ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 13/132 30/7206 1.32120830941e-15 ko04060 Cytokine-cytokine receptor interaction 23/132 191/7206 3.55499916814e-13 ko04650 Natural killer cell mediated cytotoxicity 16/132 97/7206 1.45041579505e-11 ko05330 Allograft rejection 9/132 24/7206 1.8302224262e-10 ko04612 Antigen processing and presentation 13/132 77/7206 9.778966469e-10 ko05152 Tuberculosis 18/132 187/7206 6.52274185383e-09 ko05140 Leishmaniasis 12/132 75/7206 8.44999108366e-09 ko05332 Graft-versus-host disease 7/132 18/7206 1.58792944381e-08 ko04380 Osteoclast differentiation 15/132 134/7206 1.69817225049e-08 ko04660 T cell receptor signaling pathway 14/132 124/7206 4.70676383353e-08 ko05145 Toxoplasmosis 14/132 126/7206 5.78069227109e-08 ko05144 Malaria 9/132 45/7206 8.96059258573e-08 ko04145 Phagosome 15/132 162/7206 2.19123040952e-07 ko05321 Inflammatory bowel disease (IBD) 9/132 56/7206 6.46152511931e-07 ko05320 Autoimmune thyroid disease 7/132 29/7206 6.58310674991e-07 ko04940 Type I diabetes mellitus 7/132 32/7206 1.3561206265e-06 ko04659 Th17 cell differentiation 11/132 106/7206 3.24940426618e-06 ko04064 NF-kappa B signaling pathway 10/132 96/7206 8.9594295468e-06 ko05310 Asthma 5/132 17/7206 9.91382384792e-06 ko05168 Herpes simplex infection 13/132 182/7206 2.58890520178e-05 ko05150 Staphylococcus aureus infection 6/132 36/7206 4.1817058224e-05 ko04672 Intestinal immune network for IgA production 6/132 37/7206 4.91667840931e-05 ko05162 Measles 10/132 120/7206 6.3553106183e-05 ko04062 Chemokine signaling pathway 13/132 201/7206 7.30592768432e-05 ko04666 Fc gamma R-mediated phagocytosis 10/132 122/7206 7.31621301611e-05 ko04620 Toll-like receptor signaling pathway 9/132 100/7206 8.22138681892e-05 ko04640 Hematopoietic cell lineage 7/132 64/7206 0.000153774656183 ko05323 Rheumatoid arthritis 8/132 89/7206 0.000208356175578 ko05164 Influenza A 11/132 167/7206 0.00022847797313 ko04658 Th1 and Th2 cell differentiation 8/132 96/7206 0.000351449436779 ko03050 Proteasome 6/132 54/7206 0.000423385308898 ko04670 Leukocyte transendothelial migration 10/132 151/7206 0.00042444288267 ko05416 Viral myocarditis 6/132 55/7206 0.000468176103615 ko04664 Fc epsilon RI signaling pathway 7/132 77/7206 0.000488761592334 ko04514 Cell adhesion molecules (CAMs) 9/132 130/7206 0.000599403267734 ko04630 Jak-STAT signaling pathway 9/132 132/7206 0.000669789381172 ko05133 Pertussis 7/132 87/7206 0.0010208285975 ko04662 B cell receptor signaling pathway 7/132 88/7206 0.0010924079066 ko05161 Hepatitis B 10/132 173/7206 0.00122464484519 ko05146 Amoebiasis 7/132 99/7206 0.00216969006581 ko05142 Chagas disease (American trypanosomiasis) 8/132 130/7206 0.00256202282887 ko04622 RIG-I-like receptor signaling pathway 5/132 62/7206 0.00536593718059 ko04621 NOD-like receptor signaling pathway 8/132 157/7206 0.00799466156546 ko05167 Kaposi's sarcoma-associated herpesvirus infection 9/132 191/7206 0.00822724469364 ko05166 HTLV-I infection 12/132 292/7206 0.0111157462242 ko04610 Complement and coagulation cascades 5/132 79/7206 0.0146162830719 ko04210 Apoptosis 8/132 180/7206 0.0172567777305 ko05143 African trypanosomiasis 3/132 32/7206 0.0202318765274 ko05322 Systemic lupus erythematosus 7/132 151/7206 0.0206118370539 ko04080 Neuroactive ligand-receptor interaction 2/132 423/7206 0.0241878530375 ko04611 Platelet activation 7/132 163/7206 0.0297621135142 ko05132 Salmonella infection 5/132 98/7206 0.0335369318182 ko04144 Endocytosis 12/132 342/7206 0.03433946757 ko05020 Prion diseases 3/132 40/7206 0.0362770321799 ko04217 Necroptosis 7/132 178/7206 0.0446305137743 ko05134 Legionellosis 4/132 74/7206 0.0463098156733