ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1162	423/7206	2.11417122642e-50
ko04724	Glutamatergic synapse	93/1162	152/7206	4.86149053944e-37
ko05033	Nicotine addiction	49/1162	56/7206	4.52796361784e-32
ko05032	Morphine addiction	71/1162	110/7206	1.3274777418e-30
ko04713	Circadian entrainment	80/1162	136/7206	2.9889376076e-30
ko04727	GABAergic synapse	68/1162	110/7206	1.11077974822e-27
ko04728	Dopaminergic synapse	89/1162	185/7206	6.8141803216e-25
ko04725	Cholinergic synapse	79/1162	160/7206	4.11049444265e-23
ko04721	Synaptic vesicle cycle	52/1162	80/7206	6.62728409539e-23
ko04723	Retrograde endocannabinoid signaling	80/1162	175/7206	1.0592553964e-20
ko04911	Insulin secretion	61/1162	117/7206	1.27427205648e-19
ko04024	cAMP signaling pathway	106/1162	279/7206	1.77938934517e-19
ko04020	Calcium signaling pathway	98/1162	265/7206	4.05416499351e-17
ko04726	Serotonergic synapse	63/1162	137/7206	1.08386905767e-16
ko04921	Oxytocin signaling pathway	83/1162	209/7206	1.43515025594e-16
ko04742	Taste transduction	38/1162	61/7206	3.80557736826e-16
ko04720	Long-term potentiation	49/1162	99/7206	7.95046809893e-15
ko05031	Amphetamine addiction	45/1162	91/7206	1.05827262931e-13
ko04970	Salivary secretion	45/1162	95/7206	7.53531106676e-13
ko04744	Phototransduction	25/1162	36/7206	1.21144165392e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1162	205/7206	1.45466608008e-12
ko04740	Olfactory transduction	40/1162	80/7206	1.59806495358e-12
ko04925	Aldosterone synthesis and secretion	44/1162	105/7206	2.1953312333e-10
ko04971	Gastric acid secretion	42/1162	98/7206	2.42171841342e-10
ko03040	Spliceosome	1/1162	145/7206	3.14582301038e-10
ko05168	Herpes simplex infection	6/1162	182/7206	5.54134402929e-08
ko05030	Cocaine addiction	31/1162	73/7206	7.16980565504e-08
ko04540	Gap junction	45/1162	128/7206	1.36778670072e-07
ko04360	Axon guidance	69/1162	233/7206	1.56023291802e-07
ko04022	cGMP-PKG signaling pathway	65/1162	216/7206	2.42236993013e-07
ko04972	Pancreatic secretion	39/1162	111/7206	7.32196066189e-07
ko04060	Cytokine-cytokine receptor interaction	9/1162	191/7206	1.21078443966e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1162	74/7206	1.43429366943e-06
ko05203	Viral carcinogenesis	18/1162	277/7206	1.56727842454e-06
ko04966	Collecting duct acid secretion	15/1162	26/7206	1.5714662868e-06
ko04730	Long-term depression	30/1162	78/7206	2.52886871925e-06
ko04010	MAPK signaling pathway	84/1162	321/7206	2.60486638173e-06
ko03013	RNA transport	7/1162	166/7206	2.87105371248e-06
ko04070	Phosphatidylinositol signaling system	38/1162	112/7206	3.09863711041e-06
ko05322	Systemic lupus erythematosus	6/1162	151/7206	5.03745437713e-06
ko04745	Phototransduction - fly	18/1162	38/7206	6.30299633385e-06
ko04621	NOD-like receptor signaling pathway	7/1162	157/7206	8.13679989584e-06
ko04514	Cell adhesion molecules (CAMs)	41/1162	130/7206	9.99916777984e-06
ko04141	Protein processing in endoplasmic reticulum	10/1162	184/7206	1.50479584723e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1162	122/7206	1.55232930944e-05
ko04924	Renin secretion	30/1162	86/7206	1.94848416299e-05
ko04072	Phospholipase D signaling pathway	55/1162	197/7206	1.99752228029e-05
ko05110	Vibrio cholerae infection	24/1162	63/7206	2.02008181031e-05
ko05164	Influenza A	9/1162	167/7206	2.71536957795e-05
ko04120	Ubiquitin mediated proteolysis	6/1162	138/7206	3.09715313175e-05
ko04110	Cell cycle	7/1162	145/7206	4.91775781669e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1162	79/7206	7.42701845919e-05
ko04915	Estrogen signaling pathway	39/1162	131/7206	9.42358039738e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1162	59/7206	9.49184477231e-05
ko04260	Cardiac muscle contraction	31/1162	98/7206	0.000133493616529
ko05414	Dilated cardiomyopathy	34/1162	112/7206	0.000137606448508
ko04371	Apelin signaling pathway	48/1162	177/7206	0.000167356087603
ko04014	Ras signaling pathway	69/1162	279/7206	0.000168555405169
ko04610	Complement and coagulation cascades	2/1162	79/7206	0.000173831360937
ko03008	Ribosome biogenesis in eukaryotes	2/1162	79/7206	0.000173831360937
ko05162	Measles	6/1162	120/7206	0.000247539873562
ko04612	Antigen processing and presentation	2/1162	77/7206	0.000257772112834
ko04976	Bile secretion	26/1162	80/7206	0.000307282031789
ko04064	NF-kappa B signaling pathway	4/1162	96/7206	0.000406563603151
ko04912	GnRH signaling pathway	35/1162	122/7206	0.000423133604106
ko04626	Plant-pathogen interaction	9/1162	18/7206	0.000868859715519
ko05205	Proteoglycans in cancer	25/1162	271/7206	0.000994300950563
ko05169	Epstein-Barr virus infection	17/1162	206/7206	0.00103351954566
ko04146	Peroxisome	4/1162	89/7206	0.00120674367879
ko00480	Glutathione metabolism	1/1162	55/7206	0.00133210311162
ko04015	Rap1 signaling pathway	65/1162	278/7206	0.00148791201983
ko00590	Arachidonic acid metabolism	1/1162	52/7206	0.00198221701983
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1162	182/7206	0.00211705112487
ko05140	Leishmaniasis	3/1162	75/7206	0.00225734415877
ko04916	Melanogenesis	37/1162	142/7206	0.00247881758971
ko04923	Regulation of lipolysis in adipocytes	23/1162	77/7206	0.00256375809331
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1162	14/7206	0.00335371424008
ko00240	Pyrimidine metabolism	7/1162	110/7206	0.0036517969126
ko04964	Proximal tubule bicarbonate reclamation	11/1162	29/7206	0.00379173641677
ko03420	Nucleotide excision repair	1/1162	46/7206	0.00447575340854
ko04918	Thyroid hormone synthesis	24/1162	86/7206	0.00478885380646
ko04657	IL-17 signaling pathway	5/1162	87/7206	0.00502897154513
ko04270	Vascular smooth muscle contraction	38/1162	154/7206	0.00540247904808
ko05321	Inflammatory bowel disease (IBD)	2/1162	56/7206	0.00574293587992
ko04062	Chemokine signaling pathway	47/1162	201/7206	0.00631286578739
ko03022	Basal transcription factors	1/1162	44/7206	0.00669612586025
ko05144	Malaria	1/1162	45/7206	0.00685204252176
ko01524	Platinum drug resistance	4/1162	76/7206	0.00696831195577
ko05034	Alcoholism	54/1162	238/7206	0.00700634997151
ko04217	Necroptosis	16/1162	178/7206	0.00706943447525
ko05214	Glioma	22/1162	79/7206	0.00807226290853
ko04214	Apoptosis - fly	4/1162	72/7206	0.00970974705901
ko00310	Lysine degradation	4/1162	73/7206	0.00973876466901
ko05145	Toxoplasmosis	10/1162	126/7206	0.00982062338136
ko00140	Steroid hormone biosynthesis	1/1162	41/7206	0.0100374553753
ko04922	Glucagon signaling pathway	32/1162	128/7206	0.010237592989
ko04630	Jak-STAT signaling pathway	11/1162	132/7206	0.0117677776435
ko05231	Choline metabolism in cancer	33/1162	134/7206	0.0121121917378
ko04210	Apoptosis	17/1162	180/7206	0.01329938503
ko04622	RIG-I-like receptor signaling pathway	3/1162	62/7206	0.013684914536
ko05166	HTLV-I infection	32/1162	292/7206	0.0145125127656
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1162	40/7206	0.0154127325375
ko04658	Th1 and Th2 cell differentiation	7/1162	96/7206	0.0166498279156
ko00260	Glycine, serine and threonine metabolism	2/1162	48/7206	0.0177185758308
ko04973	Carbohydrate digestion and absorption	13/1162	42/7206	0.0177592048299
ko05016	Huntington's disease	22/1162	215/7206	0.0181139402238
ko00562	Inositol phosphate metabolism	23/1162	89/7206	0.0191176601614
ko04114	Oocyte meiosis	33/1162	139/7206	0.0191752988398
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1162	100/7206	0.0195561555674
ko05161	Hepatitis B	17/1162	173/7206	0.021038243309
ko00982	Drug metabolism - cytochrome P450	1/1162	37/7206	0.0226476110019
ko00630	Glyoxylate and dicarboxylate metabolism	1/1162	38/7206	0.0236434076922
ko03410	Base excision repair	1/1162	38/7206	0.0236434076922
ko03018	RNA degradation	6/1162	84/7206	0.0240231929689
ko04115	p53 signaling pathway	5/1162	74/7206	0.0252968818118
ko04930	Type II diabetes mellitus	15/1162	54/7206	0.0254390383127
ko04640	Hematopoietic cell lineage	4/1162	64/7206	0.0263346882644
ko05222	Small cell lung cancer	7/1162	89/7206	0.0295385211356
ko05131	Shigellosis	6/1162	82/7206	0.0328502587761
ko04668	TNF signaling pathway	11/1162	120/7206	0.033501088308
ko05418	Fluid shear stress and atherosclerosis	18/1162	173/7206	0.0364188212918
ko04330	Notch signaling pathway	4/1162	62/7206	0.0364422865969
ko00600	Sphingolipid metabolism	4/1162	63/7206	0.0369832628065
ko00280	Valine, leucine and isoleucine degradation	3/1162	54/7206	0.0384905797482
ko00071	Fatty acid degradation	2/1162	45/7206	0.0386640914016
ko05133	Pertussis	7/1162	87/7206	0.0392936655723
ko04350	TGF-beta signaling pathway	9/1162	103/7206	0.0420324161273
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1162	92/7206	0.0458841575659
ko05230	Central carbon metabolism in cancer	20/1162	81/7206	0.0465683638143
ko05217	Basal cell carcinoma	5/1162	68/7206	0.0467220772183
ko03320	PPAR signaling pathway	5/1162	69/7206	0.0469807872077