ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 23/289 134/7206 2.4622540623e-09 ko04621 NOD-like receptor signaling pathway 24/289 157/7206 1.19901643627e-08 ko04060 Cytokine-cytokine receptor interaction 26/289 191/7206 3.44339948574e-08 ko05164 Influenza A 23/289 167/7206 1.77574471874e-07 ko04064 NF-kappa B signaling pathway 17/289 96/7206 1.99216468303e-07 ko04650 Natural killer cell mediated cytotoxicity 17/289 97/7206 2.32921015789e-07 ko04630 Jak-STAT signaling pathway 19/289 132/7206 1.08993722738e-06 ko05140 Leishmaniasis 14/289 75/7206 1.25573063236e-06 ko05321 Inflammatory bowel disease (IBD) 12/289 56/7206 1.58093305672e-06 ko04620 Toll-like receptor signaling pathway 16/289 100/7206 1.89278836625e-06 ko05162 Measles 17/289 120/7206 5.07238204771e-06 ko04660 T cell receptor signaling pathway 17/289 124/7206 7.97331782675e-06 ko04672 Intestinal immune network for IgA production 9/289 37/7206 1.09479048123e-05 ko05168 Herpes simplex infection 21/289 182/7206 1.1104827851e-05 ko04610 Complement and coagulation cascades 13/289 79/7206 1.29355861901e-05 ko05152 Tuberculosis 21/289 187/7206 1.69067145572e-05 ko05161 Hepatitis B 20/289 173/7206 1.75485499622e-05 ko05145 Toxoplasmosis 16/289 126/7206 3.90805250873e-05 ko05323 Rheumatoid arthritis 13/289 89/7206 4.80643294193e-05 ko05150 Staphylococcus aureus infection 8/289 36/7206 6.89200111905e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/289 191/7206 7.37619441693e-05 ko04668 TNF signaling pathway 15/289 120/7206 8.19534563601e-05 ko04611 Platelet activation 18/289 163/7206 8.52498083589e-05 ko04217 Necroptosis 19/289 178/7206 8.62677449874e-05 ko04658 Th1 and Th2 cell differentiation 13/289 96/7206 0.000107258612522 ko05320 Autoimmune thyroid disease 7/289 29/7206 0.000113153196219 ko05340 Primary immunodeficiency 7/289 30/7206 0.000142585975854 ko04662 B cell receptor signaling pathway 12/289 88/7206 0.000184290362516 ko05330 Allograft rejection 6/289 24/7206 0.000288424580474 ko05144 Malaria 8/289 45/7206 0.000358638289781 ko04622 RIG-I-like receptor signaling pathway 9/289 62/7206 0.000740083437163 ko04664 Fc epsilon RI signaling pathway 10/289 77/7206 0.00093356849544 ko04659 Th17 cell differentiation 12/289 106/7206 0.00103801658369 ko04210 Apoptosis 16/289 180/7206 0.0028435095629 ko05310 Asthma 4/289 17/7206 0.0039856375231 ko00590 Arachidonic acid metabolism 7/289 52/7206 0.00440857519979 ko05332 Graft-versus-host disease 4/289 18/7206 0.00496492599922 ko05160 Hepatitis C 14/289 153/7206 0.00500659313471 ko04137 Mitophagy - animal 9/289 82/7206 0.00531755189142 ko04623 Cytosolic DNA-sensing pathway 6/289 41/7206 0.00543700984104 ko05142 Chagas disease (American trypanosomiasis) 12/289 130/7206 0.00579114413898 ko04080 Neuroactive ligand-receptor interaction 7/289 423/7206 0.00707303139536 ko04728 Dopaminergic synapse 1/289 185/7206 0.00715495822526 ko04917 Prolactin signaling pathway 9/289 87/7206 0.00782358503939 ko05166 HTLV-I infection 21/289 292/7206 0.00877429427998 ko04062 Chemokine signaling pathway 16/289 201/7206 0.00899695530925 ko05134 Legionellosis 8/289 74/7206 0.0092012465161 ko04670 Leukocyte transendothelial migration 13/289 151/7206 0.009375985369 ko04666 Fc gamma R-mediated phagocytosis 11/289 122/7206 0.00959504214823 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/289 135/7206 0.0115611848788 ko04145 Phagosome 13/289 162/7206 0.0142563575439 ko05416 Viral myocarditis 6/289 55/7206 0.0220137080775 ko04657 IL-17 signaling pathway 8/289 87/7206 0.0228790367801 ko05133 Pertussis 8/289 87/7206 0.0228790367801 ko00051 Fructose and mannose metabolism 5/289 42/7206 0.0253233118096 ko05034 Alcoholism 3/289 238/7206 0.0268019326587 ko04115 p53 signaling pathway 7/289 74/7206 0.0282053793247 ko04612 Antigen processing and presentation 7/289 77/7206 0.0340913906799 ko04390 Hippo signaling pathway 2/289 188/7206 0.0355882115363 ko04940 Type I diabetes mellitus 4/289 32/7206 0.0376642972757 ko00592 alpha-Linolenic acid metabolism 3/289 19/7206 0.0384352818791 ko04072 Phospholipase D signaling pathway 14/289 197/7206 0.0393029992157 ko04514 Cell adhesion molecules (CAMs) 10/289 130/7206 0.0402430947632 ko00120 Primary bile acid biosynthesis 3/289 20/7206 0.0439155392003 ko05215 Prostate cancer 9/289 111/7206 0.0439605210933 ko04120 Ubiquitin mediated proteolysis 1/289 138/7206 0.0453858406273 ko05131 Shigellosis 7/289 82/7206 0.0456167150062 ko05169 Epstein-Barr virus infection 14/289 206/7206 0.0464031966598 ko04916 Melanogenesis 1/289 142/7206 0.0469529293546