ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	104/869	145/7206	2.22055717848e-64
ko03013	RNA transport	79/869	166/7206	1.98590408312e-30
ko04110	Cell cycle	72/869	145/7206	2.80013956188e-29
ko03008	Ribosome biogenesis in eukaryotes	47/869	79/7206	6.26049979304e-24
ko03030	DNA replication	31/869	38/7206	1.12208624831e-22
ko04111	Cell cycle - yeast	49/869	90/7206	1.57029118779e-22
ko03460	Fanconi anemia pathway	33/869	51/7206	9.02398334233e-19
ko03440	Homologous recombination	28/869	41/7206	4.75681845715e-17
ko04113	Meiosis - yeast	34/869	70/7206	4.73536183601e-14
ko00240	Pyrimidine metabolism	43/869	110/7206	2.9106475655e-13
ko03420	Nucleotide excision repair	26/869	46/7206	4.75642894393e-13
ko03018	RNA degradation	36/869	84/7206	9.99858625752e-13
ko04020	Calcium signaling pathway	2/869	265/7206	1.43992627721e-12
ko03430	Mismatch repair	17/869	22/7206	3.05654854462e-12
ko03022	Basal transcription factors	24/869	44/7206	1.08364202608e-11
ko03015	mRNA surveillance pathway	36/869	93/7206	3.62676334222e-11
ko03410	Base excision repair	21/869	38/7206	1.55760108037e-10
ko03020	RNA polymerase	18/869	29/7206	2.33092431141e-10
ko04024	cAMP signaling pathway	8/869	279/7206	5.05520960217e-08
ko04144	Endocytosis	13/869	342/7206	8.76535033635e-08
ko05010	Alzheimer's disease	4/869	202/7206	2.40052384134e-07
ko04724	Glutamatergic synapse	2/869	152/7206	9.93201186375e-07
ko05169	Epstein-Barr virus infection	50/869	206/7206	1.04935803723e-06
ko04022	cGMP-PKG signaling pathway	6/869	216/7206	1.22414313329e-06
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/869	182/7206	2.37165466938e-06
ko00190	Oxidative phosphorylation	1/869	127/7206	2.74035123881e-06
ko04723	Retrograde endocannabinoid signaling	4/869	175/7206	4.97381635116e-06
ko04621	NOD-like receptor signaling pathway	3/869	157/7206	5.06549670962e-06
ko04270	Vascular smooth muscle contraction	3/869	154/7206	7.48464805453e-06
ko05012	Parkinson's disease	3/869	155/7206	7.74613591931e-06
ko05203	Viral carcinogenesis	59/869	277/7206	7.96454656697e-06
ko04911	Insulin secretion	1/869	117/7206	9.28874644251e-06
ko05414	Dilated cardiomyopathy	1/869	112/7206	1.34283501388e-05
ko04060	Cytokine-cytokine receptor interaction	6/869	191/7206	2.22515352882e-05
ko04810	Regulation of actin cytoskeleton	12/869	264/7206	2.96267344698e-05
ko04713	Circadian entrainment	3/869	136/7206	4.88612932349e-05
ko04921	Oxytocin signaling pathway	8/869	209/7206	5.2201289208e-05
ko04142	Lysosome	4/869	151/7206	6.51273653567e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	1/869	100/7206	6.93343531963e-05
ko00230	Purine metabolism	43/869	194/7206	7.08602219472e-05
ko04261	Adrenergic signaling in cardiomyocytes	8/869	205/7206	7.18211854413e-05
ko04725	Cholinergic synapse	5/869	160/7206	0.000108652059962
ko04971	Gastric acid secretion	1/869	98/7206	0.000110315979943
ko04151	PI3K-Akt signaling pathway	24/869	390/7206	0.000111509921055
ko04727	GABAergic synapse	2/869	110/7206	0.000162699319075
ko04371	Apelin signaling pathway	7/869	177/7206	0.000250325989521
ko04510	Focal adhesion	12/869	240/7206	0.000251551194824
ko04726	Serotonergic synapse	4/869	137/7206	0.000271396252316
ko04120	Ubiquitin mediated proteolysis	32/869	138/7206	0.000281432647548
ko05168	Herpes simplex infection	39/869	182/7206	0.000293351242414
ko04915	Estrogen signaling pathway	4/869	131/7206	0.000375990643125
ko04014	Ras signaling pathway	16/869	279/7206	0.000476239549391
ko04072	Phospholipase D signaling pathway	9/869	197/7206	0.000503783119799
ko05146	Amoebiasis	2/869	99/7206	0.000505554402907
ko03010	Ribosome	4/869	129/7206	0.000537365537747
ko05166	HTLV-I infection	55/869	292/7206	0.000632902666347
ko04721	Synaptic vesicle cycle	1/869	80/7206	0.000766612461149
ko04976	Bile secretion	1/869	80/7206	0.000766612461149
ko04740	Olfactory transduction	1/869	80/7206	0.000766612461149
ko04931	Insulin resistance	5/869	137/7206	0.000836912776967
ko03060	Protein export	9/869	23/7206	0.000875448721031
ko05032	Morphine addiction	3/869	110/7206	0.000950166550917
ko03450	Non-homologous end-joining	7/869	15/7206	0.000969667601064
ko04923	Regulation of lipolysis in adipocytes	1/869	77/7206	0.00115340733029
ko04728	Dopaminergic synapse	9/869	185/7206	0.0012311159334
ko04925	Aldosterone synthesis and secretion	3/869	105/7206	0.00133207090869
ko04114	Oocyte meiosis	30/869	139/7206	0.00136756572883
ko04218	Cellular senescence	36/869	177/7206	0.00143540800081
ko04630	Jak-STAT signaling pathway	5/869	132/7206	0.0016629228502
ko04062	Chemokine signaling pathway	11/869	201/7206	0.0020124401968
ko04924	Renin secretion	2/869	86/7206	0.00229055926505
ko04140	Autophagy - animal	8/869	164/7206	0.0022976307867
ko05322	Systemic lupus erythematosus	31/869	151/7206	0.00232696254418
ko04010	MAPK signaling pathway	22/869	321/7206	0.0027258310926
ko00564	Glycerophospholipid metabolism	3/869	99/7206	0.00273873700667
ko04972	Pancreatic secretion	4/869	111/7206	0.00300501974331
ko04070	Phosphatidylinositol signaling system	4/869	112/7206	0.00303743593658
ko04066	HIF-1 signaling pathway	5/869	123/7206	0.00315813253934
ko04611	Platelet activation	8/869	163/7206	0.00317632662987
ko04139	Mitophagy - yeast	11/869	37/7206	0.00323576502269
ko05145	Toxoplasmosis	5/869	126/7206	0.0032919552881
ko04668	TNF signaling pathway	5/869	120/7206	0.00437276929851
ko04380	Osteoclast differentiation	6/869	134/7206	0.0044665472452
ko04015	Rap1 signaling pathway	19/869	278/7206	0.00470730282651
ko04712	Circadian rhythm - plant	4/869	7/7206	0.00544145378733
ko04913	Ovarian steroidogenesis	1/869	63/7206	0.00548186045904
ko00600	Sphingolipid metabolism	1/869	63/7206	0.00548186045904
ko05031	Amphetamine addiction	3/869	91/7206	0.00548494802335
ko04922	Glucagon signaling pathway	6/869	128/7206	0.00601010439025
ko04540	Gap junction	6/869	128/7206	0.00601010439025
ko05142	Chagas disease (American trypanosomiasis)	6/869	130/7206	0.00605533782317
ko04659	Th17 cell differentiation	4/869	106/7206	0.0060736906982
ko05152	Tuberculosis	11/869	187/7206	0.00610906816087
ko04115	p53 signaling pathway	17/869	74/7206	0.00677797243389
ko05140	Leishmaniasis	2/869	75/7206	0.00688324711558
ko04145	Phagosome	9/869	162/7206	0.00706141606373
ko05133	Pertussis	3/869	87/7206	0.00777161912511
ko04662	B cell receptor signaling pathway	3/869	88/7206	0.00777553048806
ko04146	Peroxisome	3/869	89/7206	0.00787566795737
ko05323	Rheumatoid arthritis	3/869	89/7206	0.00787566795737
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/869	59/7206	0.00801262375731
ko04620	Toll-like receptor signaling pathway	4/869	100/7206	0.00819055214415
ko04910	Insulin signaling pathway	10/869	172/7206	0.00870954814191
ko04914	Progesterone-mediated oocyte maturation	22/869	104/7206	0.00888514173866
ko04152	AMPK signaling pathway	9/869	161/7206	0.00954033943331
ko05030	Cocaine addiction	2/869	73/7206	0.0101143578849
ko00010	Glycolysis / Gluconeogenesis	2/869	74/7206	0.0104324396252
ko05231	Choline metabolism in cancer	7/869	134/7206	0.0105904135653
ko04750	Inflammatory mediator regulation of TRP channels	6/869	122/7206	0.0110836391049
ko04650	Natural killer cell mediated cytotoxicity	4/869	97/7206	0.0113852431535
ko05160	Hepatitis C	9/869	153/7206	0.0163631535486
ko04330	Notch signaling pathway	14/869	62/7206	0.0171838038025
ko00280	Valine, leucine and isoleucine degradation	1/869	54/7206	0.0182453215213
ko01200	Carbon metabolism	7/869	128/7206	0.019027822194
ko00562	Inositol phosphate metabolism	4/869	89/7206	0.0216975164162
ko04730	Long-term depression	3/869	78/7206	0.0217113555348
ko04512	ECM-receptor interaction	3/869	79/7206	0.0220791990934
ko04660	T cell receptor signaling pathway	7/869	124/7206	0.0251769564797
ko05204	Chemical carcinogenesis	1/869	48/7206	0.0255102729157
ko00670	One carbon pool by folate	6/869	20/7206	0.02641244868
ko04530	Tight junction	17/869	228/7206	0.0295390388321
ko04213	Longevity regulating pathway - multiple species	4/869	86/7206	0.0297629763494
ko04918	Thyroid hormone synthesis	4/869	86/7206	0.0297629763494
ko00561	Glycerolipid metabolism	2/869	63/7206	0.0298809419085
ko03050	Proteasome	12/869	54/7206	0.0327449610522
ko05418	Fluid shear stress and atherosclerosis	12/869	173/7206	0.0333491389608
ko04912	GnRH signaling pathway	7/869	122/7206	0.0339165949823
ko04071	Sphingolipid signaling pathway	11/869	162/7206	0.0373534793071
ko00620	Pyruvate metabolism	1/869	46/7206	0.0379252313896
ko04658	Th1 and Th2 cell differentiation	5/869	96/7206	0.0388028318027
ko04360	Axon guidance	18/869	233/7206	0.0402667740529