ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1229	423/7206	2.44076920847e-53
ko04724	Glutamatergic synapse	91/1229	152/7206	3.66915179126e-33
ko05033	Nicotine addiction	49/1229	56/7206	6.92456604034e-31
ko04727	GABAergic synapse	71/1229	110/7206	5.22810647209e-29
ko05032	Morphine addiction	71/1229	110/7206	5.22810647209e-29
ko04713	Circadian entrainment	77/1229	136/7206	5.83057759414e-26
ko04728	Dopaminergic synapse	86/1229	185/7206	4.22809732969e-21
ko04723	Retrograde endocannabinoid signaling	82/1229	175/7206	1.94461657515e-20
ko04725	Cholinergic synapse	77/1229	160/7206	3.94699986044e-20
ko04721	Synaptic vesicle cycle	50/1229	80/7206	7.56265587046e-20
ko04726	Serotonergic synapse	66/1229	137/7206	1.9225291009e-17
ko04742	Taste transduction	40/1229	61/7206	3.2925101396e-17
ko04911	Insulin secretion	59/1229	117/7206	6.64473833891e-17
ko04020	Calcium signaling pathway	100/1229	265/7206	2.3701176184e-16
ko04744	Phototransduction	28/1229	36/7206	1.77493361065e-15
ko04024	cAMP signaling pathway	100/1229	279/7206	1.38924948189e-14
ko04921	Oxytocin signaling pathway	79/1229	209/7206	3.76533465474e-13
ko04740	Olfactory transduction	41/1229	80/7206	1.95887901541e-12
ko05031	Amphetamine addiction	42/1229	91/7206	8.37864541601e-11
ko04970	Salivary secretion	43/1229	95/7206	1.09537132772e-10
ko04720	Long-term potentiation	44/1229	99/7206	1.39330036998e-10
ko03040	Spliceosome	2/1229	145/7206	9.64848525924e-10
ko04261	Adrenergic signaling in cardiomyocytes	70/1229	205/7206	2.13493695264e-09
ko04925	Aldosterone synthesis and secretion	42/1229	105/7206	1.99059087761e-08
ko05168	Herpes simplex infection	7/1229	182/7206	6.28816354609e-08
ko04971	Gastric acid secretion	39/1229	98/7206	7.59490408347e-08
ko04966	Collecting duct acid secretion	16/1229	26/7206	4.47467107559e-07
ko03013	RNA transport	7/1229	166/7206	5.68612089133e-07
ko05322	Systemic lupus erythematosus	6/1229	151/7206	9.84004450933e-07
ko05203	Viral carcinogenesis	20/1229	277/7206	1.7999396293e-06
ko04621	NOD-like receptor signaling pathway	7/1229	157/7206	2.5561088176e-06
ko04745	Phototransduction - fly	19/1229	38/7206	2.95590294512e-06
ko05030	Cocaine addiction	29/1229	73/7206	4.43595843534e-06
ko04972	Pancreatic secretion	39/1229	111/7206	4.73200527156e-06
ko04514	Cell adhesion molecules (CAMs)	43/1229	130/7206	8.54558861582e-06
ko05164	Influenza A	9/1229	167/7206	8.99397441699e-06
ko04120	Ubiquitin mediated proteolysis	6/1229	138/7206	9.47141026767e-06
ko04110	Cell cycle	7/1229	145/7206	1.05109409362e-05
ko04360	Axon guidance	66/1229	233/7206	1.21734453595e-05
ko04060	Cytokine-cytokine receptor interaction	12/1229	191/7206	1.39651242396e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1229	74/7206	1.56236545664e-05
ko04730	Long-term depression	28/1229	78/7206	5.2685440372e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1229	79/7206	6.51587546144e-05
ko04022	cGMP-PKG signaling pathway	60/1229	216/7206	6.68302057336e-05
ko04540	Gap junction	40/1229	128/7206	6.97617106436e-05
ko04010	MAPK signaling pathway	82/1229	321/7206	9.76209955529e-05
ko04070	Phosphatidylinositol signaling system	36/1229	112/7206	0.000107678928633
ko03008	Ribosome biogenesis in eukaryotes	2/1229	79/7206	0.000112110584863
ko04612	Antigen processing and presentation	2/1229	77/7206	0.000172134426976
ko04141	Protein processing in endoplasmic reticulum	14/1229	184/7206	0.000220639984548
ko04750	Inflammatory mediator regulation of TRP channels	37/1229	122/7206	0.000236039117942
ko04976	Bile secretion	27/1229	80/7206	0.000249692669498
ko05110	Vibrio cholerae infection	23/1229	63/7206	0.000261003633676
ko05162	Measles	7/1229	120/7206	0.000342936331828
ko04260	Cardiac muscle contraction	31/1229	98/7206	0.00035356105088
ko04610	Complement and coagulation cascades	3/1229	79/7206	0.000465015366325
ko04072	Phospholipase D signaling pathway	53/1229	197/7206	0.000487534906866
ko04146	Peroxisome	4/1229	89/7206	0.00054931369945
ko05169	Epstein-Barr virus infection	18/1229	206/7206	0.000682476258693
ko04064	NF-kappa B signaling pathway	5/1229	96/7206	0.000876613028018
ko05414	Dilated cardiomyopathy	33/1229	112/7206	0.000918258541678
ko05205	Proteoglycans in cancer	27/1229	271/7206	0.000962483894777
ko05140	Leishmaniasis	3/1229	75/7206	0.000989010089625
ko00590	Arachidonic acid metabolism	1/1229	52/7206	0.00125357138092
ko04964	Proximal tubule bicarbonate reclamation	12/1229	29/7206	0.00172437106274
ko05161	Hepatitis B	15/1229	173/7206	0.00201680976596
ko05166	HTLV-I infection	31/1229	292/7206	0.00243459619524
ko04014	Ras signaling pathway	67/1229	279/7206	0.00256356204238
ko03420	Nucleotide excision repair	1/1229	46/7206	0.00283190495895
ko05016	Huntington's disease	21/1229	215/7206	0.00307457246135
ko04930	Type II diabetes mellitus	18/1229	54/7206	0.00313332251329
ko05145	Toxoplasmosis	10/1229	126/7206	0.00398347872136
ko03022	Basal transcription factors	1/1229	44/7206	0.00425794190789
ko05144	Malaria	1/1229	45/7206	0.00435733853436
ko00071	Fatty acid degradation	1/1229	45/7206	0.00435733853436
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1229	59/7206	0.00452281192107
ko00240	Pyrimidine metabolism	8/1229	110/7206	0.00454295496276
ko04270	Vascular smooth muscle contraction	40/1229	154/7206	0.00463631785453
ko00310	Lysine degradation	4/1229	73/7206	0.00468838927798
ko04915	Estrogen signaling pathway	35/1229	131/7206	0.00469046616502
ko05131	Shigellosis	5/1229	82/7206	0.0048138489153
ko04630	Jak-STAT signaling pathway	11/1229	132/7206	0.00493269763094
ko04924	Renin secretion	25/1229	86/7206	0.00552986266238
ko04626	Plant-pathogen interaction	8/1229	18/7206	0.00610600458283
ko04330	Notch signaling pathway	3/1229	62/7206	0.00624118476744
ko04622	RIG-I-like receptor signaling pathway	3/1229	62/7206	0.00624118476744
ko04371	Apelin signaling pathway	44/1229	177/7206	0.00815672969105
ko04658	Th1 and Th2 cell differentiation	7/1229	96/7206	0.00879838219871
ko04657	IL-17 signaling pathway	6/1229	87/7206	0.00916701376475
ko05133	Pertussis	6/1229	87/7206	0.00916701376475
ko05219	Bladder cancer	2/1229	48/7206	0.0117532623425
ko03018	RNA degradation	6/1229	84/7206	0.0124814396808
ko04710	Circadian rhythm	14/1229	43/7206	0.012698068305
ko04918	Thyroid hormone synthesis	24/1229	86/7206	0.0131502070122
ko04923	Regulation of lipolysis in adipocytes	22/1229	77/7206	0.0135871649333
ko00630	Glyoxylate and dicarboxylate metabolism	1/1229	38/7206	0.0149831200092
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1229	182/7206	0.0161376193149
ko04916	Melanogenesis	35/1229	142/7206	0.0179963244825
ko05321	Inflammatory bowel disease (IBD)	3/1229	56/7206	0.0186763673798
ko04960	Aldosterone-regulated sodium reabsorption	13/1229	41/7206	0.0199160144539
ko04217	Necroptosis	19/1229	178/7206	0.0201091651467
ko04912	GnRH signaling pathway	31/1229	122/7206	0.0202124291685
ko04210	Apoptosis	19/1229	180/7206	0.0204149537086
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1229	14/7206	0.0211435480111
ko05215	Prostate cancer	10/1229	111/7206	0.0215384187729
ko00860	Porphyrin and chlorophyll metabolism	1/1229	34/7206	0.021662979143
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1229	100/7206	0.0221564312236
ko04973	Carbohydrate digestion and absorption	13/1229	42/7206	0.0228102448489
ko04922	Glucagon signaling pathway	32/1229	128/7206	0.0233949336269
ko00280	Valine, leucine and isoleucine degradation	3/1229	54/7206	0.026992880487
ko05220	Chronic myeloid leukemia	7/1229	85/7206	0.02875292939
ko05418	Fluid shear stress and atherosclerosis	19/1229	173/7206	0.031325740452
ko04620	Toll-like receptor signaling pathway	9/1229	100/7206	0.031354184598
ko05200	Pathways in cancer	67/1229	492/7206	0.0348043244979
ko01212	Fatty acid metabolism	4/1229	60/7206	0.0364159876404
ko00230	Purine metabolism	44/1229	194/7206	0.0416187495999
ko04115	p53 signaling pathway	6/1229	74/7206	0.0421564484047
ko05320	Autoimmune thyroid disease	1/1229	29/7206	0.0482541585761
ko05340	Primary immunodeficiency	1/1229	30/7206	0.0486958801888
ko05202	Transcriptional misregulation in cancer	22/1229	188/7206	0.0491804398195