ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	176/1091	423/7206	2.19177993418e-42
ko04724	Glutamatergic synapse	87/1091	152/7206	9.75499831287e-34
ko05033	Nicotine addiction	48/1091	56/7206	7.51497660051e-32
ko04727	GABAergic synapse	66/1091	110/7206	1.84950743578e-27
ko05032	Morphine addiction	66/1091	110/7206	1.84950743578e-27
ko04713	Circadian entrainment	72/1091	136/7206	3.31823375069e-25
ko04728	Dopaminergic synapse	82/1091	185/7206	5.93477624174e-22
ko04725	Cholinergic synapse	74/1091	160/7206	2.96287248445e-21
ko04721	Synaptic vesicle cycle	49/1091	80/7206	3.18449524069e-21
ko04723	Retrograde endocannabinoid signaling	76/1091	175/7206	9.10804540099e-20
ko04024	cAMP signaling pathway	99/1091	279/7206	7.81197248283e-18
ko04744	Phototransduction	27/1091	36/7206	1.30332696934e-15
ko04742	Taste transduction	35/1091	61/7206	2.76768702363e-14
ko04911	Insulin secretion	50/1091	117/7206	4.48550210558e-13
ko04020	Calcium signaling pathway	86/1091	265/7206	5.94502745455e-13
ko04726	Serotonergic synapse	54/1091	137/7206	2.6418586217e-12
ko04921	Oxytocin signaling pathway	71/1091	209/7206	5.439303156e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1091	205/7206	1.70848193774e-11
ko05031	Amphetamine addiction	40/1091	91/7206	3.50347416125e-11
ko04720	Long-term potentiation	42/1091	99/7206	4.57761682864e-11
ko03040	Spliceosome	1/1091	145/7206	2.31713764692e-09
ko05203	Viral carcinogenesis	12/1091	277/7206	9.58742744439e-09
ko04970	Salivary secretion	37/1091	95/7206	1.12163648955e-08
ko04740	Olfactory transduction	31/1091	80/7206	1.99094023113e-07
ko05030	Cocaine addiction	29/1091	73/7206	2.63303191555e-07
ko04925	Aldosterone synthesis and secretion	36/1091	105/7206	7.73589424512e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1091	74/7206	1.36375899332e-06
ko05168	Herpes simplex infection	7/1091	182/7206	1.55153310672e-06
ko04360	Axon guidance	63/1091	233/7206	1.68528416235e-06
ko04060	Cytokine-cytokine receptor interaction	8/1091	191/7206	1.73185618703e-06
ko04745	Phototransduction - fly	18/1091	38/7206	2.49505409443e-06
ko04022	cGMP-PKG signaling pathway	59/1091	216/7206	2.74970713559e-06
ko04120	Ubiquitin mediated proteolysis	4/1091	138/7206	3.4368507199e-06
ko04971	Gastric acid secretion	33/1091	98/7206	5.09493817082e-06
ko04514	Cell adhesion molecules (CAMs)	40/1091	130/7206	5.32034165699e-06
ko03013	RNA transport	7/1091	166/7206	8.97889004529e-06
ko05164	Influenza A	7/1091	167/7206	9.0154998538e-06
ko04141	Protein processing in endoplasmic reticulum	9/1091	184/7206	1.5172670177e-05
ko05322	Systemic lupus erythematosus	6/1091	151/7206	1.60310846949e-05
ko04966	Collecting duct acid secretion	13/1091	26/7206	3.09339558421e-05
ko04621	NOD-like receptor signaling pathway	7/1091	157/7206	3.78458353762e-05
ko05169	Epstein-Barr virus infection	12/1091	206/7206	4.35748307919e-05
ko04730	Long-term depression	26/1091	78/7206	4.7025397817e-05
ko04072	Phospholipase D signaling pathway	51/1091	197/7206	7.06935811985e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1091	79/7206	8.98883066813e-05
ko04924	Renin secretion	27/1091	86/7206	0.000114561122551
ko04010	MAPK signaling pathway	73/1091	321/7206	0.000228475998585
ko04972	Pancreatic secretion	32/1091	111/7206	0.000237050550078
ko04064	NF-kappa B signaling pathway	3/1091	96/7206	0.000255133619848
ko04070	Phosphatidylinositol signaling system	32/1091	112/7206	0.000257467119569
ko04260	Cardiac muscle contraction	29/1091	98/7206	0.000285959106894
ko04110	Cell cycle	8/1091	145/7206	0.000402440756098
ko04610	Complement and coagulation cascades	2/1091	79/7206	0.000410319286428
ko03008	Ribosome biogenesis in eukaryotes	2/1091	79/7206	0.000410319286428
ko05161	Hepatitis B	11/1091	173/7206	0.000527535336675
ko05205	Proteoglycans in cancer	22/1091	271/7206	0.000527579042088
ko04626	Plant-pathogen interaction	9/1091	18/7206	0.000538682244434
ko04540	Gap junction	34/1091	128/7206	0.00068753582043
ko05414	Dilated cardiomyopathy	31/1091	112/7206	0.000732721333077
ko05162	Measles	6/1091	120/7206	0.000737057714808
ko05140	Leishmaniasis	2/1091	75/7206	0.000922311370132
ko05110	Vibrio cholerae infection	20/1091	63/7206	0.00105661441881
ko04014	Ras signaling pathway	62/1091	279/7206	0.00152646106906
ko00480	Glutathione metabolism	1/1091	55/7206	0.00208891958471
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1091	14/7206	0.00230760021626
ko04146	Peroxisome	4/1091	89/7206	0.00258133892804
ko00240	Pyrimidine metabolism	6/1091	110/7206	0.00282513561416
ko04915	Estrogen signaling pathway	33/1091	131/7206	0.00282820353726
ko00590	Arachidonic acid metabolism	1/1091	52/7206	0.00312909690987
ko05166	HTLV-I infection	27/1091	292/7206	0.00339908556462
ko04612	Antigen processing and presentation	3/1091	77/7206	0.00341946845462
ko04976	Bile secretion	22/1091	80/7206	0.00414380914427
ko03018	RNA degradation	4/1091	84/7206	0.00521079071268
ko04923	Regulation of lipolysis in adipocytes	21/1091	77/7206	0.00579036018873
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1091	182/7206	0.0063438672005
ko04214	Apoptosis - fly	3/1091	72/7206	0.00715019274666
ko00562	Inositol phosphate metabolism	23/1091	89/7206	0.007165033361
ko04964	Proximal tubule bicarbonate reclamation	10/1091	29/7206	0.00780260072111
ko03022	Basal transcription factors	1/1091	44/7206	0.0104430804147
ko04750	Inflammatory mediator regulation of TRP channels	29/1091	122/7206	0.0104871351979
ko05144	Malaria	1/1091	45/7206	0.0106264706608
ko00071	Fatty acid degradation	1/1091	45/7206	0.0106264706608
ko03420	Nucleotide excision repair	1/1091	46/7206	0.011126315727
ko05034	Alcoholism	50/1091	238/7206	0.0128657670396
ko05321	Inflammatory bowel disease (IBD)	2/1091	56/7206	0.0131907004863
ko04630	Jak-STAT signaling pathway	10/1091	132/7206	0.013559264607
ko01524	Platinum drug resistance	4/1091	76/7206	0.0144921237655
ko04210	Apoptosis	16/1091	180/7206	0.0152793134448
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1091	59/7206	0.0162418560375
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1091	15/7206	0.0174533408912
ko05131	Shigellosis	5/1091	82/7206	0.0191693249697
ko00330	Arginine and proline metabolism	3/1091	61/7206	0.0195152679559
ko04330	Notch signaling pathway	3/1091	62/7206	0.0195623835996
ko04622	RIG-I-like receptor signaling pathway	3/1091	62/7206	0.0195623835996
ko04510	Focal adhesion	24/1091	240/7206	0.0219324963702
ko05145	Toxoplasmosis	10/1091	126/7206	0.0231346144186
ko00630	Glyoxylate and dicarboxylate metabolism	1/1091	38/7206	0.023172301221
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1091	40/7206	0.0239099316363
ko04371	Apelin signaling pathway	38/1091	177/7206	0.0250383350806
ko03320	PPAR signaling pathway	4/1091	69/7206	0.0272152844501
ko04062	Chemokine signaling pathway	42/1091	201/7206	0.0275092162837
ko04658	Th1 and Th2 cell differentiation	7/1091	96/7206	0.030553583729
ko05418	Fluid shear stress and atherosclerosis	16/1091	173/7206	0.0310164038324
ko04657	IL-17 signaling pathway	6/1091	87/7206	0.0335793078132
ko05133	Pertussis	6/1091	87/7206	0.0335793078132
ko04722	Neurotrophin signaling pathway	34/1091	160/7206	0.0338567265391
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1091	100/7206	0.0342662755105
ko04930	Type II diabetes mellitus	14/1091	54/7206	0.0347584716219
ko00982	Drug metabolism - cytochrome P450	1/1091	37/7206	0.0350930853561
ko04668	TNF signaling pathway	10/1091	120/7206	0.0388204867526
ko00260	Glycine, serine and threonine metabolism	2/1091	48/7206	0.0398942993206
ko04912	GnRH signaling pathway	27/1091	122/7206	0.0402924378025
ko05016	Huntington's disease	22/1091	215/7206	0.042203104125
ko00310	Lysine degradation	5/1091	73/7206	0.0480079907348
ko04115	p53 signaling pathway	5/1091	74/7206	0.0485582003981