ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1099	423/7206	7.37312747805e-51
ko04724	Glutamatergic synapse	85/1099	152/7206	1.05356347801e-31
ko04713	Circadian entrainment	75/1099	136/7206	1.56394923249e-27
ko05033	Nicotine addiction	44/1099	56/7206	4.78402801603e-26
ko04728	Dopaminergic synapse	85/1099	185/7206	8.24395482725e-24
ko05032	Morphine addiction	62/1099	110/7206	1.27575775962e-23
ko04721	Synaptic vesicle cycle	50/1099	80/7206	4.69920622671e-22
ko04727	GABAergic synapse	59/1099	110/7206	4.67510782123e-21
ko04725	Cholinergic synapse	73/1099	160/7206	2.33023924317e-20
ko04726	Serotonergic synapse	63/1099	137/7206	6.22293342965e-18
ko04723	Retrograde endocannabinoid signaling	72/1099	175/7206	5.00501200076e-17
ko04911	Insulin secretion	55/1099	117/7206	2.47747658442e-16
ko04020	Calcium signaling pathway	93/1099	265/7206	3.45881548961e-16
ko04024	cAMP signaling pathway	96/1099	279/7206	5.04170136264e-16
ko04742	Taste transduction	37/1099	61/7206	5.08850408099e-16
ko04921	Oxytocin signaling pathway	77/1099	209/7206	6.66127322255e-15
ko05031	Amphetamine addiction	41/1099	91/7206	9.50503223282e-12
ko04720	Long-term potentiation	43/1099	99/7206	1.3320564248e-11
ko04970	Salivary secretion	40/1099	95/7206	2.21378167522e-10
ko04261	Adrenergic signaling in cardiomyocytes	66/1099	205/7206	6.45726807634e-10
ko03040	Spliceosome	1/1099	145/7206	1.35131962101e-09
ko04740	Olfactory transduction	33/1099	80/7206	1.57348828931e-08
ko04925	Aldosterone synthesis and secretion	39/1099	105/7206	2.63727038073e-08
ko04971	Gastric acid secretion	37/1099	98/7206	3.63658618789e-08
ko04360	Axon guidance	67/1099	233/7206	8.20077476837e-08
ko05203	Viral carcinogenesis	15/1099	277/7206	3.49982331045e-07
ko04730	Long-term depression	30/1099	78/7206	4.45934579203e-07
ko05322	Systemic lupus erythematosus	4/1099	151/7206	4.92479785137e-07
ko04744	Phototransduction	18/1099	36/7206	1.01932242534e-06
ko05030	Cocaine addiction	28/1099	73/7206	1.14950186574e-06
ko04972	Pancreatic secretion	37/1099	111/7206	1.57585458006e-06
ko03013	RNA transport	6/1099	166/7206	1.78107877014e-06
ko05164	Influenza A	6/1099	167/7206	1.8024080397e-06
ko04010	MAPK signaling pathway	81/1099	321/7206	2.19729627063e-06
ko04514	Cell adhesion molecules (CAMs)	41/1099	130/7206	2.85850766119e-06
ko04120	Ubiquitin mediated proteolysis	4/1099	138/7206	3.42080608031e-06
ko04022	cGMP-PKG signaling pathway	59/1099	216/7206	4.57488412336e-06
ko05168	Herpes simplex infection	8/1099	182/7206	4.99659405837e-06
ko04060	Cytokine-cytokine receptor interaction	9/1099	191/7206	5.38934628131e-06
ko04966	Collecting duct acid secretion	14/1099	26/7206	5.40326995183e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1099	74/7206	5.45524185479e-06
ko04540	Gap junction	39/1099	128/7206	9.91708717861e-06
ko04745	Phototransduction - fly	17/1099	38/7206	1.37336511441e-05
ko04070	Phosphatidylinositol signaling system	35/1099	112/7206	1.52811395262e-05
ko04621	NOD-like receptor signaling pathway	7/1099	157/7206	2.54898294156e-05
ko04141	Protein processing in endoplasmic reticulum	10/1099	184/7206	4.23689660928e-05
ko04924	Renin secretion	28/1099	86/7206	5.2674658228e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1099	122/7206	5.81999729114e-05
ko04014	Ras signaling pathway	67/1099	279/7206	8.49198905566e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1099	79/7206	9.45645794791e-05
ko04260	Cardiac muscle contraction	30/1099	98/7206	9.8680109545e-05
ko04110	Cell cycle	7/1099	145/7206	0.000101737966369
ko05110	Vibrio cholerae infection	22/1099	63/7206	0.000114484772243
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1099	59/7206	0.000145729743152
ko04072	Phospholipase D signaling pathway	50/1099	197/7206	0.000174820810475
ko05169	Epstein-Barr virus infection	14/1099	206/7206	0.000250918453677
ko03008	Ribosome biogenesis in eukaryotes	2/1099	79/7206	0.000409419035553
ko04612	Antigen processing and presentation	2/1099	77/7206	0.000617043973158
ko04964	Proximal tubule bicarbonate reclamation	12/1099	29/7206	0.00062028132439
ko04976	Bile secretion	24/1099	80/7206	0.000783631818632
ko04064	NF-kappa B signaling pathway	4/1099	96/7206	0.000886490098778
ko05162	Measles	7/1099	120/7206	0.00198656134164
ko04610	Complement and coagulation cascades	3/1099	79/7206	0.00235021257118
ko04146	Peroxisome	4/1099	89/7206	0.00259964779234
ko04626	Plant-pathogen interaction	8/1099	18/7206	0.00298924063513
ko04916	Melanogenesis	35/1099	142/7206	0.00298928632449
ko05414	Dilated cardiomyopathy	29/1099	112/7206	0.00321571293483
ko05140	Leishmaniasis	3/1099	75/7206	0.00330823447003
ko01524	Platinum drug resistance	3/1099	76/7206	0.00335461499106
ko05205	Proteoglycans in cancer	25/1099	271/7206	0.00430191704529
ko04630	Jak-STAT signaling pathway	9/1099	132/7206	0.00464339346862
ko05166	HTLV-I infection	28/1099	292/7206	0.00465168778665
ko04371	Apelin signaling pathway	41/1099	177/7206	0.00557361540595
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1099	182/7206	0.00634088850166
ko04270	Vascular smooth muscle contraction	36/1099	154/7206	0.00644901067013
ko04915	Estrogen signaling pathway	32/1099	131/7206	0.00645094420267
ko03420	Nucleotide excision repair	1/1099	46/7206	0.00697389489508
ko00240	Pyrimidine metabolism	7/1099	110/7206	0.0069876725207
ko04912	GnRH signaling pathway	30/1099	122/7206	0.00707148930996
ko05161	Hepatitis B	14/1099	173/7206	0.00707404671224
ko04217	Necroptosis	15/1099	178/7206	0.00813668662027
ko05145	Toxoplasmosis	9/1099	126/7206	0.00828070087208
ko03022	Basal transcription factors	1/1099	44/7206	0.0104201847568
ko04015	Rap1 signaling pathway	58/1099	278/7206	0.0104930271416
ko05144	Malaria	1/1099	45/7206	0.010705504439
ko00071	Fatty acid degradation	1/1099	45/7206	0.010705504439
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1099	14/7206	0.0124104597155
ko00280	Valine, leucine and isoleucine degradation	2/1099	54/7206	0.0126374162876
ko00590	Arachidonic acid metabolism	2/1099	52/7206	0.0184832956566
ko00330	Arginine and proline metabolism	3/1099	61/7206	0.0194178213162
ko04330	Notch signaling pathway	3/1099	62/7206	0.0196241268577
ko04622	RIG-I-like receptor signaling pathway	3/1099	62/7206	0.0196241268577
ko04214	Apoptosis - fly	4/1099	72/7206	0.0197594006368
ko04930	Type II diabetes mellitus	15/1099	54/7206	0.0201531702523
ko00310	Lysine degradation	4/1099	73/7206	0.0202924017336
ko03410	Base excision repair	1/1099	38/7206	0.0230385563361
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1099	100/7206	0.0236986161419
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1099	40/7206	0.0241407140813
ko05418	Fluid shear stress and atherosclerosis	16/1099	173/7206	0.0243466690045
ko04657	IL-17 signaling pathway	6/1099	87/7206	0.0245062918647
ko05133	Pertussis	6/1099	87/7206	0.0245062918647
ko05222	Small cell lung cancer	6/1099	89/7206	0.0247928665433
ko04923	Regulation of lipolysis in adipocytes	19/1099	77/7206	0.0256555278994
ko04960	Aldosterone-regulated sodium reabsorption	12/1099	41/7206	0.0256657320267
ko00260	Glycine, serine and threonine metabolism	2/1099	48/7206	0.0263549594004
ko03320	PPAR signaling pathway	4/1099	69/7206	0.0272846549384
ko04973	Carbohydrate digestion and absorption	12/1099	42/7206	0.0278568633654
ko04658	Th1 and Th2 cell differentiation	7/1099	96/7206	0.0307386907492
ko05215	Prostate cancer	9/1099	111/7206	0.0329423227113
ko04975	Fat digestion and absorption	1/1099	35/7206	0.0342479942604
ko00500	Starch and sucrose metabolism	1/1099	35/7206	0.0342479942604
ko00982	Drug metabolism - cytochrome P450	1/1099	37/7206	0.03533259684
ko00562	Inositol phosphate metabolism	21/1099	89/7206	0.036494073223
ko00480	Glutathione metabolism	3/1099	55/7206	0.0384429544934
ko05321	Inflammatory bowel disease (IBD)	3/1099	56/7206	0.0385871775017
ko05214	Glioma	19/1099	79/7206	0.0391086390794
ko04668	TNF signaling pathway	10/1099	120/7206	0.0392057940793
ko05016	Huntington's disease	22/1099	215/7206	0.0424471698889
ko05131	Shigellosis	6/1099	82/7206	0.0440468108651
ko03018	RNA degradation	6/1099	84/7206	0.0452471658719
ko04210	Apoptosis	18/1099	180/7206	0.0461129493482
ko04071	Sphingolipid signaling pathway	34/1099	162/7206	0.0461857679095
ko04918	Thyroid hormone synthesis	20/1099	86/7206	0.0483134556716
ko04620	Toll-like receptor signaling pathway	8/1099	100/7206	0.0483905106259
ko04115	p53 signaling pathway	5/1099	74/7206	0.048946539305