ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1222	423/7206	1.78728741659e-60
ko04724	Glutamatergic synapse	98/1222	152/7206	6.37687438464e-40
ko05032	Morphine addiction	76/1222	110/7206	2.95442642972e-34
ko05033	Nicotine addiction	50/1222	56/7206	1.43477521744e-32
ko04713	Circadian entrainment	83/1222	136/7206	2.35551279513e-31
ko04727	GABAergic synapse	71/1222	110/7206	3.60169149294e-29
ko04728	Dopaminergic synapse	89/1222	185/7206	2.77091515626e-23
ko04725	Cholinergic synapse	81/1222	160/7206	4.18415175849e-23
ko04723	Retrograde endocannabinoid signaling	84/1222	175/7206	6.04543645569e-22
ko04020	Calcium signaling pathway	109/1222	265/7206	2.10433523633e-21
ko04721	Synaptic vesicle cycle	51/1222	80/7206	6.72383210473e-21
ko04024	cAMP signaling pathway	110/1222	279/7206	8.38048452328e-20
ko04911	Insulin secretion	61/1222	117/7206	1.72035372689e-18
ko04726	Serotonergic synapse	67/1222	137/7206	2.91151373929e-18
ko04921	Oxytocin signaling pathway	84/1222	209/7206	8.52194703107e-16
ko04744	Phototransduction	28/1222	36/7206	1.52349234417e-15
ko04742	Taste transduction	37/1222	61/7206	1.71113588381e-14
ko04720	Long-term potentiation	49/1222	99/7206	6.06361884498e-14
ko05031	Amphetamine addiction	46/1222	91/7206	1.33632977164e-13
ko04970	Salivary secretion	46/1222	95/7206	9.95038726982e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1222	205/7206	2.16826208028e-12
ko03040	Spliceosome	1/1222	145/7206	7.14905702288e-11
ko04925	Aldosterone synthesis and secretion	44/1222	105/7206	1.16139670894e-09
ko04971	Gastric acid secretion	42/1222	98/7206	1.21239617682e-09
ko03010	Ribosome	1/1222	129/7206	1.52947290536e-09
ko04740	Olfactory transduction	35/1222	80/7206	1.53980469266e-08
ko05322	Systemic lupus erythematosus	4/1222	151/7206	3.5941630857e-08
ko05030	Cocaine addiction	32/1222	73/7206	6.0287149161e-08
ko04022	cGMP-PKG signaling pathway	68/1222	216/7206	9.66869784424e-08
ko05203	Viral carcinogenesis	18/1222	277/7206	2.94162648221e-07
ko04972	Pancreatic secretion	41/1222	111/7206	3.17234689425e-07
ko03013	RNA transport	7/1222	166/7206	5.73725251165e-07
ko04070	Phosphatidylinositol signaling system	41/1222	112/7206	6.14915510941e-07
ko05168	Herpes simplex infection	9/1222	182/7206	1.09136998921e-06
ko04360	Axon guidance	69/1222	233/7206	1.19260243188e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1222	74/7206	1.20907732648e-06
ko04730	Long-term depression	31/1222	78/7206	1.80903594779e-06
ko04745	Phototransduction - fly	19/1222	38/7206	2.70518382924e-06
ko04010	MAPK signaling pathway	87/1222	321/7206	2.91292012197e-06
ko04141	Protein processing in endoplasmic reticulum	10/1222	184/7206	3.41166639148e-06
ko04540	Gap junction	43/1222	128/7206	3.84372465287e-06
ko04060	Cytokine-cytokine receptor interaction	11/1222	191/7206	5.11345030499e-06
ko04072	Phospholipase D signaling pathway	58/1222	197/7206	1.13433458488e-05
ko04514	Cell adhesion molecules (CAMs)	42/1222	130/7206	1.51939433553e-05
ko04110	Cell cycle	7/1222	145/7206	1.54472884992e-05
ko04966	Collecting duct acid secretion	14/1222	26/7206	1.92579674058e-05
ko04612	Antigen processing and presentation	1/1222	77/7206	1.981036944e-05
ko05164	Influenza A	10/1222	167/7206	3.7073080484e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1222	122/7206	4.28679205258e-05
ko05110	Vibrio cholerae infection	24/1222	63/7206	5.52846207601e-05
ko04924	Renin secretion	30/1222	86/7206	5.92157131172e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1222	59/7206	6.0944939769e-05
ko05169	Epstein-Barr virus infection	15/1222	206/7206	6.43168064714e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1222	79/7206	0.000110637009442
ko04621	NOD-like receptor signaling pathway	10/1222	157/7206	0.000138073299065
ko05414	Dilated cardiomyopathy	35/1222	112/7206	0.000181635700084
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1222	79/7206	0.000203713815076
ko04014	Ras signaling pathway	71/1222	279/7206	0.000234961629082
ko05162	Measles	7/1222	120/7206	0.000495491891074
ko04120	Ubiquitin mediated proteolysis	9/1222	138/7206	0.000503921375354
ko04915	Estrogen signaling pathway	38/1222	131/7206	0.000561403146411
ko04976	Bile secretion	26/1222	80/7206	0.000756433391914
ko00520	Amino sugar and nucleotide sugar metabolism	1/1222	55/7206	0.000843596546093
ko04630	Jak-STAT signaling pathway	9/1222	132/7206	0.000928357321218
ko04260	Cardiac muscle contraction	30/1222	98/7206	0.000940866950311
ko04912	GnRH signaling pathway	35/1222	122/7206	0.00135991702137
ko04923	Regulation of lipolysis in adipocytes	24/1222	77/7206	0.001938618394
ko04918	Thyroid hormone synthesis	26/1222	86/7206	0.00210558420079
ko04371	Apelin signaling pathway	46/1222	177/7206	0.00218847494382
ko04610	Complement and coagulation cascades	4/1222	79/7206	0.00232521789263
ko04922	Glucagon signaling pathway	35/1222	128/7206	0.00277870177987
ko04064	NF-kappa B signaling pathway	6/1222	96/7206	0.00358660516224
ko04710	Circadian rhythm	15/1222	43/7206	0.00372668022675
ko03022	Basal transcription factors	1/1222	44/7206	0.00428199007828
ko05144	Malaria	1/1222	45/7206	0.00433673848619
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1222	14/7206	0.00450377005832
ko00240	Pyrimidine metabolism	8/1222	110/7206	0.00451875236161
ko03420	Nucleotide excision repair	1/1222	46/7206	0.00457352694884
ko04115	p53 signaling pathway	4/1222	74/7206	0.00469654109975
ko05161	Hepatitis B	16/1222	173/7206	0.00534250937828
ko04626	Plant-pathogen interaction	8/1222	18/7206	0.00589061547408
ko04960	Aldosterone-regulated sodium reabsorption	14/1222	41/7206	0.00618875133291
ko04330	Notch signaling pathway	3/1222	62/7206	0.00628540046017
ko04622	RIG-I-like receptor signaling pathway	3/1222	62/7206	0.00628540046017
ko05231	Choline metabolism in cancer	35/1222	134/7206	0.00710109040756
ko05205	Proteoglycans in cancer	30/1222	271/7206	0.00805882364141
ko00590	Arachidonic acid metabolism	2/1222	52/7206	0.00822968020036
ko05166	HTLV-I infection	33/1222	292/7206	0.00839219122708
ko04270	Vascular smooth muscle contraction	39/1222	154/7206	0.00872672248755
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1222	182/7206	0.00898030889087
ko03320	PPAR signaling pathway	4/1222	69/7206	0.00936513315183
ko00562	Inositol phosphate metabolism	25/1222	89/7206	0.00963471113475
ko04062	Chemokine signaling pathway	48/1222	201/7206	0.00999381881318
ko05202	Transcriptional misregulation in cancer	19/1222	188/7206	0.0101424204302
ko05215	Prostate cancer	9/1222	111/7206	0.0103047671958
ko04973	Carbohydrate digestion and absorption	14/1222	42/7206	0.0110913934062
ko04217	Necroptosis	18/1222	178/7206	0.0113680582683
ko04015	Rap1 signaling pathway	63/1222	278/7206	0.0115043884986
ko05016	Huntington's disease	23/1222	215/7206	0.0124139508168
ko03018	RNA degradation	6/1222	84/7206	0.0125000489158
ko05140	Leishmaniasis	5/1222	75/7206	0.0129782866851
ko03410	Base excision repair	1/1222	38/7206	0.0148890678813
ko04916	Melanogenesis	35/1222	142/7206	0.017396560715
ko04930	Type II diabetes mellitus	16/1222	54/7206	0.0176381168509
ko00310	Lysine degradation	5/1222	73/7206	0.0179302154576
ko00480	Glutathione metabolism	3/1222	55/7206	0.0182783125621
ko05321	Inflammatory bowel disease (IBD)	3/1222	56/7206	0.0185607619762
ko04658	Th1 and Th2 cell differentiation	8/1222	96/7206	0.0198026160522
ko04657	IL-17 signaling pathway	7/1222	87/7206	0.0215412408772
ko05133	Pertussis	7/1222	87/7206	0.0215412408772
ko04964	Proximal tubule bicarbonate reclamation	10/1222	29/7206	0.0215970443234
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1222	100/7206	0.0216161659201
ko00860	Porphyrin and chlorophyll metabolism	1/1222	34/7206	0.0217749790191
ko05222	Small cell lung cancer	7/1222	89/7206	0.0218312648733
ko04114	Oocyte meiosis	34/1222	139/7206	0.0220068607165
ko05145	Toxoplasmosis	12/1222	126/7206	0.0226162365029
ko00230	Purine metabolism	45/1222	194/7206	0.0251518953862
ko00071	Fatty acid degradation	2/1222	45/7206	0.0257938707878
ko04210	Apoptosis	20/1222	180/7206	0.0343308922976
ko04142	Lysosome	16/1222	151/7206	0.0367233247526
ko05131	Shigellosis	7/1222	82/7206	0.0383464727082
ko04510	Focal adhesion	29/1222	240/7206	0.0437642389334
ko04146	Peroxisome	8/1222	89/7206	0.0457739980691