ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 174/1092 423/7206 5.14618992679e-41 ko04724 Glutamatergic synapse 80/1092 152/7206 1.18907533648e-27 ko05033 Nicotine addiction 43/1092 56/7206 7.20300062392e-25 ko05032 Morphine addiction 56/1092 110/7206 9.02899420463e-19 ko04728 Dopaminergic synapse 76/1092 185/7206 4.92722378273e-18 ko04713 Circadian entrainment 62/1092 136/7206 1.4164114993e-17 ko04727 GABAergic synapse 53/1092 110/7206 1.7402404156e-16 ko04725 Cholinergic synapse 65/1092 160/7206 2.67943836222e-15 ko04020 Calcium signaling pathway 91/1092 265/7206 3.0495417316e-15 ko04024 cAMP signaling pathway 94/1092 279/7206 4.11115112421e-15 ko04723 Retrograde endocannabinoid signaling 68/1092 175/7206 8.58817260678e-15 ko04726 Serotonergic synapse 58/1092 137/7206 9.94959789524e-15 ko04721 Synaptic vesicle cycle 39/1092 80/7206 1.13175772927e-12 ko04911 Insulin secretion 47/1092 117/7206 3.34241904276e-11 ko04921 Oxytocin signaling pathway 68/1092 209/7206 2.01172118706e-10 ko04742 Taste transduction 30/1092 61/7206 3.59175560091e-10 ko04744 Phototransduction 21/1092 36/7206 2.93303754008e-09 ko04720 Long-term potentiation 39/1092 99/7206 3.14193769694e-09 ko05031 Amphetamine addiction 36/1092 91/7206 1.11472139706e-08 ko03010 Ribosome 1/1092 129/7206 1.78511173992e-08 ko03040 Spliceosome 2/1092 145/7206 2.63215313913e-08 ko05322 Systemic lupus erythematosus 3/1092 151/7206 1.06715184904e-07 ko04261 Adrenergic signaling in cardiomyocytes 60/1092 205/7206 1.66322160342e-07 ko04070 Phosphatidylinositol signaling system 37/1092 112/7206 1.69576054658e-06 ko04072 Phospholipase D signaling pathway 55/1092 197/7206 4.05063927223e-06 ko04730 Long-term depression 28/1092 78/7206 7.17523633213e-06 ko03013 RNA transport 7/1092 166/7206 8.95893090615e-06 ko04010 MAPK signaling pathway 78/1092 321/7206 1.03642993109e-05 ko04970 Salivary secretion 31/1092 95/7206 1.6719594194e-05 ko05030 Cocaine addiction 26/1092 73/7206 1.77215806e-05 ko04014 Ras signaling pathway 69/1092 279/7206 1.81444237515e-05 ko05203 Viral carcinogenesis 19/1092 277/7206 2.47847119992e-05 ko04110 Cell cycle 6/1092 145/7206 3.26362561131e-05 ko05169 Epstein-Barr virus infection 12/1092 206/7206 4.36421249145e-05 ko03008 Ribosome biogenesis in eukaryotes 1/1092 79/7206 5.20197892361e-05 ko04925 Aldosterone synthesis and secretion 32/1092 105/7206 5.35790769639e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 25/1092 74/7206 5.38335620787e-05 ko04745 Phototransduction - fly 16/1092 38/7206 5.65952265077e-05 ko04360 Axon guidance 58/1092 233/7206 8.21195929499e-05 ko04971 Gastric acid secretion 30/1092 98/7206 9.05874775982e-05 ko04022 cGMP-PKG signaling pathway 54/1092 216/7206 0.000146880615262 ko04141 Protein processing in endoplasmic reticulum 11/1092 184/7206 0.000153805074874 ko05231 Choline metabolism in cancer 37/1092 134/7206 0.000208190080187 ko05168 Herpes simplex infection 11/1092 182/7206 0.000212181081832 ko05164 Influenza A 10/1092 167/7206 0.000408906760966 ko04972 Pancreatic secretion 31/1092 111/7206 0.000448009935639 ko04514 Cell adhesion molecules (CAMs) 35/1092 130/7206 0.000462844115154 ko04750 Inflammatory mediator regulation of TRP channels 33/1092 122/7206 0.000776782509285 ko04120 Ubiquitin mediated proteolysis 8/1092 138/7206 0.00106422635478 ko04710 Circadian rhythm 15/1092 43/7206 0.0010707170886 ko04964 Proximal tubule bicarbonate reclamation 11/1092 29/7206 0.00229001301185 ko04621 NOD-like receptor signaling pathway 11/1092 157/7206 0.00230343206355 ko05162 Measles 7/1092 120/7206 0.00281263933256 ko04612 Antigen processing and presentation 3/1092 77/7206 0.00342552824455 ko04740 Olfactory transduction 22/1092 80/7206 0.00416816942261 ko04540 Gap junction 31/1092 128/7206 0.0059920860636 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/1092 182/7206 0.00633843518461 ko04930 Type II diabetes mellitus 16/1092 54/7206 0.00640938856766 ko04260 Cardiac muscle contraction 25/1092 98/7206 0.00661515060155 ko04960 Aldosterone-regulated sodium reabsorption 13/1092 41/7206 0.00698629341164 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/1092 79/7206 0.0070593823812 ko00562 Inositol phosphate metabolism 23/1092 89/7206 0.00721588964077 ko04060 Cytokine-cytokine receptor interaction 16/1092 191/7206 0.0074714966807 ko05166 HTLV-I infection 29/1092 292/7206 0.00965824564871 ko04924 Renin secretion 22/1092 86/7206 0.00985120636005 ko05130 Pathogenic Escherichia coli infection 4/1092 77/7206 0.0100938706958 ko03022 Basal transcription factors 1/1092 44/7206 0.0104385236941 ko05144 Malaria 1/1092 45/7206 0.0106345486107 ko03420 Nucleotide excision repair 1/1092 46/7206 0.0111479421968 ko04966 Collecting duct acid secretion 9/1092 26/7206 0.0111763060846 ko05230 Central carbon metabolism in cancer 21/1092 81/7206 0.0115616393654 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1092 14/7206 0.0120320032365 ko04626 Plant-pathogen interaction 7/1092 18/7206 0.0123813459649 ko05161 Hepatitis B 15/1092 173/7206 0.0134250110015 ko04630 Jak-STAT signaling pathway 10/1092 132/7206 0.0135790624812 ko04064 NF-kappa B signaling pathway 6/1092 96/7206 0.0138035738971 ko04915 Estrogen signaling pathway 30/1092 131/7206 0.0186466231997 ko04622 RIG-I-like receptor signaling pathway 3/1092 62/7206 0.019566181165 ko04015 Rap1 signaling pathway 56/1092 278/7206 0.0211270077006 ko03410 Base excision repair 1/1092 38/7206 0.0231529735835 ko05222 Small cell lung cancer 6/1092 89/7206 0.0246681503771 ko05016 Huntington's disease 21/1092 215/7206 0.0258768020149 ko04113 Meiosis - yeast 4/1092 70/7206 0.027669722477 ko05202 Transcriptional misregulation in cancer 18/1092 188/7206 0.0300755131232 ko04012 ErbB signaling pathway 25/1092 109/7206 0.0302171084887 ko05012 Parkinson's disease 14/1092 155/7206 0.0309892370335 ko05133 Pertussis 6/1092 87/7206 0.0336186973806 ko04711 Circadian rhythm - fly 5/1092 13/7206 0.0354121913204 ko05205 Proteoglycans in cancer 29/1092 271/7206 0.0379327297297 ko05214 Glioma 19/1092 79/7206 0.0383456879499 ko04142 Lysosome 14/1092 151/7206 0.0391311319526 ko04666 Fc gamma R-mediated phagocytosis 27/1092 122/7206 0.0403949411743 ko05145 Toxoplasmosis 11/1092 126/7206 0.0441925952178 ko04922 Glucagon signaling pathway 28/1092 128/7206 0.0453045847298