ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 24/277 80/7206 9.49949409236e-16 ko05033 Nicotine addiction 20/277 56/7206 5.68794806028e-15 ko04724 Glutamatergic synapse 31/277 152/7206 8.08708668774e-15 ko04728 Dopaminergic synapse 34/277 185/7206 9.90735834772e-15 ko04723 Retrograde endocannabinoid signaling 29/277 175/7206 1.54630047608e-11 ko04727 GABAergic synapse 22/277 110/7206 1.16274780497e-10 ko04713 Circadian entrainment 21/277 136/7206 4.08476347857e-08 ko04024 cAMP signaling pathway 31/277 279/7206 7.31915693495e-08 ko05032 Morphine addiction 18/277 110/7206 1.58838148369e-07 ko04010 MAPK signaling pathway 33/277 321/7206 1.75134060771e-07 ko04261 Adrenergic signaling in cardiomyocytes 23/277 205/7206 3.30075403987e-06 ko04911 Insulin secretion 16/277 117/7206 8.95109815394e-06 ko04725 Cholinergic synapse 19/277 160/7206 1.06695941319e-05 ko04514 Cell adhesion molecules (CAMs) 16/277 130/7206 3.44274811887e-05 ko04080 Neuroactive ligand-receptor interaction 34/277 423/7206 3.6137570199e-05 ko05031 Amphetamine addiction 12/277 91/7206 0.000171300585983 ko04726 Serotonergic synapse 15/277 137/7206 0.000230257118239 ko04071 Sphingolipid signaling pathway 16/277 162/7206 0.000468112219314 ko04730 Long-term depression 10/277 78/7206 0.000745846220365 ko04921 Oxytocin signaling pathway 18/277 209/7206 0.00133361780838 ko04720 Long-term potentiation 11/277 99/7206 0.00138288411347 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/277 14/7206 0.00157577705139 ko05030 Cocaine addiction 9/277 73/7206 0.00180332134715 ko05014 Amyotrophic lateral sclerosis (ALS) 9/277 74/7206 0.00198551511594 ko04666 Fc gamma R-mediated phagocytosis 12/277 122/7206 0.00244618816467 ko04360 Axon guidance 19/277 233/7206 0.00251321768562 ko04972 Pancreatic secretion 11/277 111/7206 0.0034583274207 ko04072 Phospholipase D signaling pathway 16/277 197/7206 0.00407785887048 ko05142 Chagas disease (American trypanosomiasis) 12/277 130/7206 0.00413841211419 ko04111 Cell cycle - yeast 9/277 90/7206 0.00744556573575 ko04742 Taste transduction 7/277 61/7206 0.00849054555019 ko04970 Salivary secretion 9/277 95/7206 0.0104946585205 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8/277 79/7206 0.0105732973755 ko04060 Cytokine-cytokine receptor interaction 1/277 191/7206 0.0110872484709 ko04260 Cardiac muscle contraction 9/277 98/7206 0.0127269255407 ko04966 Collecting duct acid secretion 4/277 26/7206 0.0163833383755 ko04930 Type II diabetes mellitus 6/277 54/7206 0.0167888202758 ko05210 Colorectal cancer 8/277 86/7206 0.0171017992759 ko04662 B cell receptor signaling pathway 8/277 88/7206 0.0194078241828 ko05167 Kaposi's sarcoma-associated herpesvirus infection 14/277 191/7206 0.0195890846621 ko04144 Endocytosis 21/277 342/7206 0.0299467836872 ko04940 Type I diabetes mellitus 4/277 32/7206 0.0329562407227 ko04915 Estrogen signaling pathway 10/277 131/7206 0.0346188617617 ko05203 Viral carcinogenesis 4/277 277/7206 0.0360456736604 ko04380 Osteoclast differentiation 10/277 134/7206 0.0381858272035 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/277 1/7206 0.0384401887318 ko03040 Spliceosome 1/277 145/7206 0.0457672869502 ko04141 Protein processing in endoplasmic reticulum 2/277 184/7206 0.0493955660314