ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 30/396 157/7206 1.25524768344e-09 ko05164 Influenza A 29/396 167/7206 2.32512983837e-08 ko04060 Cytokine-cytokine receptor interaction 30/396 191/7206 1.38213669427e-07 ko04620 Toll-like receptor signaling pathway 20/396 100/7206 3.57307064787e-07 ko05162 Measles 22/396 120/7206 4.57417348727e-07 ko04064 NF-kappa B signaling pathway 19/396 96/7206 8.33621302941e-07 ko05321 Inflammatory bowel disease (IBD) 14/396 56/7206 1.26860459206e-06 ko04630 Jak-STAT signaling pathway 22/396 132/7206 2.45784837634e-06 ko04380 Osteoclast differentiation 22/396 134/7206 3.18118455252e-06 ko04668 TNF signaling pathway 20/396 120/7206 7.07784523832e-06 ko05140 Leishmaniasis 15/396 75/7206 1.05727694114e-05 ko04650 Natural killer cell mediated cytotoxicity 17/396 97/7206 1.75382503338e-05 ko05168 Herpes simplex infection 24/396 182/7206 8.23190212235e-05 ko05152 Tuberculosis 24/396 187/7206 0.000103815569732 ko04660 T cell receptor signaling pathway 18/396 124/7206 0.000133172955404 ko04217 Necroptosis 23/396 178/7206 0.000140772935412 ko05340 Primary immunodeficiency 8/396 30/7206 0.000155515622282 ko05145 Toxoplasmosis 18/396 126/7206 0.000163992141443 ko05323 Rheumatoid arthritis 14/396 89/7206 0.000316359711558 ko04710 Circadian rhythm 9/396 43/7206 0.000443157227121 ko05161 Hepatitis B 21/396 173/7206 0.000538063605252 ko05150 Staphylococcus aureus infection 8/396 36/7206 0.000601411885014 ko04658 Th1 and Th2 cell differentiation 14/396 96/7206 0.000698248133125 ko04672 Intestinal immune network for IgA production 8/396 37/7206 0.000731154087349 ko04610 Complement and coagulation cascades 12/396 79/7206 0.00115248649976 ko04210 Apoptosis 21/396 180/7206 0.00122021489674 ko04137 Mitophagy - animal 12/396 82/7206 0.00160680690483 ko04659 Th17 cell differentiation 14/396 106/7206 0.00187047719804 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/396 191/7206 0.00198793225383 ko04662 B cell receptor signaling pathway 12/396 88/7206 0.00295966685402 ko00120 Primary bile acid biosynthesis 5/396 20/7206 0.00381240397275 ko04062 Chemokine signaling pathway 21/396 201/7206 0.00413743912685 ko05320 Autoimmune thyroid disease 6/396 29/7206 0.00427935314335 ko04611 Platelet activation 18/396 163/7206 0.00446952374984 ko05142 Chagas disease (American trypanosomiasis) 15/396 130/7206 0.00553398912845 ko04622 RIG-I-like receptor signaling pathway 9/396 62/7206 0.00633956959558 ko00140 Steroid hormone biosynthesis 7/396 41/7206 0.00636478879358 ko04623 Cytosolic DNA-sensing pathway 7/396 41/7206 0.00636478879358 ko05134 Legionellosis 10/396 74/7206 0.00686709890356 ko00590 Arachidonic acid metabolism 8/396 52/7206 0.00693773348597 ko00051 Fructose and mannose metabolism 7/396 42/7206 0.00728639245493 ko05133 Pertussis 11/396 87/7206 0.00775264130755 ko04145 Phagosome 17/396 162/7206 0.00849994593838 ko05330 Allograft rejection 5/396 24/7206 0.00872114253792 ko03013 RNA transport 2/396 166/7206 0.00873752939544 ko04664 Fc epsilon RI signaling pathway 10/396 77/7206 0.00906420487561 ko03010 Ribosome 1/396 129/7206 0.0100936334993 ko04670 Leukocyte transendothelial migration 16/396 151/7206 0.0103140088605 ko05144 Malaria 7/396 45/7206 0.0106444575102 ko05160 Hepatitis C 16/396 153/7206 0.0112428037814 ko04390 Hippo signaling pathway 3/396 188/7206 0.0136626024805 ko05332 Graft-versus-host disease 4/396 18/7206 0.0148644029457 ko00592 alpha-Linolenic acid metabolism 4/396 19/7206 0.0180303292533 ko04115 p53 signaling pathway 9/396 74/7206 0.0194102557133 ko04080 Neuroactive ligand-receptor interaction 13/396 423/7206 0.0207455169001 ko03040 Spliceosome 2/396 145/7206 0.0248946748364 ko04110 Cell cycle 2/396 145/7206 0.0248946748364 ko04068 FoxO signaling pathway 16/396 167/7206 0.025145428214 ko04723 Retrograde endocannabinoid signaling 3/396 175/7206 0.0267124615613 ko04917 Prolactin signaling pathway 10/396 87/7206 0.027479459964 ko04657 IL-17 signaling pathway 10/396 87/7206 0.027479459964 ko04612 Antigen processing and presentation 9/396 77/7206 0.0371263781124 ko00362 Benzoate degradation 2/396 6/7206 0.0389933650803 ko04666 Fc gamma R-mediated phagocytosis 12/396 122/7206 0.0431444866888 ko05131 Shigellosis 9/396 82/7206 0.0446027557567 ko04350 TGF-beta signaling pathway 1/396 103/7206 0.0454317596368 ko01200 Carbon metabolism 2/396 128/7206 0.0481387871244 ko04540 Gap junction 2/396 128/7206 0.0481387871244