ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1229	423/7206	1.69685846179e-50
ko04724	Glutamatergic synapse	92/1229	152/7206	4.66004395903e-34
ko05033	Nicotine addiction	50/1229	56/7206	1.9071624596e-32
ko05032	Morphine addiction	73/1229	110/7206	5.54740784423e-31
ko04713	Circadian entrainment	80/1229	136/7206	1.67022569003e-28
ko04727	GABAergic synapse	69/1229	110/7206	4.19554370377e-27
ko04728	Dopaminergic synapse	89/1229	185/7206	4.20106030367e-23
ko04723	Retrograde endocannabinoid signaling	82/1229	175/7206	1.94461657515e-20
ko04721	Synaptic vesicle cycle	50/1229	80/7206	7.56265587046e-20
ko04725	Cholinergic synapse	76/1229	160/7206	1.86214257394e-19
ko04024	cAMP signaling pathway	109/1229	279/7206	3.64984262329e-19
ko04020	Calcium signaling pathway	97/1229	265/7206	5.98938263609e-15
ko04726	Serotonergic synapse	62/1229	137/7206	7.76577604018e-15
ko04911	Insulin secretion	56/1229	117/7206	7.93023563487e-15
ko04744	Phototransduction	27/1229	36/7206	2.76884238084e-14
ko04742	Taste transduction	36/1229	61/7206	1.53957867355e-13
ko04921	Oxytocin signaling pathway	78/1229	209/7206	9.81850871987e-13
ko05031	Amphetamine addiction	44/1229	91/7206	4.07093547394e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1229	205/7206	9.81317735201e-12
ko03040	Spliceosome	1/1229	145/7206	7.13423270132e-11
ko04720	Long-term potentiation	43/1229	99/7206	5.53968403311e-10
ko05030	Cocaine addiction	35/1229	73/7206	8.79039512471e-10
ko04970	Salivary secretion	41/1229	95/7206	1.76811978981e-09
ko05203	Viral carcinogenesis	15/1229	277/7206	4.54023025937e-09
ko04925	Aldosterone synthesis and secretion	43/1229	105/7206	7.56565870521e-09
ko04971	Gastric acid secretion	39/1229	98/7206	7.59490408347e-08
ko04060	Cytokine-cytokine receptor interaction	8/1229	191/7206	7.61456477997e-08
ko04360	Axon guidance	72/1229	233/7206	1.17068081311e-07
ko05322	Systemic lupus erythematosus	5/1229	151/7206	2.53558428973e-07
ko03013	RNA transport	7/1229	166/7206	5.68612089133e-07
ko04070	Phosphatidylinositol signaling system	41/1229	112/7206	6.56542319336e-07
ko04740	Olfactory transduction	32/1229	80/7206	1.16499114931e-06
ko04010	MAPK signaling pathway	88/1229	321/7206	2.05290173812e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1229	74/7206	2.27426392237e-06
ko04022	cGMP-PKG signaling pathway	64/1229	216/7206	3.34343646524e-06
ko05164	Influenza A	9/1229	167/7206	8.99397441699e-06
ko04610	Complement and coagulation cascades	1/1229	79/7206	1.28764143546e-05
ko04972	Pancreatic secretion	37/1229	111/7206	3.12539107321e-05
ko05168	Herpes simplex infection	12/1229	182/7206	3.659717751e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1229	59/7206	6.41780204845e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1229	79/7206	6.51587546144e-05
ko04072	Phospholipase D signaling pathway	56/1229	197/7206	6.83095975553e-05
ko04141	Protein processing in endoplasmic reticulum	13/1229	184/7206	9.25018829876e-05
ko05414	Dilated cardiomyopathy	36/1229	112/7206	0.000107678928633
ko03008	Ribosome biogenesis in eukaryotes	2/1229	79/7206	0.000112110584863
ko05205	Proteoglycans in cancer	24/1229	271/7206	0.000136573884818
ko04924	Renin secretion	29/1229	86/7206	0.00013927212479
ko04730	Long-term depression	27/1229	78/7206	0.000188981255766
ko04014	Ras signaling pathway	71/1229	279/7206	0.000325316123251
ko04540	Gap junction	38/1229	128/7206	0.000328590028116
ko05162	Measles	7/1229	120/7206	0.000342936331828
ko04621	NOD-like receptor signaling pathway	11/1229	157/7206	0.000344959062924
ko04110	Cell cycle	10/1229	145/7206	0.00047891622885
ko05110	Vibrio cholerae infection	22/1229	63/7206	0.000555770010482
ko04612	Antigen processing and presentation	3/1229	77/7206	0.000676405041491
ko05169	Epstein-Barr virus infection	18/1229	206/7206	0.000682476258693
ko04745	Phototransduction - fly	15/1229	38/7206	0.000851954863382
ko04260	Cardiac muscle contraction	30/1229	98/7206	0.000970795223984
ko05140	Leishmaniasis	3/1229	75/7206	0.000989010089625
ko04640	Hematopoietic cell lineage	2/1229	64/7206	0.00118870298145
ko00590	Arachidonic acid metabolism	1/1229	52/7206	0.00125357138092
ko00240	Pyrimidine metabolism	7/1229	110/7206	0.00129542177889
ko04514	Cell adhesion molecules (CAMs)	37/1229	130/7206	0.00130868715135
ko04915	Estrogen signaling pathway	37/1229	131/7206	0.00137323434117
ko04750	Inflammatory mediator regulation of TRP channels	35/1229	122/7206	0.00139965127513
ko04976	Bile secretion	25/1229	80/7206	0.00151666025505
ko04923	Regulation of lipolysis in adipocytes	24/1229	77/7206	0.0020339876456
ko04966	Collecting duct acid secretion	11/1229	26/7206	0.0021608449109
ko04064	NF-kappa B signaling pathway	6/1229	96/7206	0.00249262246242
ko04711	Circadian rhythm - fly	7/1229	13/7206	0.00272590115153
ko03420	Nucleotide excision repair	1/1229	46/7206	0.00283190495895
ko05321	Inflammatory bowel disease (IBD)	2/1229	56/7206	0.00375132862862
ko05161	Hepatitis B	16/1229	173/7206	0.00406646806396
ko03022	Basal transcription factors	1/1229	44/7206	0.00425794190789
ko05144	Malaria	1/1229	45/7206	0.00435733853436
ko00071	Fatty acid degradation	1/1229	45/7206	0.00435733853436
ko04371	Apelin signaling pathway	45/1229	177/7206	0.0043859675567
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1229	14/7206	0.00465596259788
ko03018	RNA degradation	5/1229	84/7206	0.00495023159786
ko00480	Glutathione metabolism	2/1229	55/7206	0.00582222294209
ko04120	Ubiquitin mediated proteolysis	12/1229	138/7206	0.00598902166334
ko05166	HTLV-I infection	33/1229	292/7206	0.0067713932988
ko04350	TGF-beta signaling pathway	8/1229	103/7206	0.00822237253537
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1229	182/7206	0.00906783236561
ko00330	Arginine and proline metabolism	3/1229	61/7206	0.00918789008747
ko03320	PPAR signaling pathway	4/1229	69/7206	0.00935565420168
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1229	40/7206	0.00980121865923
ko00562	Inositol phosphate metabolism	25/1229	89/7206	0.00982698820196
ko04912	GnRH signaling pathway	32/1229	122/7206	0.0102398807786
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1229	100/7206	0.010731066041
ko04217	Necroptosis	18/1229	178/7206	0.0113420702082
ko05219	Bladder cancer	2/1229	48/7206	0.0117532623425
ko04710	Circadian rhythm	14/1229	43/7206	0.012698068305
ko04015	Rap1 signaling pathway	63/1229	278/7206	0.0144540295993
ko00982	Drug metabolism - cytochrome P450	1/1229	37/7206	0.0144990351148
ko00290	Valine, leucine and isoleucine biosynthesis	3/1229	4/7206	0.017275915108
ko04115	p53 signaling pathway	5/1229	74/7206	0.0184012980482
ko04658	Th1 and Th2 cell differentiation	8/1229	96/7206	0.0197330428933
ko04210	Apoptosis	19/1229	180/7206	0.0204149537086
ko04140	Autophagy - animal	17/1229	164/7206	0.0204490441583
ko04918	Thyroid hormone synthesis	23/1229	86/7206	0.0207325252641
ko04657	IL-17 signaling pathway	7/1229	87/7206	0.0214274719391
ko05133	Pertussis	7/1229	87/7206	0.0214274719391
ko04146	Peroxisome	7/1229	89/7206	0.0220286224082
ko05145	Toxoplasmosis	12/1229	126/7206	0.0226069737318
ko00513	Various types of N-glycan biosynthesis	13/1229	42/7206	0.0228102448489
ko04626	Plant-pathogen interaction	7/1229	18/7206	0.0230975561847
ko04622	RIG-I-like receptor signaling pathway	4/1229	62/7206	0.025888101543
ko04630	Jak-STAT signaling pathway	13/1229	132/7206	0.025916790347
ko00280	Valine, leucine and isoleucine degradation	3/1229	54/7206	0.026992880487
ko00515	Mannose type O-glycan biosynthesis	9/1229	25/7206	0.0272077984133
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1229	15/7206	0.0302661284087
ko04620	Toll-like receptor signaling pathway	9/1229	100/7206	0.031354184598
ko05016	Huntington's disease	25/1229	215/7206	0.0337514483628
ko04071	Sphingolipid signaling pathway	38/1229	162/7206	0.0341434317777
ko05231	Choline metabolism in cancer	32/1229	134/7206	0.037193705619
ko05131	Shigellosis	7/1229	82/7206	0.0382317702841
ko04270	Vascular smooth muscle contraction	36/1229	154/7206	0.039486268261
ko00230	Purine metabolism	44/1229	194/7206	0.0416187495999
ko00310	Lysine degradation	6/1229	73/7206	0.0419249157006
ko05215	Prostate cancer	11/1229	111/7206	0.0419514843017
ko04218	Cellular senescence	20/1229	177/7206	0.042399850004
ko04930	Type II diabetes mellitus	15/1229	54/7206	0.0444961190514
ko04062	Chemokine signaling pathway	45/1229	201/7206	0.0456867236067
ko05202	Transcriptional misregulation in cancer	22/1229	188/7206	0.0491804398195