ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	210/1233	423/7206	1.7737996921e-57
ko04724	Glutamatergic synapse	95/1233	152/7206	1.06883947488e-36
ko05033	Nicotine addiction	50/1233	56/7206	2.2422650525e-32
ko05032	Morphine addiction	72/1233	110/7206	6.82051326194e-30
ko04727	GABAergic synapse	71/1233	110/7206	6.46154227277e-29
ko04713	Circadian entrainment	79/1233	136/7206	1.52268835354e-27
ko04721	Synaptic vesicle cycle	52/1233	80/7206	1.12105078561e-21
ko04728	Dopaminergic synapse	87/1233	185/7206	1.16771808906e-21
ko04725	Cholinergic synapse	79/1233	160/7206	2.02861843126e-21
ko04024	cAMP signaling pathway	113/1233	279/7206	3.59020036645e-21
ko04020	Calcium signaling pathway	106/1233	265/7206	1.88412783161e-19
ko04723	Retrograde endocannabinoid signaling	80/1233	175/7206	4.72644248989e-19
ko04744	Phototransduction	29/1233	36/7206	1.06905773693e-16
ko04911	Insulin secretion	58/1233	117/7206	3.95144926084e-16
ko04726	Serotonergic synapse	64/1233	137/7206	4.83924853175e-16
ko04921	Oxytocin signaling pathway	83/1233	209/7206	3.33809438939e-15
ko04742	Taste transduction	36/1233	61/7206	1.70579124333e-13
ko04720	Long-term potentiation	48/1233	99/7206	4.20945850878e-13
ko05031	Amphetamine addiction	45/1233	91/7206	9.46269583782e-13
ko03040	Spliceosome	1/1233	145/7206	7.25152522695e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1233	205/7206	9.24261358957e-11
ko04970	Salivary secretion	43/1233	95/7206	1.22080691767e-10
ko04740	Olfactory transduction	38/1233	80/7206	2.58556402146e-10
ko03010	Ribosome	1/1233	129/7206	9.57416762426e-10
ko04925	Aldosterone synthesis and secretion	42/1233	105/7206	2.15208515357e-08
ko05168	Herpes simplex infection	7/1233	182/7206	4.04703988305e-08
ko04060	Cytokine-cytokine receptor interaction	8/1233	191/7206	4.99108533907e-08
ko05203	Viral carcinogenesis	17/1233	277/7206	5.37609930827e-08
ko04971	Gastric acid secretion	39/1233	98/7206	8.16325231855e-08
ko05030	Cocaine addiction	31/1233	73/7206	2.87267938011e-07
ko04022	cGMP-PKG signaling pathway	67/1233	216/7206	3.1490094838e-07
ko03013	RNA transport	7/1233	166/7206	5.72863760339e-07
ko04070	Phosphatidylinositol signaling system	41/1233	112/7206	6.86290700077e-07
ko05322	Systemic lupus erythematosus	6/1233	151/7206	9.754632473e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1233	74/7206	2.3304421359e-06
ko04360	Axon guidance	67/1233	233/7206	7.74586921069e-06
ko04621	NOD-like receptor signaling pathway	8/1233	157/7206	8.14837851775e-06
ko04745	Phototransduction - fly	18/1233	38/7206	1.48392660373e-05
ko04924	Renin secretion	31/1233	86/7206	1.91722269946e-05
ko04966	Collecting duct acid secretion	14/1233	26/7206	2.14119719408e-05
ko04730	Long-term depression	29/1233	78/7206	2.34335300945e-05
ko05164	Influenza A	10/1233	167/7206	2.56705240198e-05
ko04141	Protein processing in endoplasmic reticulum	12/1233	184/7206	2.63768627463e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1233	79/7206	2.76609305107e-05
ko04072	Phospholipase D signaling pathway	57/1233	197/7206	3.03043471398e-05
ko05414	Dilated cardiomyopathy	37/1233	112/7206	3.60897722907e-05
ko04540	Gap junction	41/1233	128/7206	4.09601688345e-05
ko04110	Cell cycle	8/1233	145/7206	4.69753622603e-05
ko04972	Pancreatic secretion	36/1233	111/7206	6.44642808059e-05
ko04612	Antigen processing and presentation	2/1233	77/7206	0.00010738314738
ko05169	Epstein-Barr virus infection	16/1233	206/7206	0.000108706965796
ko04610	Complement and coagulation cascades	2/1233	79/7206	0.000113366040439
ko03008	Ribosome biogenesis in eukaryotes	2/1233	79/7206	0.000113366040439
ko04750	Inflammatory mediator regulation of TRP channels	38/1233	122/7206	0.000132361804219
ko04514	Cell adhesion molecules (CAMs)	40/1233	130/7206	0.000132400948432
ko04120	Ubiquitin mediated proteolysis	8/1233	138/7206	0.000132576413574
ko04371	Apelin signaling pathway	50/1233	177/7206	0.000167830223379
ko04923	Regulation of lipolysis in adipocytes	27/1233	77/7206	0.000174705493093
ko04010	MAPK signaling pathway	81/1233	321/7206	0.00018632538491
ko04976	Bile secretion	27/1233	80/7206	0.000259288666494
ko05110	Vibrio cholerae infection	23/1233	63/7206	0.000265357083495
ko04260	Cardiac muscle contraction	31/1233	98/7206	0.000366218740292
ko04915	Estrogen signaling pathway	38/1233	131/7206	0.000610873330469
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1233	59/7206	0.00067053482819
ko04922	Glucagon signaling pathway	37/1233	128/7206	0.000808529126632
ko00520	Amino sugar and nucleotide sugar metabolism	1/1233	55/7206	0.000859052113142
ko00480	Glutathione metabolism	1/1233	55/7206	0.000859052113142
ko04064	NF-kappa B signaling pathway	5/1233	96/7206	0.000881541161488
ko05205	Proteoglycans in cancer	27/1233	271/7206	0.000958954696055
ko05140	Leishmaniasis	3/1233	75/7206	0.000989847442623
ko04014	Ras signaling pathway	69/1233	279/7206	0.00111346473014
ko05162	Measles	8/1233	120/7206	0.0013035909225
ko04626	Plant-pathogen interaction	9/1233	18/7206	0.00135360926076
ko04214	Apoptosis - fly	3/1233	72/7206	0.00142880755547
ko04330	Notch signaling pathway	2/1233	62/7206	0.00180755858079
ko05161	Hepatitis B	15/1233	173/7206	0.00202264029518
ko04657	IL-17 signaling pathway	5/1233	87/7206	0.00243587445611
ko03420	Nucleotide excision repair	1/1233	46/7206	0.00281801669935
ko04912	GnRH signaling pathway	34/1233	122/7206	0.00327675045016
ko05166	HTLV-I infection	32/1233	292/7206	0.00329131188937
ko05321	Inflammatory bowel disease (IBD)	2/1233	56/7206	0.00375213283672
ko00562	Inositol phosphate metabolism	26/1233	89/7206	0.00421249823848
ko03022	Basal transcription factors	1/1233	44/7206	0.00424895176302
ko05144	Malaria	1/1233	45/7206	0.00437422660431
ko00240	Pyrimidine metabolism	8/1233	110/7206	0.00457014771177
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1233	14/7206	0.00474472881989
ko04622	RIG-I-like receptor signaling pathway	3/1233	62/7206	0.00622520690091
ko04146	Peroxisome	6/1233	89/7206	0.00662428328377
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1233	100/7206	0.00685894883746
ko04350	TGF-beta signaling pathway	8/1233	103/7206	0.00818600827965
ko04973	Carbohydrate digestion and absorption	14/1233	42/7206	0.0114464113886
ko05145	Toxoplasmosis	11/1233	126/7206	0.0115703680078
ko03018	RNA degradation	6/1233	84/7206	0.0124928063995
ko04710	Circadian rhythm	14/1233	43/7206	0.0128973713755
ko04115	p53 signaling pathway	5/1233	74/7206	0.0129254517531
ko04062	Chemokine signaling pathway	48/1233	201/7206	0.0131847396491
ko04630	Jak-STAT signaling pathway	12/1233	132/7206	0.0136521846241
ko05231	Choline metabolism in cancer	34/1233	134/7206	0.0145213022533
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1233	182/7206	0.0162265358211
ko05016	Huntington's disease	24/1233	215/7206	0.0167436077601
ko05131	Shigellosis	6/1233	82/7206	0.0172127319952
ko05418	Fluid shear stress and atherosclerosis	18/1233	173/7206	0.0182295399482
ko04668	TNF signaling pathway	11/1233	120/7206	0.0194957736246
ko04658	Th1 and Th2 cell differentiation	8/1233	96/7206	0.0197285704467
ko04217	Necroptosis	19/1233	178/7206	0.0201004909014
ko05133	Pertussis	7/1233	87/7206	0.021396204615
ko00860	Porphyrin and chlorophyll metabolism	1/1233	34/7206	0.0216117428674
ko04964	Proximal tubule bicarbonate reclamation	10/1233	29/7206	0.0224173468284
ko03320	PPAR signaling pathway	5/1233	69/7206	0.0244784029872
ko04930	Type II diabetes mellitus	16/1233	54/7206	0.0271585873826
ko04114	Oocyte meiosis	34/1233	139/7206	0.0298308239626
ko05202	Transcriptional misregulation in cancer	21/1233	188/7206	0.0303003646827
ko01524	Platinum drug resistance	6/1233	76/7206	0.0311840239307
ko05217	Basal cell carcinoma	5/1233	68/7206	0.0338574649394
ko05214	Glioma	21/1233	79/7206	0.034022633213
ko04015	Rap1 signaling pathway	61/1233	278/7206	0.0343907375318
ko04210	Apoptosis	20/1233	180/7206	0.0346110850858
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1233	40/7206	0.0359611222678
ko04510	Focal adhesion	29/1233	240/7206	0.0361462439736
ko04270	Vascular smooth muscle contraction	36/1233	154/7206	0.0400888290246
ko05215	Prostate cancer	11/1233	111/7206	0.0418781632561
ko05206	MicroRNAs in cancer	20/1233	177/7206	0.0425472550355
ko04213	Longevity regulating pathway - multiple species	22/1233	86/7206	0.0430558440132
ko04918	Thyroid hormone synthesis	22/1233	86/7206	0.0430558440132
ko04640	Hematopoietic cell lineage	5/1233	64/7206	0.0455086867566
ko05320	Autoimmune thyroid disease	1/1233	29/7206	0.0481564148871