ko pathway ratio_in_study ratio_in_pop p_value ko00190 Oxidative phosphorylation 56/728 127/7206 1.25100801358e-23 ko05010 Alzheimer's disease 52/728 202/7206 9.08995479227e-11 ko05012 Parkinson's disease 43/728 155/7206 3.21372650283e-10 ko04932 Non-alcoholic fatty liver disease (NAFLD) 45/728 182/7206 9.860359502e-09 ko04966 Collecting duct acid secretion 14/728 26/7206 3.10537926077e-08 ko05016 Huntington's disease 46/728 215/7206 7.30577028753e-07 ko04922 Glucagon signaling pathway 32/728 128/7206 8.29349490669e-07 ko04022 cGMP-PKG signaling pathway 45/728 216/7206 1.67099552645e-06 ko01200 Carbon metabolism 31/728 128/7206 3.61035346526e-06 ko05323 Rheumatoid arthritis 24/728 89/7206 4.80553024043e-06 ko00010 Glycolysis / Gluconeogenesis 21/728 74/7206 7.88403213591e-06 ko04723 Retrograde endocannabinoid signaling 37/728 175/7206 1.03105090276e-05 ko03010 Ribosome 1/728 129/7206 2.38676587758e-05 ko03040 Spliceosome 2/728 145/7206 4.02298682273e-05 ko04710 Circadian rhythm 14/728 43/7206 4.89068562697e-05 ko03013 RNA transport 4/728 166/7206 0.000211275799873 ko00680 Methane metabolism 11/728 34/7206 0.000335717791022 ko05110 Vibrio cholerae infection 16/728 63/7206 0.000386607352528 ko04721 Synaptic vesicle cycle 19/728 80/7206 0.000480976707664 ko04713 Circadian entrainment 27/728 136/7206 0.000483999133084 ko05203 Viral carcinogenesis 12/728 277/7206 0.000500172313826 ko00051 Fructose and mannose metabolism 12/728 42/7206 0.000655168643287 ko01230 Biosynthesis of amino acids 19/728 85/7206 0.000769091961692 ko04020 Calcium signaling pathway 44/728 265/7206 0.000810323799159 ko04371 Apelin signaling pathway 32/728 177/7206 0.000924305504326 ko04270 Vascular smooth muscle contraction 29/728 154/7206 0.000969676602152 ko04110 Cell cycle 4/728 145/7206 0.00119365672955 ko04137 Mitophagy - animal 18/728 82/7206 0.00128568212642 ko04970 Salivary secretion 20/728 95/7206 0.00151913360335 ko00620 Pyruvate metabolism 12/728 46/7206 0.00158024710443 ko04146 Peroxisome 19/728 89/7206 0.00199156088929 ko04610 Complement and coagulation cascades 17/728 79/7206 0.00214735344237 ko05150 Staphylococcus aureus infection 10/728 36/7206 0.00230662939797 ko04921 Oxytocin signaling pathway 35/728 209/7206 0.00231963701962 ko00120 Primary bile acid biosynthesis 7/728 20/7206 0.00249032392012 ko04066 HIF-1 signaling pathway 23/728 123/7206 0.0035521926187 ko04724 Glutamatergic synapse 27/728 152/7206 0.00377612197718 ko00710 Carbon fixation in photosynthetic organisms 8/728 27/7206 0.00404781255665 ko00071 Fatty acid degradation 11/728 45/7206 0.00424718667781 ko05230 Central carbon metabolism in cancer 17/728 81/7206 0.00430850814161 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/728 92/7206 0.00494099324947 ko04145 Phagosome 28/728 162/7206 0.0050594852431 ko04068 FoxO signaling pathway 28/728 167/7206 0.00615586506834 ko00020 Citrate cycle (TCA cycle) 9/728 35/7206 0.00660053960189 ko04626 Plant-pathogen interaction 6/728 18/7206 0.00667007582649 ko04514 Cell adhesion molecules (CAMs) 23/728 130/7206 0.00740153869862 ko04911 Insulin secretion 21/728 117/7206 0.00794118829543 ko04014 Ras signaling pathway 42/728 279/7206 0.0080740469644 ko04611 Platelet activation 27/728 163/7206 0.00838114512141 ko05322 Systemic lupus erythematosus 6/728 151/7206 0.00885834721827 ko04727 GABAergic synapse 20/728 110/7206 0.00954212649555 ko04657 IL-17 signaling pathway 2/728 87/7206 0.0108632497916 ko04640 Hematopoietic cell lineage 13/728 64/7206 0.0114932826765 ko04745 Phototransduction - fly 9/728 38/7206 0.0115881442904 ko02010 ABC transporters 9/728 39/7206 0.0137540803994 ko00362 Benzoate degradation 3/728 6/7206 0.0162568732649 ko01212 Fatty acid metabolism 12/728 60/7206 0.0169515974708 ko04141 Protein processing in endoplasmic reticulum 9/728 184/7206 0.0176209380538 ko00500 Starch and sucrose metabolism 8/728 35/7206 0.0208559238948 ko04120 Ubiquitin mediated proteolysis 6/728 138/7206 0.0214625202885 ko04925 Aldosterone synthesis and secretion 18/728 105/7206 0.0217216238445 ko04964 Proximal tubule bicarbonate reclamation 7/728 29/7206 0.022496468523 ko03015 mRNA surveillance pathway 3/728 93/7206 0.0230189075015 ko00270 Cysteine and methionine metabolism 10/728 47/7206 0.0236209115012 ko04725 Cholinergic synapse 25/728 160/7206 0.0238413115477 ko04070 Phosphatidylinositol signaling system 19/728 112/7206 0.0250555244818 ko04650 Natural killer cell mediated cytotoxicity 17/728 97/7206 0.025201617032 ko04971 Gastric acid secretion 17/728 98/7206 0.0261730086216 ko04614 Renin-angiotensin system 5/728 18/7206 0.0291497502398 ko04213 Longevity regulating pathway - multiple species 15/728 86/7206 0.030018689151 ko04136 Autophagy - other 7/728 31/7206 0.0317837731491 ko04111 Cell cycle - yeast 3/728 90/7206 0.0324411035582 ko04015 Rap1 signaling pathway 39/728 278/7206 0.0325481426753 ko04261 Adrenergic signaling in cardiomyocytes 30/728 205/7206 0.0340070635451 ko05152 Tuberculosis 28/728 187/7206 0.0353718402268 ko00592 alpha-Linolenic acid metabolism 5/728 19/7206 0.0363706687887 ko05032 Morphine addiction 18/728 110/7206 0.036778330971 ko00030 Pentose phosphate pathway 7/728 32/7206 0.0372665981508 ko04011 MAPK signaling pathway - yeast 1/728 53/7206 0.0394195815038 ko03050 Proteasome 1/728 54/7206 0.0395091722744 ko04138 Autophagy - yeast 14/728 81/7206 0.0398591763493 ko00052 Galactose metabolism 7/728 33/7206 0.0433364949549 ko04113 Meiosis - yeast 2/728 70/7206 0.0438206626312 ko04080 Neuroactive ligand-receptor interaction 55/728 423/7206 0.0457740531581 ko05034 Alcoholism 15/728 238/7206 0.0485415390498 ko04550 Signaling pathways regulating pluripotency of stem cells 9/728 165/7206 0.0487279261184