras signaling pathway 10/121 279/7206 0.0266275119079 ko04978 Mineral absorption 3/121 40/7206 0.0290679623181 ko04960 Aldosterone-regulated sodium reabsorption 3/121 41/7206 0.0309884101966 ko04659 Th17 cell differentiation 5/121 106/7206 0.0325144609531 ko00513 Various types of N-glycan biosynthesis 3/121 42/7206 0.0329740928923 ko04973 Carbohydrate digestion and absorption 3/121 42/7206 0.0329740928923 ko01051 Biosynthesis of ansamycins 1/121 2/7206 0.0333034600094 ko05030 Cocaine addiction 4/121 73/7206 0.0338967622277 ko04710 Circadian rhythm 3/121 43/7206 0.0350247177237 ko00010 Glycolysis / Gluconeogenesis 4/121 74/7206 0.0353840455475 ko04012 ErbB signaling pathway 5/121 109/7206 0.036045136118 ko05167 Kaposi's sarcoma-associated herpesvirus infection 7/121 191/7206 0.0413648900248 ko04740 Olfactory transduction 4/121 80/7206 0.0450948325433 ko04072 Phospholipase D signaling pathway 7/121 197/7206 0.0475310070473