ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 16/173 79/7206 3.52250657787e-11 ko01200 Carbon metabolism 19/173 128/7206 1.4304224502e-10 ko00010 Glycolysis / Gluconeogenesis 12/173 74/7206 1.50676156256e-07 ko00620 Pyruvate metabolism 9/173 46/7206 1.10436893404e-06 ko01230 Biosynthesis of amino acids 11/173 85/7206 5.08007473203e-06 ko00680 Methane metabolism 7/173 34/7206 1.26694563993e-05 ko00380 Tryptophan metabolism 8/173 50/7206 2.13160184851e-05 ko00630 Glyoxylate and dicarboxylate metabolism 7/173 38/7206 2.74090293089e-05 ko00280 Valine, leucine and isoleucine degradation 8/173 54/7206 3.80665639087e-05 ko00643 Styrene degradation 3/173 4/7206 5.345304192e-05 ko00830 Retinol metabolism 7/173 42/7206 5.40374162233e-05 ko00071 Fatty acid degradation 7/173 45/7206 8.55469658552e-05 ko00260 Glycine, serine and threonine metabolism 7/173 48/7206 0.000130640549552 ko00020 Citrate cycle (TCA cycle) 6/173 35/7206 0.000159786554067 ko05012 Parkinson's disease 12/173 155/7206 0.000329543267658 ko00983 Drug metabolism - other enzymes 6/173 42/7206 0.000449360209222 ko00030 Pentose phosphate pathway 5/173 32/7206 0.000895874281338 ko00190 Oxidative phosphorylation 10/173 127/7206 0.000909641429155 ko05204 Chemical carcinogenesis 6/173 48/7206 0.000933344550495 ko04922 Glucagon signaling pathway 10/173 128/7206 0.000966622871328 ko00350 Tyrosine metabolism 5/173 33/7206 0.00103559155338 ko00640 Propanoate metabolism 5/173 34/7206 0.00119085647493 ko05150 Staphylococcus aureus infection 5/173 36/7206 0.00155217458825 ko04974 Protein digestion and absorption 8/173 96/7206 0.00206404734175 ko05410 Hypertrophic cardiomyopathy (HCM) 8/173 100/7206 0.00267134148497 ko00340 Histidine metabolism 4/173 25/7206 0.00273583144717 ko01212 Fatty acid metabolism 6/173 60/7206 0.00300439004689 ko05010 Alzheimer's disease 12/173 202/7206 0.00330898600798 ko00710 Carbon fixation in photosynthetic organisms 4/173 27/7206 0.00365656018526 ko04146 Peroxisome 7/173 89/7206 0.00536916348822 ko04920 Adipocytokine signaling pathway 7/173 89/7206 0.00536916348822 ko05016 Huntington's disease 12/173 215/7206 0.00545586013878 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/173 5/7206 0.0054639144577 ko00281 Geraniol degradation 2/173 5/7206 0.0054639144577 ko04611 Platelet activation 10/173 163/7206 0.00571825653584 ko03320 PPAR signaling pathway 6/173 69/7206 0.00602732163801 ko00720 Carbon fixation pathways in prokaryotes 3/173 17/7206 0.00721742021719 ko00360 Phenylalanine metabolism 3/173 17/7206 0.00721742021719 ko04614 Renin-angiotensin system 3/173 18/7206 0.00851001508122 ko04260 Cardiac muscle contraction 7/173 98/7206 0.00901191455828 ko00500 Starch and sucrose metabolism 4/173 35/7206 0.00940241619584 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6/173 79/7206 0.0114907921006 ko00250 Alanine, aspartate and glutamate metabolism 4/173 38/7206 0.012539621382 ko00980 Metabolism of xenobiotics by cytochrome P450 4/173 40/7206 0.0149625407821 ko00053 Ascorbate and aldarate metabolism 3/173 22/7206 0.0149734193777 ko00140 Steroid hormone biosynthesis 4/173 41/7206 0.0162772518293 ko04144 Endocytosis 2/173 342/7206 0.0175865788999 ko00051 Fructose and mannose metabolism 4/173 42/7206 0.0176622977687 ko05133 Pertussis 6/173 87/7206 0.0178610345504 ko04022 cGMP-PKG signaling pathway 11/173 216/7206 0.0195092202526 ko04910 Insulin signaling pathway 9/173 172/7206 0.0224022559932 ko00072 Synthesis and degradation of ketone bodies 2/173 10/7206 0.0227203317692 ko00040 Pentose and glucuronate interconversions 3/173 26/7206 0.0235766730217 ko00650 Butanoate metabolism 3/173 26/7206 0.0235766730217 ko00401 Novobiocin biosynthesis 1/173 1/7206 0.0240077713018 ko00270 Cysteine and methionine metabolism 4/173 47/7206 0.0256753271697 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 2/173 11/7206 0.0273366497551 ko04270 Vascular smooth muscle contraction 8/173 154/7206 0.0316626179581 ko00520 Amino sugar and nucleotide sugar metabolism 4/173 55/7206 0.0424196296908 ko00062 Fatty acid elongation 3/173 33/7206 0.0438268611812 ko00052 Galactose metabolism 3/173 33/7206 0.0438268611812 ko04931 Insulin resistance 7/173 137/7206 0.0464209736544 ko00300 Lysine biosynthesis 1/173 2/7206 0.0474424216231 ko00254 Aflatoxin biosynthesis 1/173 2/7206 0.0474424216231 ko05034 Alcoholism 1/173 238/7206 0.0475336128542