ko pathway ratio_in_study ratio_in_pop p_value ko04744 Phototransduction 25/517 36/7206 4.07421431027e-21 ko05032 Morphine addiction 30/517 110/7206 7.67207797987e-11 ko04713 Circadian entrainment 33/517 136/7206 2.5626809038e-10 ko04727 GABAergic synapse 28/517 110/7206 1.88216944823e-09 ko05033 Nicotine addiction 19/517 56/7206 4.57202607393e-09 ko04724 Glutamatergic synapse 32/517 152/7206 2.0702306768e-08 ko04725 Cholinergic synapse 33/517 160/7206 2.11294332668e-08 ko04020 Calcium signaling pathway 43/517 265/7206 3.00374713148e-07 ko04726 Serotonergic synapse 28/517 137/7206 3.10053228886e-07 ko04080 Neuroactive ligand-receptor interaction 57/517 423/7206 2.30684299369e-06 ko04740 Olfactory transduction 19/517 80/7206 2.45028782229e-06 ko04911 Insulin secretion 23/517 117/7206 7.10422668473e-06 ko04723 Retrograde endocannabinoid signaling 29/517 175/7206 1.799312328e-05 ko04024 cAMP signaling pathway 40/517 279/7206 2.37960098174e-05 ko04921 Oxytocin signaling pathway 32/517 209/7206 3.35133519558e-05 ko04742 Taste transduction 14/517 61/7206 7.78846062447e-05 ko03013 RNA transport 1/517 166/7206 9.66973271334e-05 ko04970 Salivary secretion 18/517 95/7206 0.000115816717108 ko05203 Viral carcinogenesis 6/517 277/7206 0.000308840807955 ko04974 Protein digestion and absorption 17/517 96/7206 0.00041356726065 ko03040 Spliceosome 1/517 145/7206 0.000464960808226 ko04721 Synaptic vesicle cycle 15/517 80/7206 0.000476344120263 ko04971 Gastric acid secretion 17/517 98/7206 0.000530593544408 ko00830 Retinol metabolism 10/517 42/7206 0.000599681726156 ko04710 Circadian rhythm 10/517 43/7206 0.000732225445291 ko04371 Apelin signaling pathway 25/517 177/7206 0.00096992878851 ko04972 Pancreatic secretion 18/517 111/7206 0.00108755376735 ko05168 Herpes simplex infection 3/517 182/7206 0.00118937972325 ko03010 Ribosome 1/517 129/7206 0.00149166280065 ko00230 Purine metabolism 26/517 194/7206 0.00169637954193 ko05322 Systemic lupus erythematosus 2/517 151/7206 0.00202757666615 ko04728 Dopaminergic synapse 25/517 185/7206 0.00205842586917 ko05164 Influenza A 3/517 167/7206 0.00341819818753 ko05166 HTLV-I infection 9/517 292/7206 0.00356006160465 ko05169 Epstein-Barr virus infection 5/517 206/7206 0.00383517404883 ko05030 Cocaine addiction 12/517 73/7206 0.00534351631953 ko00360 Phenylalanine metabolism 5/517 17/7206 0.00559208744991 ko04380 Osteoclast differentiation 2/517 134/7206 0.00593375606989 ko04976 Bile secretion 13/517 80/7206 0.00672487974536 ko05161 Hepatitis B 4/517 173/7206 0.00703370506655 ko04261 Adrenergic signaling in cardiomyocytes 25/517 205/7206 0.00841161209245 ko04620 Toll-like receptor signaling pathway 1/517 100/7206 0.0097192696226 ko04022 cGMP-PKG signaling pathway 26/517 216/7206 0.0100949654656 ko04270 Vascular smooth muscle contraction 20/517 154/7206 0.0102562113009 ko04925 Aldosterone synthesis and secretion 15/517 105/7206 0.0111211629908 ko05162 Measles 2/517 120/7206 0.0117312653125 ko04668 TNF signaling pathway 2/517 120/7206 0.0117312653125 ko05031 Amphetamine addiction 13/517 91/7206 0.0135990954505 ko04658 Th1 and Th2 cell differentiation 1/517 96/7206 0.0145426541266 ko04064 NF-kappa B signaling pathway 1/517 96/7206 0.0145426541266 ko04260 Cardiac muscle contraction 14/517 98/7206 0.0153457244826 ko04745 Phototransduction - fly 7/517 38/7206 0.0168949749493 ko04120 Ubiquitin mediated proteolysis 3/517 138/7206 0.0181773783661 ko04662 B cell receptor signaling pathway 1/517 88/7206 0.0203362577249 ko05205 Proteoglycans in cancer 10/517 271/7206 0.0218809596595 ko04978 Mineral absorption 7/517 40/7206 0.0220644837836 ko04060 Cytokine-cytokine receptor interaction 6/517 191/7206 0.0229040874267 ko04960 Aldosterone-regulated sodium reabsorption 7/517 41/7206 0.025020528772 ko04062 Chemokine signaling pathway 23/517 201/7206 0.0252775482807 ko05131 Shigellosis 1/517 82/7206 0.029379178858 ko05212 Pancreatic cancer 1/517 83/7206 0.0296615854946 ko00340 Histidine metabolism 5/517 25/7206 0.0298861177062 ko05202 Transcriptional misregulation in cancer 6/517 188/7206 0.0305455162475 ko04350 TGF-beta signaling pathway 2/517 103/7206 0.0330898594419 ko04110 Cell cycle 4/517 145/7206 0.0336602532566 ko04660 T cell receptor signaling pathway 3/517 124/7206 0.0341498012663 ko04514 Cell adhesion molecules (CAMs) 16/517 130/7206 0.0367239950764 ko04141 Protein processing in endoplasmic reticulum 6/517 184/7206 0.0409257592433 ko05140 Leishmaniasis 1/517 75/7206 0.0422727983353 ko04664 Fc epsilon RI signaling pathway 1/517 77/7206 0.0427140713157 ko04145 Phagosome 5/517 162/7206 0.0435031129531 ko05211 Renal cell carcinoma 2/517 96/7206 0.046359487277 ko04650 Natural killer cell mediated cytotoxicity 2/517 97/7206 0.0464030571674 ko05132 Salmonella infection 2/517 98/7206 0.0466208515602 ko05100 Bacterial invasion of epithelial cells 2/517 99/7206 0.0470120790059