ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 65/431 145/7206 5.41335827782e-42 ko03013 RNA transport 45/431 166/7206 1.21325027083e-18 ko04110 Cell cycle 39/431 145/7206 3.71578937834e-16 ko03440 Homologous recombination 21/431 41/7206 1.1310813624e-15 ko03008 Ribosome biogenesis in eukaryotes 28/431 79/7206 2.65433912002e-15 ko04111 Cell cycle - yeast 29/431 90/7206 1.4961212523e-14 ko03460 Fanconi anemia pathway 21/431 51/7206 2.74722048208e-13 ko03030 DNA replication 15/431 38/7206 1.52854322109e-09 ko04113 Meiosis - yeast 20/431 70/7206 2.21812054323e-09 ko00240 Pyrimidine metabolism 25/431 110/7206 4.19972176118e-09 ko03018 RNA degradation 20/431 84/7206 6.72166545129e-08 ko04144 Endocytosis 2/431 342/7206 2.41643980473e-07 ko03022 Basal transcription factors 13/431 44/7206 9.86553783105e-07 ko03410 Base excision repair 12/431 38/7206 1.1713647561e-06 ko03015 mRNA surveillance pathway 18/431 93/7206 7.55068928862e-06 ko03420 Nucleotide excision repair 12/431 46/7206 1.08555029985e-05 ko04151 PI3K-Akt signaling pathway 6/431 390/7206 2.22218873875e-05 ko04530 Tight junction 1/431 228/7206 2.25363206936e-05 ko03430 Mismatch repair 8/431 22/7206 2.33075557724e-05 ko03020 RNA polymerase 9/431 29/7206 3.08032367572e-05 ko04024 cAMP signaling pathway 3/431 279/7206 4.98756488908e-05 ko04114 Oocyte meiosis 21/431 139/7206 7.02166175106e-05 ko04510 Focal adhesion 2/431 240/7206 7.5980705144e-05 ko04914 Progesterone-mediated oocyte maturation 17/431 104/7206 0.000128034120741 ko04060 Cytokine-cytokine receptor interaction 1/431 191/7206 0.000150363296544 ko04261 Adrenergic signaling in cardiomyocytes 2/431 205/7206 0.000482783148535 ko04921 Oxytocin signaling pathway 2/431 209/7206 0.000503031031494 ko04810 Regulation of actin cytoskeleton 4/431 264/7206 0.000510287247844 ko05010 Alzheimer's disease 2/431 202/7206 0.000721874977937 ko05166 HTLV-I infection 32/431 292/7206 0.000884927318389 ko04621 NOD-like receptor signaling pathway 1/431 157/7206 0.00102909552222 ko04015 Rap1 signaling pathway 5/431 278/7206 0.00110261893283 ko04014 Ras signaling pathway 5/431 279/7206 0.00111061018122 ko04728 Dopaminergic synapse 2/431 185/7206 0.00144172548399 ko04724 Glutamatergic synapse 1/431 152/7206 0.00151437747739 ko05205 Proteoglycans in cancer 5/431 271/7206 0.00152585209555 ko05012 Parkinson's disease 1/431 155/7206 0.00157729737504 ko04022 cGMP-PKG signaling pathway 3/431 216/7206 0.00184163475324 ko04371 Apelin signaling pathway 2/431 177/7206 0.00206520379685 ko04723 Retrograde endocannabinoid signaling 2/431 175/7206 0.00306117245829 ko04611 Platelet activation 2/431 163/7206 0.00422366979651 ko04713 Circadian entrainment 1/431 136/7206 0.00499923133212 ko04010 MAPK signaling pathway 8/431 321/7206 0.00517361351942 ko04120 Ubiquitin mediated proteolysis 17/431 138/7206 0.00526921110117 ko04725 Cholinergic synapse 2/431 160/7206 0.00611005803717 ko04152 AMPK signaling pathway 2/431 161/7206 0.00618388717943 ko04066 HIF-1 signaling pathway 1/431 123/7206 0.00682930965917 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/431 182/7206 0.00683407091127 ko00190 Oxidative phosphorylation 1/431 127/7206 0.00697351685972 ko05152 Tuberculosis 3/431 187/7206 0.00700541093291 ko01200 Carbon metabolism 1/431 128/7206 0.0070808562657 ko04360 Axon guidance 5/431 233/7206 0.0073780921926 ko04911 Insulin secretion 1/431 117/7206 0.00991277183715 ko04062 Chemokine signaling pathway 4/431 201/7206 0.00996990672364 ko04668 TNF signaling pathway 1/431 120/7206 0.0100916520538 ko04750 Inflammatory mediator regulation of TRP channels 1/431 122/7206 0.0104117039686 ko00310 Lysine degradation 10/431 73/7206 0.0110543218834 ko04072 Phospholipase D signaling pathway 4/431 197/7206 0.0137882019578 ko04727 GABAergic synapse 1/431 110/7206 0.0143801671218 ko04972 Pancreatic secretion 1/431 111/7206 0.0143938930339 ko04726 Serotonergic synapse 2/431 137/7206 0.01713402021 ko05203 Viral carcinogenesis 26/431 277/7206 0.0195959512462 ko00230 Purine metabolism 20/431 194/7206 0.0196288706166 ko04139 Mitophagy - yeast 6/431 37/7206 0.0211703186324 ko05142 Chagas disease (American trypanosomiasis) 2/431 130/7206 0.0241426131202 ko04915 Estrogen signaling pathway 2/431 131/7206 0.0242210562841 ko04974 Protein digestion and absorption 1/431 96/7206 0.0301022748729 ko04971 Gastric acid secretion 1/431 98/7206 0.0301672159793 ko04720 Long-term potentiation 1/431 99/7206 0.030359675805 ko04666 Fc gamma R-mediated phagocytosis 2/431 122/7206 0.0339033183181 ko04660 T cell receptor signaling pathway 2/431 124/7206 0.0340100356851 ko05418 Fluid shear stress and atherosclerosis 4/431 173/7206 0.0343914732801 ko04910 Insulin signaling pathway 4/431 172/7206 0.0344152942556 ko05169 Epstein-Barr virus infection 20/431 206/7206 0.034825667228 ko05168 Herpes simplex infection 18/431 182/7206 0.0371836366106 ko05167 Kaposi's sarcoma-associated herpesvirus infection 5/431 191/7206 0.0438810686906