ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1311	423/7206	2.63956236712e-53
ko04724	Glutamatergic synapse	93/1311	152/7206	1.31081116429e-32
ko05033	Nicotine addiction	48/1311	56/7206	4.55493426189e-28
ko04713	Circadian entrainment	80/1311	136/7206	1.61435120707e-26
ko05032	Morphine addiction	70/1311	110/7206	2.89712566506e-26
ko04727	GABAergic synapse	68/1311	110/7206	1.82432549182e-24
ko04721	Synaptic vesicle cycle	52/1311	80/7206	2.02900460263e-20
ko04728	Dopaminergic synapse	87/1311	185/7206	8.18354779093e-20
ko04725	Cholinergic synapse	78/1311	160/7206	4.81577123336e-19
ko04020	Calcium signaling pathway	108/1311	265/7206	2.0090577656e-18
ko04024	cAMP signaling pathway	109/1311	279/7206	6.77242177663e-17
ko04723	Retrograde endocannabinoid signaling	79/1311	175/7206	8.62545914368e-17
ko04911	Insulin secretion	59/1311	117/7206	1.49791983759e-15
ko04742	Taste transduction	39/1311	61/7206	2.90496452378e-15
ko04726	Serotonergic synapse	63/1311	137/7206	4.30551815023e-14
ko04744	Phototransduction	27/1311	36/7206	1.43204972483e-13
ko04921	Oxytocin signaling pathway	82/1311	209/7206	4.31943620472e-13
ko03040	Spliceosome	1/1311	145/7206	9.31528620395e-12
ko04970	Salivary secretion	46/1311	95/7206	1.31202728203e-11
ko05031	Amphetamine addiction	44/1311	91/7206	3.90595201209e-11
ko04720	Long-term potentiation	46/1311	99/7206	7.88753019091e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1311	205/7206	2.7032008122e-10
ko04740	Olfactory transduction	39/1311	80/7206	3.73199753162e-10
ko04022	cGMP-PKG signaling pathway	74/1311	216/7206	9.38887902566e-09
ko04360	Axon guidance	77/1311	233/7206	3.2230845574e-08
ko03013	RNA transport	7/1311	166/7206	1.10903682095e-07
ko04925	Aldosterone synthesis and secretion	42/1311	105/7206	1.32632031552e-07
ko05168	Herpes simplex infection	9/1311	182/7206	1.51497305827e-07
ko05203	Viral carcinogenesis	20/1311	277/7206	1.73325418526e-07
ko04971	Gastric acid secretion	39/1311	98/7206	4.47363913492e-07
ko05322	Systemic lupus erythematosus	7/1311	151/7206	1.0232511445e-06
ko04540	Gap junction	46/1311	128/7206	1.36439222258e-06
ko05030	Cocaine addiction	31/1311	73/7206	1.558945636e-06
ko04924	Renin secretion	34/1311	86/7206	3.15374811176e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1311	74/7206	5.7785187577e-06
ko04060	Cytokine-cytokine receptor interaction	13/1311	191/7206	6.41839348821e-06
ko04966	Collecting duct acid secretion	15/1311	26/7206	7.53966841075e-06
ko04621	NOD-like receptor signaling pathway	9/1311	157/7206	8.00852111124e-06
ko04514	Cell adhesion molecules (CAMs)	45/1311	130/7206	8.57463379439e-06
ko04972	Pancreatic secretion	40/1311	111/7206	8.64333602348e-06
ko04010	MAPK signaling pathway	89/1311	321/7206	1.59274809006e-05
ko04141	Protein processing in endoplasmic reticulum	13/1311	184/7206	1.70590524171e-05
ko04730	Long-term depression	30/1311	78/7206	2.15128840681e-05
ko04120	Ubiquitin mediated proteolysis	8/1311	138/7206	2.95147279311e-05
ko04745	Phototransduction - fly	18/1311	38/7206	3.5368579393e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1311	79/7206	4.56982812312e-05
ko04976	Bile secretion	30/1311	80/7206	5.05416709367e-05
ko05164	Influenza A	12/1311	167/7206	6.27871027567e-05
ko04260	Cardiac muscle contraction	34/1311	98/7206	9.43272575208e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1311	122/7206	0.000117907182973
ko04110	Cell cycle	10/1311	145/7206	0.000121281819523
ko05169	Epstein-Barr virus infection	18/1311	206/7206	0.000155649327937
ko04070	Phosphatidylinositol signaling system	37/1311	112/7206	0.000164427674677
ko04146	Peroxisome	4/1311	89/7206	0.000246463228095
ko04014	Ras signaling pathway	75/1311	279/7206	0.000252694890717
ko04064	NF-kappa B signaling pathway	5/1311	96/7206	0.00027420164989
ko04612	Antigen processing and presentation	3/1311	77/7206	0.000289768029795
ko05414	Dilated cardiomyopathy	36/1311	112/7206	0.000300355323711
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1311	79/7206	0.000315279229204
ko00520	Amino sugar and nucleotide sugar metabolism	1/1311	55/7206	0.000325697550586
ko04072	Phospholipase D signaling pathway	56/1311	197/7206	0.000341680015341
ko05140	Leishmaniasis	3/1311	75/7206	0.000426960815825
ko05110	Vibrio cholerae infection	23/1311	63/7206	0.000471179187603
ko04964	Proximal tubule bicarbonate reclamation	13/1311	29/7206	0.000842627930394
ko04923	Regulation of lipolysis in adipocytes	26/1311	77/7206	0.000921860526347
ko04610	Complement and coagulation cascades	4/1311	79/7206	0.00105653689892
ko05162	Measles	9/1311	120/7206	0.0011665297261
ko03420	Nucleotide excision repair	1/1311	46/7206	0.00174749455467
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1311	59/7206	0.00177567667956
ko05131	Shigellosis	5/1311	82/7206	0.00228982618559
ko04710	Circadian rhythm	16/1311	43/7206	0.00264922234986
ko03022	Basal transcription factors	1/1311	44/7206	0.00266249273692
ko05161	Hepatitis B	17/1311	173/7206	0.00266954419025
ko00071	Fatty acid degradation	1/1311	45/7206	0.00279067849711
ko05205	Proteoglycans in cancer	31/1311	271/7206	0.0028639539378
ko04270	Vascular smooth muscle contraction	43/1311	154/7206	0.00289402927498
ko04371	Apelin signaling pathway	48/1311	177/7206	0.00293726207127
ko00310	Lysine degradation	4/1311	73/7206	0.00322491569238
ko00240	Pyrimidine metabolism	9/1311	110/7206	0.00400984811005
ko04622	RIG-I-like receptor signaling pathway	3/1311	62/7206	0.00422238849018
ko04657	IL-17 signaling pathway	6/1311	87/7206	0.00464087515065
ko05133	Pertussis	6/1311	87/7206	0.00464087515065
ko05145	Toxoplasmosis	11/1311	126/7206	0.00479679737696
ko03018	RNA degradation	6/1311	84/7206	0.00632346065229
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1311	14/7206	0.0067578354267
ko05219	Bladder cancer	2/1311	48/7206	0.00767212054771
ko04915	Estrogen signaling pathway	36/1311	131/7206	0.00818608370605
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1311	100/7206	0.00839533496829
ko05321	Inflammatory bowel disease (IBD)	3/1311	56/7206	0.00851052400116
ko04626	Plant-pathogen interaction	8/1311	18/7206	0.00912200703259
ko00630	Glyoxylate and dicarboxylate metabolism	1/1311	38/7206	0.00954030864427
ko04922	Glucagon signaling pathway	35/1311	128/7206	0.0104641148686
ko04658	Th1 and Th2 cell differentiation	8/1311	96/7206	0.0106865292101
ko04916	Melanogenesis	38/1311	142/7206	0.0110578717617
ko05144	Malaria	2/1311	45/7206	0.0112125075412
ko04630	Jak-STAT signaling pathway	13/1311	132/7206	0.0117038384567
ko00280	Valine, leucine and isoleucine degradation	3/1311	54/7206	0.0122483239397
ko04960	Aldosterone-regulated sodium reabsorption	14/1311	41/7206	0.0133509255199
ko00860	Porphyrin and chlorophyll metabolism	1/1311	34/7206	0.0138644411447
ko04973	Carbohydrate digestion and absorption	14/1311	42/7206	0.0156494414715
ko05132	Salmonella infection	9/1311	98/7206	0.0173062033324
ko04210	Apoptosis	21/1311	180/7206	0.0189171803214
ko04930	Type II diabetes mellitus	17/1311	54/7206	0.0194464264051
ko04115	p53 signaling pathway	6/1311	74/7206	0.0222433263751
ko04217	Necroptosis	21/1311	178/7206	0.0235207230099
ko05166	HTLV-I infection	39/1311	292/7206	0.0298572371463
ko04214	Apoptosis - fly	6/1311	72/7206	0.0303406134782
ko05340	Primary immunodeficiency	1/1311	30/7206	0.0312523575545
ko03410	Base excision repair	2/1311	38/7206	0.0346872154057
ko04620	Toll-like receptor signaling pathway	10/1311	100/7206	0.0356780855622
ko04015	Rap1 signaling pathway	64/1311	278/7206	0.0389426455962
ko05231	Choline metabolism in cancer	34/1311	134/7206	0.0409432174796
ko04113	Meiosis - yeast	6/1311	70/7206	0.0412807159549
ko04912	GnRH signaling pathway	31/1311	122/7206	0.0437001309131
ko00330	Arginine and proline metabolism	5/1311	61/7206	0.0443055525287
ko05215	Prostate cancer	12/1311	111/7206	0.0463647651511
ko00590	Arachidonic acid metabolism	4/1311	52/7206	0.0473878228899
ko04918	Thyroid hormone synthesis	23/1311	86/7206	0.0479211225865
ko05206	MicroRNAs in cancer	22/1311	177/7206	0.047954750442