ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 24/250 152/7206 3.2536524603e-10 ko05033 Nicotine addiction 13/250 56/7206 3.86159719777e-08 ko04725 Cholinergic synapse 20/250 160/7206 5.58143815067e-07 ko04727 GABAergic synapse 16/250 110/7206 1.02729523854e-06 ko05032 Morphine addiction 16/250 110/7206 1.02729523854e-06 ko04723 Retrograde endocannabinoid signaling 20/250 175/7206 2.3450320965e-06 ko04911 Insulin secretion 15/250 117/7206 1.11102423757e-05 ko04072 Phospholipase D signaling pathway 20/250 197/7206 1.43770151106e-05 ko04721 Synaptic vesicle cycle 12/250 80/7206 1.72561681124e-05 ko04080 Neuroactive ligand-receptor interaction 31/250 423/7206 8.48489983895e-05 ko04010 MAPK signaling pathway 25/250 321/7206 0.000125183678653 ko04728 Dopaminergic synapse 17/250 185/7206 0.000219788250624 ko04726 Serotonergic synapse 14/250 137/7206 0.000266328959433 ko04710 Circadian rhythm 7/250 43/7206 0.000615052998437 ko04015 Rap1 signaling pathway 21/250 278/7206 0.00066599224894 ko04024 cAMP signaling pathway 21/250 279/7206 0.000694327213656 ko04713 Circadian entrainment 13/250 136/7206 0.000834647685015 ko04742 Taste transduction 8/250 61/7206 0.00112390633115 ko04730 Long-term depression 9/250 78/7206 0.00141999348008 ko04070 Phosphatidylinositol signaling system 11/250 112/7206 0.00166607756038 ko04930 Type II diabetes mellitus 7/250 54/7206 0.0024447729423 ko04925 Aldosterone synthesis and secretion 10/250 105/7206 0.00336257865023 ko04720 Long-term potentiation 9/250 99/7206 0.00718530330538 ko04014 Ras signaling pathway 18/250 279/7206 0.0109205060671 ko00562 Inositol phosphate metabolism 8/250 89/7206 0.0117536184418 ko04960 Aldosterone-regulated sodium reabsorption 5/250 41/7206 0.0130494928642 ko05031 Amphetamine addiction 8/250 91/7206 0.0133350852858 ko04020 Calcium signaling pathway 17/250 265/7206 0.0147802587214 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/250 59/7206 0.0159082434059 ko04970 Salivary secretion 8/250 95/7206 0.0169568107055 ko04964 Proximal tubule bicarbonate reclamation 4/250 29/7206 0.016975488263 ko04217 Necroptosis 1/250 178/7206 0.0218121110007 ko05230 Central carbon metabolism in cancer 7/250 81/7206 0.0218494390442 ko05223 Non-small cell lung cancer 6/250 66/7206 0.0262879552525 ko05203 Viral carcinogenesis 3/250 277/7206 0.0271720136747 ko04921 Oxytocin signaling pathway 13/250 209/7206 0.0344556961013 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/250 1/7206 0.0346933111298 ko04745 Phototransduction - fly 4/250 38/7206 0.041467457786 ko04360 Axon guidance 14/250 233/7206 0.0425836758994 ko02010 ABC transporters 4/250 39/7206 0.0449949181387 ko04514 Cell adhesion molecules (CAMs) 9/250 130/7206 0.0461874330413 ko04068 FoxO signaling pathway 11/250 167/7206 0.0487012659297