ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 40/420 152/7206 1.40650849018e-16 ko04911 Insulin secretion 29/420 117/7206 1.27703965909e-11 ko04727 GABAergic synapse 27/420 110/7206 8.48770575212e-11 ko05033 Nicotine addiction 18/420 56/7206 1.14278135569e-09 ko05032 Morphine addiction 25/420 110/7206 2.46354958544e-09 ko04713 Circadian entrainment 28/420 136/7206 2.93070541768e-09 ko04721 Synaptic vesicle cycle 20/420 80/7206 1.78823337798e-08 ko04728 Dopaminergic synapse 32/420 185/7206 1.96722889912e-08 ko04725 Cholinergic synapse 29/420 160/7206 3.19442747945e-08 ko04723 Retrograde endocannabinoid signaling 30/420 175/7206 6.84053667826e-08 ko04070 Phosphatidylinositol signaling system 23/420 112/7206 8.24873615474e-08 ko04726 Serotonergic synapse 25/420 137/7206 2.54656485933e-07 ko04970 Salivary secretion 20/420 95/7206 3.82834554704e-07 ko04020 Calcium signaling pathway 37/420 265/7206 5.78423680523e-07 ko04024 cAMP signaling pathway 37/420 279/7206 2.47282266181e-06 ko04720 Long-term potentiation 19/420 99/7206 3.28643959922e-06 ko04080 Neuroactive ligand-receptor interaction 47/420 423/7206 1.40189136549e-05 ko04972 Pancreatic secretion 19/420 111/7206 1.86329003512e-05 ko04925 Aldosterone synthesis and secretion 18/420 105/7206 3.02341962543e-05 ko04360 Axon guidance 30/420 233/7206 4.14118549014e-05 ko04971 Gastric acid secretion 17/420 98/7206 4.28932431875e-05 ko04261 Adrenergic signaling in cardiomyocytes 27/420 205/7206 5.55933330921e-05 ko04514 Cell adhesion molecules (CAMs) 20/420 130/7206 5.59624745421e-05 ko04750 Inflammatory mediator regulation of TRP channels 19/420 122/7206 7.22457601197e-05 ko04072 Phospholipase D signaling pathway 26/420 197/7206 7.50295747169e-05 ko04921 Oxytocin signaling pathway 27/420 209/7206 0.0001148033325 ko04022 cGMP-PKG signaling pathway 27/420 216/7206 0.000156530973164 ko04930 Type II diabetes mellitus 11/420 54/7206 0.000226577302356 ko04960 Aldosterone-regulated sodium reabsorption 9/420 41/7206 0.00046925155765 ko00562 Inositol phosphate metabolism 14/420 89/7206 0.000573969453061 ko04010 MAPK signaling pathway 34/420 321/7206 0.000574673558575 ko04710 Circadian rhythm 9/420 43/7206 0.000680880012915 ko05031 Amphetamine addiction 14/420 91/7206 0.000722048177652 ko04964 Proximal tubule bicarbonate reclamation 7/420 29/7206 0.00110583323033 ko04745 Phototransduction - fly 8/420 38/7206 0.00129461724262 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/420 59/7206 0.00194397356942 ko05322 Systemic lupus erythematosus 1/420 151/7206 0.0022697772916 ko05030 Cocaine addiction 11/420 73/7206 0.00310507621392 ko05014 Amyotrophic lateral sclerosis (ALS) 11/420 74/7206 0.0034615056741 ko04918 Thyroid hormone synthesis 12/420 86/7206 0.00394008286882 ko04730 Long-term depression 11/420 78/7206 0.00522806544917 ko03013 RNA transport 2/420 166/7206 0.00628122365145 ko04740 Olfactory transduction 11/420 80/7206 0.00634510212599 ko04071 Sphingolipid signaling pathway 18/420 162/7206 0.00944637178076 ko05168 Herpes simplex infection 3/420 182/7206 0.00959518092795 ko04141 Protein processing in endoplasmic reticulum 3/420 184/7206 0.00972508368369 ko04973 Carbohydrate digestion and absorption 7/420 42/7206 0.00994459034803 ko04540 Gap junction 15/420 128/7206 0.0111638653262 ko03040 Spliceosome 2/420 145/7206 0.0178332522605 ko04110 Cell cycle 2/420 145/7206 0.0178332522605 ko04014 Ras signaling pathway 26/420 279/7206 0.0179089808204 ko04013 MAPK signaling pathway - fly 13/420 115/7206 0.0237609193761 ko04060 Cytokine-cytokine receptor interaction 4/420 191/7206 0.0264391748462 ko05110 Vibrio cholerae infection 8/420 63/7206 0.0288962860005 ko04260 Cardiac muscle contraction 11/420 98/7206 0.0293762180948 ko05203 Viral carcinogenesis 8/420 277/7206 0.0350237249699 ko04114 Oocyte meiosis 14/420 139/7206 0.041829953901 ko04064 NF-kappa B signaling pathway 1/420 96/7206 0.0444786415003 ko04919 Thyroid hormone signaling pathway 14/420 143/7206 0.0472387217346 ko04371 Apelin signaling pathway 17/420 177/7206 0.0484447016769 ko04015 Rap1 signaling pathway 24/420 278/7206 0.049279215777