ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1145	423/7206	1.21622828512e-59
ko05033	Nicotine addiction	49/1145	56/7206	2.20746687555e-32
ko04724	Glutamatergic synapse	86/1145	152/7206	3.27717801582e-31
ko05032	Morphine addiction	68/1145	110/7206	4.44276731384e-28
ko04713	Circadian entrainment	74/1145	136/7206	1.62733824656e-25
ko04727	GABAergic synapse	65/1145	110/7206	2.76372540726e-25
ko04725	Cholinergic synapse	78/1145	160/7206	8.37239733302e-23
ko04728	Dopaminergic synapse	84/1145	185/7206	6.93952294035e-22
ko04721	Synaptic vesicle cycle	50/1145	80/7206	3.06355455198e-21
ko04024	cAMP signaling pathway	106/1145	279/7206	7.44426941305e-20
ko04020	Calcium signaling pathway	101/1145	265/7206	3.34128109346e-19
ko04911	Insulin secretion	60/1145	117/7206	3.52282771285e-19
ko04723	Retrograde endocannabinoid signaling	75/1145	175/7206	7.29430544724e-18
ko04742	Taste transduction	37/1145	61/7206	1.99547609598e-15
ko04921	Oxytocin signaling pathway	77/1145	209/7206	6.44731232989e-14
ko04726	Serotonergic synapse	58/1145	137/7206	8.51539685026e-14
ko04261	Adrenergic signaling in cardiomyocytes	74/1145	205/7206	8.1594378775e-13
ko05031	Amphetamine addiction	42/1145	91/7206	7.88569521184e-12
ko04744	Phototransduction	24/1145	36/7206	9.77744645319e-12
ko04720	Long-term potentiation	44/1145	99/7206	1.22924609548e-11
ko04970	Salivary secretion	42/1145	95/7206	4.46459309515e-11
ko04360	Axon guidance	75/1145	233/7206	3.88671496851e-10
ko03040	Spliceosome	1/1145	145/7206	5.15735288073e-10
ko04740	Olfactory transduction	36/1145	80/7206	6.03331101934e-10
ko04925	Aldosterone synthesis and secretion	41/1145	105/7206	7.13746482781e-09
ko04971	Gastric acid secretion	39/1145	98/7206	8.87313743658e-09
ko05030	Cocaine addiction	31/1145	73/7206	5.05173804539e-08
ko05168	Herpes simplex infection	6/1145	182/7206	8.40386160217e-08
ko05203	Viral carcinogenesis	15/1145	277/7206	8.53530426664e-08
ko05322	Systemic lupus erythematosus	4/1145	151/7206	2.09128595279e-07
ko04022	cGMP-PKG signaling pathway	64/1145	216/7206	2.2544425745e-07
ko04010	MAPK signaling pathway	85/1145	321/7206	6.7206175003e-07
ko04060	Cytokine-cytokine receptor interaction	9/1145	191/7206	1.77182963839e-06
ko04972	Pancreatic secretion	38/1145	111/7206	2.29409990893e-06
ko03013	RNA transport	7/1145	166/7206	2.84080945356e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1145	74/7206	6.19877393463e-06
ko04730	Long-term depression	28/1145	78/7206	1.30870061987e-05
ko05164	Influenza A	8/1145	167/7206	1.34028598491e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1145	79/7206	1.66419130399e-05
ko04745	Phototransduction - fly	17/1145	38/7206	2.39364150113e-05
ko04540	Gap junction	39/1145	128/7206	4.00713012417e-05
ko04966	Collecting duct acid secretion	13/1145	26/7206	5.23992014281e-05
ko04141	Protein processing in endoplasmic reticulum	11/1145	184/7206	5.62224958982e-05
ko04072	Phospholipase D signaling pathway	53/1145	197/7206	6.43398561845e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1145	59/7206	8.69293388877e-05
ko04514	Cell adhesion molecules (CAMs)	38/1145	130/7206	0.00013443136387
ko04750	Inflammatory mediator regulation of TRP channels	36/1145	122/7206	0.000137663897231
ko04621	NOD-like receptor signaling pathway	9/1145	157/7206	0.000146344744961
ko05110	Vibrio cholerae infection	22/1145	63/7206	0.000178043085014
ko04110	Cell cycle	8/1145	145/7206	0.000199835493819
ko04014	Ras signaling pathway	68/1145	279/7206	0.000214481186997
ko04260	Cardiac muscle contraction	30/1145	98/7206	0.000228654906638
ko04610	Complement and coagulation cascades	2/1145	79/7206	0.000267611758589
ko03008	Ribosome biogenesis in eukaryotes	2/1145	79/7206	0.000267611758589
ko04924	Renin secretion	27/1145	86/7206	0.000283780317951
ko05414	Dilated cardiomyopathy	33/1145	112/7206	0.000344161745883
ko04120	Ubiquitin mediated proteolysis	8/1145	138/7206	0.000382747935586
ko04612	Antigen processing and presentation	2/1145	77/7206	0.000407820171962
ko04976	Bile secretion	25/1145	80/7206	0.000548345118787
ko04070	Phosphatidylinositol signaling system	32/1145	112/7206	0.000597320692638
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1145	182/7206	0.000624343711216
ko05169	Epstein-Barr virus infection	16/1145	206/7206	0.000660165644743
ko04371	Apelin signaling pathway	45/1145	177/7206	0.00112767275461
ko00240	Pyrimidine metabolism	6/1145	110/7206	0.00139504624769
ko05162	Measles	7/1145	120/7206	0.00143077774066
ko04915	Estrogen signaling pathway	35/1145	131/7206	0.00150973305249
ko05205	Proteoglycans in cancer	25/1145	271/7206	0.00163853929325
ko04146	Peroxisome	4/1145	89/7206	0.00182609867301
ko00590	Arachidonic acid metabolism	1/1145	52/7206	0.00200371102304
ko05140	Leishmaniasis	3/1145	75/7206	0.00222600841525
ko04640	Hematopoietic cell lineage	2/1145	64/7206	0.00284083934473
ko00310	Lysine degradation	3/1145	73/7206	0.0032465630924
ko04015	Rap1 signaling pathway	62/1145	278/7206	0.00429825353546
ko04912	GnRH signaling pathway	31/1145	122/7206	0.00576091232175
ko03022	Basal transcription factors	1/1145	44/7206	0.00679291621033
ko05144	Malaria	1/1145	45/7206	0.00679662292702
ko00071	Fatty acid degradation	1/1145	45/7206	0.00679662292702
ko04658	Th1 and Th2 cell differentiation	6/1145	96/7206	0.00701990833887
ko04064	NF-kappa B signaling pathway	6/1145	96/7206	0.00701990833887
ko03420	Nucleotide excision repair	1/1145	46/7206	0.00703491137353
ko04657	IL-17 signaling pathway	5/1145	87/7206	0.00719493809225
ko05231	Choline metabolism in cancer	33/1145	134/7206	0.00823841105689
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1145	100/7206	0.00839659259102
ko00480	Glutathione metabolism	2/1145	55/7206	0.00852689836176
ko05321	Inflammatory bowel disease (IBD)	2/1145	56/7206	0.00880764498813
ko04217	Necroptosis	16/1145	178/7206	0.00916412553782
ko03018	RNA degradation	5/1145	84/7206	0.0099045026586
ko05016	Huntington's disease	21/1145	215/7206	0.0104709768203
ko04071	Sphingolipid signaling pathway	38/1145	162/7206	0.0118952729519
ko00330	Arginine and proline metabolism	3/1145	61/7206	0.0133942684662
ko04622	RIG-I-like receptor signaling pathway	3/1145	62/7206	0.0134800569285
ko05131	Shigellosis	5/1145	82/7206	0.0139091524902
ko04214	Apoptosis - fly	4/1145	72/7206	0.0139204010824
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1145	14/7206	0.0151193949805
ko04626	Plant-pathogen interaction	7/1145	18/7206	0.0159505565538
ko04973	Carbohydrate digestion and absorption	13/1145	42/7206	0.0169675907367
ko04918	Thyroid hormone synthesis	22/1145	86/7206	0.0174358062549
ko04964	Proximal tubule bicarbonate reclamation	10/1145	29/7206	0.0175017061611
ko05166	HTLV-I infection	32/1145	292/7206	0.0176128769964
ko05133	Pertussis	6/1145	87/7206	0.0177170320888
ko04350	TGF-beta signaling pathway	8/1145	103/7206	0.0205353518733
ko03410	Base excision repair	1/1145	38/7206	0.023190736686
ko04923	Regulation of lipolysis in adipocytes	20/1145	77/7206	0.0264955423901
ko05161	Hepatitis B	17/1145	173/7206	0.0266524775606
ko00260	Glycine, serine and threonine metabolism	2/1145	48/7206	0.0267048254657
ko04620	Toll-like receptor signaling pathway	8/1145	100/7206	0.0271797528293
ko04722	Neurotrophin signaling pathway	36/1145	160/7206	0.0279775742139
ko05214	Glioma	20/1145	79/7206	0.0290306137914
ko04960	Aldosterone-regulated sodium reabsorption	12/1145	41/7206	0.0292513139128
ko00860	Porphyrin and chlorophyll metabolism	1/1145	34/7206	0.0335295865705
ko04975	Fat digestion and absorption	1/1145	35/7206	0.0340250184698
ko05012	Parkinson's disease	15/1145	155/7206	0.0341300068019
ko04115	p53 signaling pathway	5/1145	74/7206	0.0357604901637
ko04916	Melanogenesis	32/1145	142/7206	0.0361306438536
ko04330	Notch signaling pathway	4/1145	62/7206	0.0367047690227
ko00280	Valine, leucine and isoleucine degradation	3/1145	54/7206	0.0380253478706
ko04922	Glucagon signaling pathway	29/1145	128/7206	0.0383153935914
ko04142	Lysosome	15/1145	151/7206	0.0426680985646
ko05418	Fluid shear stress and atherosclerosis	18/1145	173/7206	0.0454000916558
ko03320	PPAR signaling pathway	5/1145	69/7206	0.0470146371779
ko04113	Meiosis - yeast	5/1145	70/7206	0.0472617778463
ko05034	Alcoholism	49/1145	238/7206	0.047301155729
ko05145	Toxoplasmosis	12/1145	126/7206	0.0489442943881
ko01200	Carbon metabolism	12/1145	128/7206	0.0497395848483