ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1098	423/7206	6.34645762614e-51
ko04724	Glutamatergic synapse	94/1098	152/7206	3.83813412682e-40
ko05033	Nicotine addiction	50/1098	56/7206	6.83805968292e-35
ko05032	Morphine addiction	71/1098	110/7206	3.1290860188e-32
ko04727	GABAergic synapse	69/1098	110/7206	3.32921252172e-30
ko04713	Circadian entrainment	76/1098	136/7206	1.9885975338e-28
ko04728	Dopaminergic synapse	88/1098	185/7206	5.35383759395e-26
ko04725	Cholinergic synapse	80/1098	160/7206	1.57508023936e-25
ko04723	Retrograde endocannabinoid signaling	79/1098	175/7206	1.28469613862e-21
ko04024	cAMP signaling pathway	103/1098	279/7206	9.24549714194e-20
ko04726	Serotonergic synapse	62/1098	137/7206	2.92625716526e-17
ko04911	Insulin secretion	56/1098	117/7206	4.50324067755e-17
ko04020	Calcium signaling pathway	93/1098	265/7206	3.3043467038e-16
ko04921	Oxytocin signaling pathway	79/1098	209/7206	4.67220861529e-16
ko04742	Taste transduction	36/1098	61/7206	4.22146291132e-15
ko05031	Amphetamine addiction	45/1098	91/7206	1.25893863005e-14
ko04721	Synaptic vesicle cycle	41/1098	80/7206	4.03377725389e-14
ko04720	Long-term potentiation	45/1098	99/7206	5.9638840002e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1098	205/7206	7.79319116109e-13
ko05030	Cocaine addiction	35/1098	73/7206	3.54578448663e-11
ko04970	Salivary secretion	40/1098	95/7206	2.15188145341e-10
ko04744	Phototransduction	22/1098	36/7206	3.85912606321e-10
ko04925	Aldosterone synthesis and secretion	42/1098	105/7206	5.25968359364e-10
ko03040	Spliceosome	1/1098	145/7206	1.35214465149e-09
ko04971	Gastric acid secretion	39/1098	98/7206	2.61217638813e-09
ko04010	MAPK signaling pathway	88/1098	321/7206	1.02927705555e-08
ko04360	Axon guidance	68/1098	233/7206	4.22068361178e-08
ko05203	Viral carcinogenesis	14/1098	277/7206	8.832747829e-08
ko04972	Pancreatic secretion	39/1098	111/7206	1.55773707122e-07
ko04022	cGMP-PKG signaling pathway	62/1098	216/7206	3.55954818939e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1098	74/7206	4.26624813787e-07
ko04072	Phospholipase D signaling pathway	57/1098	197/7206	8.83740574774e-07
ko04060	Cytokine-cytokine receptor interaction	8/1098	191/7206	1.7660441065e-06
ko05322	Systemic lupus erythematosus	5/1098	151/7206	3.03858971726e-06
ko05168	Herpes simplex infection	8/1098	182/7206	4.98334944149e-06
ko04730	Long-term depression	28/1098	78/7206	7.52406605958e-06
ko03013	RNA transport	7/1098	166/7206	8.93271535478e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1098	79/7206	2.34898971705e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1098	59/7206	2.66380521558e-05
ko04540	Gap junction	38/1098	128/7206	2.89642485971e-05
ko04740	Olfactory transduction	27/1098	80/7206	2.95162146216e-05
ko04141	Protein processing in endoplasmic reticulum	10/1098	184/7206	4.24177348005e-05
ko05414	Dilated cardiomyopathy	34/1098	112/7206	4.71687183051e-05
ko04070	Phosphatidylinositol signaling system	34/1098	112/7206	4.71687183051e-05
ko04915	Estrogen signaling pathway	38/1098	131/7206	6.24139591802e-05
ko04014	Ras signaling pathway	67/1098	279/7206	8.38160120584e-05
ko04371	Apelin signaling pathway	46/1098	177/7206	0.000177844852538
ko05164	Influenza A	10/1098	167/7206	0.000289512435504
ko04621	NOD-like receptor signaling pathway	9/1098	157/7206	0.000291476130103
ko04750	Inflammatory mediator regulation of TRP channels	34/1098	122/7206	0.000303801920912
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1098	14/7206	0.000360250581245
ko04924	Renin secretion	26/1098	86/7206	0.000386756747937
ko03008	Ribosome biogenesis in eukaryotes	2/1098	79/7206	0.000409315645834
ko04015	Rap1 signaling pathway	64/1098	278/7206	0.000454732077518
ko04514	Cell adhesion molecules (CAMs)	35/1098	130/7206	0.000489982020946
ko04260	Cardiac muscle contraction	28/1098	98/7206	0.000596389337041
ko04612	Antigen processing and presentation	2/1098	77/7206	0.000615985717187
ko04640	Hematopoietic cell lineage	1/1098	64/7206	0.000635914803005
ko04912	GnRH signaling pathway	33/1098	122/7206	0.00079860829014
ko04745	Phototransduction - fly	14/1098	38/7206	0.000889688297011
ko05205	Proteoglycans in cancer	23/1098	271/7206	0.00101037759405
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1098	182/7206	0.00113183827089
ko04110	Cell cycle	9/1098	145/7206	0.00143879266858
ko05169	Epstein-Barr virus infection	16/1098	206/7206	0.00155267345775
ko00240	Pyrimidine metabolism	6/1098	110/7206	0.00198519526758
ko00520	Amino sugar and nucleotide sugar metabolism	1/1098	55/7206	0.00208644318342
ko05321	Inflammatory bowel disease (IBD)	1/1098	56/7206	0.00216061561154
ko04923	Regulation of lipolysis in adipocytes	22/1098	77/7206	0.00225895096256
ko00515	Mannose type O-glycan biosynthesis	10/1098	25/7206	0.0023704477426
ko04976	Bile secretion	23/1098	80/7206	0.0024450842307
ko04120	Ubiquitin mediated proteolysis	9/1098	138/7206	0.0025694590847
ko04916	Melanogenesis	35/1098	142/7206	0.00296865210465
ko05016	Huntington's disease	18/1098	215/7206	0.00364444199148
ko04064	NF-kappa B signaling pathway	5/1098	96/7206	0.00380622621442
ko04142	Lysosome	11/1098	151/7206	0.00404852814778
ko05034	Alcoholism	52/1098	238/7206	0.00573861509818
ko04918	Thyroid hormone synthesis	23/1098	86/7206	0.00584033858323
ko00330	Arginine and proline metabolism	2/1098	61/7206	0.00619889203907
ko04270	Vascular smooth muscle contraction	36/1098	154/7206	0.00640204376898
ko03420	Nucleotide excision repair	1/1098	46/7206	0.00698111892748
ko00260	Glycine, serine and threonine metabolism	1/1098	48/7206	0.00726601651523
ko04146	Peroxisome	5/1098	89/7206	0.00728057531903
ko04217	Necroptosis	15/1098	178/7206	0.00814218282069
ko00513	Various types of N-glycan biosynthesis	13/1098	42/7206	0.00858354716356
ko03022	Basal transcription factors	1/1098	44/7206	0.0104213516986
ko00071	Fatty acid degradation	1/1098	45/7206	0.0106938216496
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1098	100/7206	0.0108029323229
ko04062	Chemokine signaling pathway	44/1098	201/7206	0.0123661548727
ko04350	TGF-beta signaling pathway	7/1098	103/7206	0.012659224695
ko00480	Glutathione metabolism	2/1098	55/7206	0.0128482193804
ko05110	Vibrio cholerae infection	17/1098	63/7206	0.0133896827049
ko03018	RNA degradation	5/1098	84/7206	0.0138842109774
ko04115	p53 signaling pathway	4/1098	74/7206	0.0140590149251
ko05140	Leishmaniasis	4/1098	75/7206	0.014248400699
ko05162	Measles	9/1098	120/7206	0.0145636288007
ko04114	Oocyte meiosis	32/1098	139/7206	0.0163622832927
ko00190	Oxidative phosphorylation	10/1098	127/7206	0.0174972015496
ko05145	Toxoplasmosis	10/1098	126/7206	0.0175121928809
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1098	15/7206	0.0179868462254
ko04622	RIG-I-like receptor signaling pathway	3/1098	62/7206	0.0196124881466
ko04214	Apoptosis - fly	4/1098	72/7206	0.0197449671119
ko04930	Type II diabetes mellitus	15/1098	54/7206	0.0201018428518
ko04670	Leukocyte transendothelial migration	13/1098	151/7206	0.0214817894658
ko00630	Glyoxylate and dicarboxylate metabolism	1/1098	38/7206	0.0230526672388
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1098	40/7206	0.0241089594363
ko05161	Hepatitis B	16/1098	173/7206	0.0243555375021
ko04973	Carbohydrate digestion and absorption	12/1098	42/7206	0.0277731258621
ko05231	Choline metabolism in cancer	30/1098	134/7206	0.0280012716855
ko05202	Transcriptional misregulation in cancer	18/1098	188/7206	0.0301818736611
ko04964	Proximal tubule bicarbonate reclamation	9/1098	29/7206	0.0324888880014
ko00982	Drug metabolism - cytochrome P450	1/1098	37/7206	0.0352991773516
ko04711	Circadian rhythm - fly	5/1098	13/7206	0.0361751169501
ko00620	Pyruvate metabolism	2/1098	46/7206	0.0379855728551
ko04962	Vasopressin-regulated water reabsorption	15/1098	58/7206	0.040686346679
ko04137	Mitophagy - animal	6/1098	82/7206	0.0440543327308
ko04722	Neurotrophin signaling pathway	34/1098	160/7206	0.0442425044079
ko00510	N-Glycan biosynthesis	13/1098	50/7206	0.0457179381902
ko04071	Sphingolipid signaling pathway	34/1098	162/7206	0.0460305823383
ko04210	Apoptosis	18/1098	180/7206	0.0461398083934
ko00310	Lysine degradation	5/1098	73/7206	0.0480765549627
ko04213	Longevity regulating pathway - multiple species	20/1098	86/7206	0.0481752197718
ko04960	Aldosterone-regulated sodium reabsorption	11/1098	41/7206	0.0482268621273
ko04630	Jak-STAT signaling pathway	12/1098	132/7206	0.0498257072127