ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	137/844	423/7206	8.84341079683e-32
ko04724	Glutamatergic synapse	71/844	152/7206	1.3793590311e-27
ko05033	Nicotine addiction	40/844	56/7206	1.58095600006e-25
ko04721	Synaptic vesicle cycle	47/844	80/7206	3.73196374006e-24
ko04728	Dopaminergic synapse	72/844	185/7206	4.43192678601e-22
ko05032	Morphine addiction	52/844	110/7206	9.37848497346e-21
ko04713	Circadian entrainment	58/844	136/7206	2.87249511744e-20
ko04727	GABAergic synapse	50/844	110/7206	4.48885777642e-19
ko04723	Retrograde endocannabinoid signaling	64/844	175/7206	4.30881356914e-18
ko04725	Cholinergic synapse	60/844	160/7206	1.23243974566e-17
ko04024	cAMP signaling pathway	78/844	279/7206	5.11115772933e-14
ko04911	Insulin secretion	45/844	117/7206	5.50383325904e-14
ko05031	Amphetamine addiction	37/844	91/7206	1.36707778988e-12
ko04020	Calcium signaling pathway	72/844	265/7206	1.81360898713e-12
ko04744	Phototransduction	22/844	36/7206	1.90302642691e-12
ko04726	Serotonergic synapse	47/844	137/7206	2.05746813015e-12
ko04921	Oxytocin signaling pathway	58/844	209/7206	1.15045719066e-10
ko04720	Long-term potentiation	36/844	99/7206	1.26461711417e-10
ko04742	Taste transduction	26/844	61/7206	9.04720995479e-10
ko04261	Adrenergic signaling in cardiomyocytes	54/844	205/7206	6.26305550835e-09
ko05030	Cocaine addiction	27/844	73/7206	1.75889617889e-08
ko04966	Collecting duct acid secretion	15/844	26/7206	2.11022938986e-08
ko04970	Salivary secretion	30/844	95/7206	1.7903879722e-07
ko03040	Spliceosome	1/844	145/7206	5.75254803608e-07
ko04925	Aldosterone synthesis and secretion	31/844	105/7206	6.0034077152e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	24/844	74/7206	1.77892265631e-06
ko05164	Influenza A	3/844	167/7206	2.42318670323e-06
ko05168	Herpes simplex infection	4/844	182/7206	3.40273005296e-06
ko04971	Gastric acid secretion	28/844	98/7206	4.28161186855e-06
ko05110	Vibrio cholerae infection	21/844	63/7206	4.80781409503e-06
ko05162	Measles	1/844	120/7206	9.46641692345e-06
ko04745	Phototransduction - fly	15/844	38/7206	1.08141454687e-05
ko04972	Pancreatic secretion	29/844	111/7206	2.05119759534e-05
ko04070	Phosphatidylinositol signaling system	29/844	112/7206	3.61249486633e-05
ko05203	Viral carcinogenesis	13/844	277/7206	5.56078331375e-05
ko05322	Systemic lupus erythematosus	4/844	151/7206	9.36699500905e-05
ko04010	MAPK signaling pathway	61/844	321/7206	0.000117069516663
ko04740	Olfactory transduction	22/844	80/7206	0.000129597636411
ko04730	Long-term depression	21/844	78/7206	0.000227731836328
ko04141	Protein processing in endoplasmic reticulum	7/844	184/7206	0.000262502223555
ko03013	RNA transport	6/844	166/7206	0.000337220415569
ko04060	Cytokine-cytokine receptor interaction	8/844	191/7206	0.000364226317268
ko05166	HTLV-I infection	16/844	292/7206	0.00037240994528
ko04120	Ubiquitin mediated proteolysis	4/844	138/7206	0.000402036592861
ko04510	Focal adhesion	12/844	240/7206	0.000463770655981
ko04626	Plant-pathogen interaction	8/844	18/7206	0.000509771471486
ko04110	Cell cycle	5/844	145/7206	0.00060882579544
ko05205	Proteoglycans in cancer	15/844	271/7206	0.000686665683637
ko04621	NOD-like receptor signaling pathway	6/844	157/7206	0.000938468013193
ko04612	Antigen processing and presentation	1/844	77/7206	0.00114005274641
ko04964	Proximal tubule bicarbonate reclamation	10/844	29/7206	0.00114103080708
ko04610	Complement and coagulation cascades	1/844	79/7206	0.00116697906547
ko04260	Cardiac muscle contraction	23/844	98/7206	0.00120486229478
ko04514	Cell adhesion molecules (CAMs)	28/844	130/7206	0.00129694925459
ko04022	cGMP-PKG signaling pathway	41/844	216/7206	0.00166986963214
ko05034	Alcoholism	44/844	238/7206	0.00194430169106
ko04540	Gap junction	27/844	128/7206	0.00201904641936
ko04924	Renin secretion	20/844	86/7206	0.00207887960498
ko04630	Jak-STAT signaling pathway	5/844	132/7206	0.00234254516905
ko04750	Inflammatory mediator regulation of TRP channels	26/844	122/7206	0.00244219270866
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/844	92/7206	0.00268103987985
ko05169	Epstein-Barr virus infection	11/844	206/7206	0.0027588567017
ko04072	Phospholipase D signaling pathway	37/844	197/7206	0.00325675999852
ko05215	Prostate cancer	4/844	111/7206	0.00428635423126
ko05161	Hepatitis B	9/844	173/7206	0.00548673970273
ko05200	Pathways in cancer	39/844	492/7206	0.00569804860212
ko04915	Estrogen signaling pathway	26/844	131/7206	0.00581449046221
ko04210	Apoptosis	10/844	180/7206	0.00667839222206
ko03008	Ribosome biogenesis in eukaryotes	2/844	79/7206	0.00718973910815
ko05323	Rheumatoid arthritis	19/844	89/7206	0.00758074855631
ko04330	Notch signaling pathway	1/844	62/7206	0.00835878499182
ko05140	Leishmaniasis	2/844	75/7206	0.0102150834727
ko04371	Apelin signaling pathway	32/844	177/7206	0.0122846402932
ko04976	Bile secretion	17/844	80/7206	0.0130943580044
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/844	182/7206	0.0137526337016
ko04214	Apoptosis - fly	2/844	72/7206	0.0148396255544
ko05211	Renal cell carcinoma	4/844	96/7206	0.0159214692499
ko04064	NF-kappa B signaling pathway	4/844	96/7206	0.0159214692499
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/844	14/7206	0.0176266631636
ko04218	Cellular senescence	11/844	177/7206	0.0177582794985
ko05206	MicroRNAs in cancer	11/844	177/7206	0.0177582794985
ko04550	Signaling pathways regulating pluripotency of stem cells	10/844	165/7206	0.0195527927236
ko05202	Transcriptional misregulation in cancer	12/844	188/7206	0.0208229597365
ko05217	Basal cell carcinoma	2/844	68/7206	0.0209777571534
ko04014	Ras signaling pathway	45/844	279/7206	0.0225815350182
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/844	59/7206	0.0225973636717
ko05414	Dilated cardiomyopathy	21/844	112/7206	0.0256205020223
ko04611	Platelet activation	10/844	163/7206	0.0256235031913
ko05222	Small cell lung cancer	4/844	89/7206	0.0301002305872
ko01524	Platinum drug resistance	3/844	76/7206	0.0304453615838
ko04810	Regulation of actin cytoskeleton	20/844	264/7206	0.0317330279951
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	16/844	79/7206	0.032148643737
ko00190	Oxidative phosphorylation	23/844	127/7206	0.0351657591959
ko03420	Nucleotide excision repair	1/844	46/7206	0.0377759577215
ko05219	Bladder cancer	1/844	48/7206	0.0388691960508
ko05220	Chronic myeloid leukemia	4/844	85/7206	0.0410446873054
ko05224	Breast cancer	12/844	174/7206	0.0426650892357
ko04115	p53 signaling pathway	3/844	74/7206	0.0430842093658
ko04668	TNF signaling pathway	7/844	120/7206	0.0440941368027
ko01521	EGFR tyrosine kinase inhibitor resistance	6/844	106/7206	0.0480970400431