ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 68/472 145/7206 7.2339701655e-43 ko03013 RNA transport 56/472 166/7206 2.5005649581e-26 ko03008 Ribosome biogenesis in eukaryotes 37/472 79/7206 1.46026988171e-23 ko04110 Cell cycle 48/472 145/7206 2.95289854786e-22 ko03030 DNA replication 24/472 38/7206 9.08243467184e-20 ko04111 Cell cycle - yeast 34/472 90/7206 4.13564136494e-18 ko03440 Homologous recombination 22/472 41/7206 4.30757398853e-16 ko03460 Fanconi anemia pathway 22/472 51/7206 1.481300371e-13 ko03430 Mismatch repair 15/472 22/7206 1.57613017525e-13 ko00240 Pyrimidine metabolism 31/472 110/7206 1.3086118846e-12 ko04113 Meiosis - yeast 22/472 70/7206 2.51897991429e-10 ko03420 Nucleotide excision repair 17/472 46/7206 1.68016458325e-09 ko03410 Base excision repair 15/472 38/7206 5.36138721365e-09 ko03020 RNA polymerase 13/472 29/7206 8.94100899005e-09 ko04144 Endocytosis 2/472 342/7206 3.21684786694e-08 ko03015 mRNA surveillance pathway 22/472 93/7206 8.58060928283e-08 ko04024 cAMP signaling pathway 1/472 279/7206 1.7691106965e-07 ko03018 RNA degradation 20/472 84/7206 2.98375930772e-07 ko04510 Focal adhesion 1/472 240/7206 1.92250833494e-06 ko04062 Chemokine signaling pathway 1/472 201/7206 3.15018671443e-05 ko04810 Regulation of actin cytoskeleton 3/472 264/7206 3.47201851336e-05 ko04530 Tight junction 2/472 228/7206 5.31294408862e-05 ko00230 Purine metabolism 28/472 194/7206 8.13502927937e-05 ko04728 Dopaminergic synapse 1/472 185/7206 0.000107081221353 ko04723 Retrograde endocannabinoid signaling 1/472 175/7206 0.000146757263035 ko04015 Rap1 signaling pathway 5/472 278/7206 0.000286854277541 ko04071 Sphingolipid signaling pathway 1/472 162/7206 0.000317356508286 ko05166 HTLV-I infection 35/472 292/7206 0.000407214629153 ko04151 PI3K-Akt signaling pathway 10/472 390/7206 0.000453989544132 ko04010 MAPK signaling pathway 7/472 321/7206 0.000457848642896 ko05152 Tuberculosis 2/472 187/7206 0.000471969918175 ko04725 Cholinergic synapse 1/472 160/7206 0.000491899694924 ko04142 Lysosome 1/472 151/7206 0.000689052768267 ko04724 Glutamatergic synapse 1/472 152/7206 0.000696344213069 ko04371 Apelin signaling pathway 2/472 177/7206 0.000996854792364 ko04014 Ras signaling pathway 6/472 279/7206 0.00115688241068 ko04910 Insulin signaling pathway 2/472 172/7206 0.0014580172326 ko04931 Insulin resistance 1/472 137/7206 0.00147457449442 ko04726 Serotonergic synapse 1/472 137/7206 0.00147457449442 ko05418 Fluid shear stress and atherosclerosis 2/472 173/7206 0.00148645835749 ko04145 Phagosome 2/472 162/7206 0.00202507763531 ko04915 Estrogen signaling pathway 1/472 131/7206 0.00215737963116 ko04713 Circadian entrainment 1/472 136/7206 0.0022822839285 ko04360 Axon guidance 5/472 233/7206 0.00284179013369 ko05145 Toxoplasmosis 1/472 126/7206 0.00315595151448 ko04540 Gap junction 1/472 128/7206 0.00321347488877 ko04914 Progesterone-mediated oocyte maturation 15/472 104/7206 0.00382093286737 ko05217 Basal cell carcinoma 11/472 68/7206 0.0043160029098 ko04912 GnRH signaling pathway 1/472 122/7206 0.00469500212272 ko04666 Fc gamma R-mediated phagocytosis 1/472 122/7206 0.00469500212272 ko04066 HIF-1 signaling pathway 1/472 123/7206 0.00477497401918 ko04114 Oocyte meiosis 18/472 139/7206 0.00484545004126 ko04217 Necroptosis 3/472 178/7206 0.00499787382758 ko04152 AMPK signaling pathway 3/472 161/7206 0.00939593434255 ko04140 Autophagy - animal 3/472 164/7206 0.00957867832459 ko04012 ErbB signaling pathway 1/472 109/7206 0.00985496814116 ko04727 GABAergic synapse 1/472 110/7206 0.00997947515483 ko05032 Morphine addiction 1/472 110/7206 0.00997947515483 ko05205 Proteoglycans in cancer 8/472 271/7206 0.0117422010658 ko05231 Choline metabolism in cancer 2/472 134/7206 0.0121694855102 ko04120 Ubiquitin mediated proteolysis 17/472 138/7206 0.0131310298194 ko03450 Non-homologous end-joining 4/472 15/7206 0.0138952843582 ko04925 Aldosterone synthesis and secretion 1/472 105/7206 0.0147683583668 ko01200 Carbon metabolism 2/472 128/7206 0.017267747238 ko04658 Th1 and Th2 cell differentiation 1/472 96/7206 0.0206208355338 ko05100 Bacterial invasion of epithelial cells 1/472 99/7206 0.0214464375097 ko05146 Amoebiasis 1/472 99/7206 0.0214464375097 ko03022 Basal transcription factors 7/472 44/7206 0.0229500335 ko05167 Kaposi's sarcoma-associated herpesvirus infection 5/472 191/7206 0.024742837372 ko04068 FoxO signaling pathway 4/472 167/7206 0.025324446303 ko05323 Rheumatoid arthritis 1/472 89/7206 0.029715395642 ko04210 Apoptosis 5/472 180/7206 0.0326360180992 ko04141 Protein processing in endoplasmic reticulum 5/472 184/7206 0.0330000870644 ko05131 Shigellosis 1/472 82/7206 0.0428517642216 ko04917 Prolactin signaling pathway 1/472 87/7206 0.0449605504469 ko04657 IL-17 signaling pathway 1/472 87/7206 0.0449605504469 ko01521 EGFR tyrosine kinase inhibitor resistance 2/472 106/7206 0.0469642706197 ko04922 Glucagon signaling pathway 3/472 128/7206 0.0474226226713 ko04630 Jak-STAT signaling pathway 3/472 132/7206 0.0481781926367