ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1294	423/7206	6.55249589078e-53
ko04724	Glutamatergic synapse	95/1294	152/7206	7.03910762568e-35
ko05033	Nicotine addiction	49/1294	56/7206	8.43556762303e-30
ko04713	Circadian entrainment	82/1294	136/7206	1.27024067555e-28
ko04727	GABAergic synapse	71/1294	110/7206	1.48243953014e-27
ko05032	Morphine addiction	71/1294	110/7206	1.48243953014e-27
ko04728	Dopaminergic synapse	88/1294	185/7206	7.67678738959e-21
ko04725	Cholinergic synapse	79/1294	160/7206	4.5767215806e-20
ko04020	Calcium signaling pathway	110/1294	265/7206	6.93130552883e-20
ko04721	Synaptic vesicle cycle	50/1294	80/7206	7.60494093892e-19
ko04024	cAMP signaling pathway	110/1294	279/7206	9.07180738442e-18
ko04723	Retrograde endocannabinoid signaling	80/1294	175/7206	9.73487802282e-18
ko04726	Serotonergic synapse	65/1294	137/7206	1.29397117059e-15
ko04742	Taste transduction	39/1294	61/7206	1.84252626939e-15
ko04921	Oxytocin signaling pathway	85/1294	209/7206	5.81431750144e-15
ko04911	Insulin secretion	57/1294	117/7206	1.77048493339e-14
ko04744	Phototransduction	27/1294	36/7206	1.02827856146e-13
ko04970	Salivary secretion	48/1294	95/7206	3.76786029022e-13
ko04740	Olfactory transduction	43/1294	80/7206	4.04596932131e-13
ko05031	Amphetamine addiction	46/1294	91/7206	1.14962463982e-12
ko04720	Long-term potentiation	48/1294	99/7206	2.68368989658e-12
ko04022	cGMP-PKG signaling pathway	78/1294	216/7206	1.09036228768e-10
ko04261	Adrenergic signaling in cardiomyocytes	75/1294	205/7206	1.22053667421e-10
ko03040	Spliceosome	2/1294	145/7206	2.22663268382e-10
ko03010	Ribosome	1/1294	129/7206	3.38704653681e-10
ko04925	Aldosterone synthesis and secretion	44/1294	105/7206	8.16554403441e-09
ko05203	Viral carcinogenesis	17/1294	277/7206	8.77105152924e-09
ko05168	Herpes simplex infection	8/1294	182/7206	4.38066301446e-08
ko05322	Systemic lupus erythematosus	5/1294	151/7206	4.44557503967e-08
ko03013	RNA transport	7/1294	166/7206	1.70146669253e-07
ko05030	Cocaine addiction	32/1294	73/7206	2.39751744815e-07
ko04060	Cytokine-cytokine receptor interaction	10/1294	191/7206	2.57186862183e-07
ko04971	Gastric acid secretion	39/1294	98/7206	3.48667946803e-07
ko04540	Gap junction	46/1294	128/7206	1.0498040577e-06
ko04110	Cell cycle	7/1294	145/7206	3.19665755291e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1294	74/7206	4.54178098608e-06
ko04924	Renin secretion	33/1294	86/7206	6.51278327648e-06
ko04730	Long-term depression	31/1294	78/7206	8.00345343205e-06
ko04070	Phosphatidylinositol signaling system	40/1294	112/7206	8.55667782141e-06
ko04371	Apelin signaling pathway	56/1294	177/7206	9.51821286683e-06
ko04360	Axon guidance	69/1294	233/7206	1.15797707198e-05
ko04750	Inflammatory mediator regulation of TRP channels	42/1294	122/7206	1.215426236e-05
ko05164	Influenza A	11/1294	167/7206	2.41447933529e-05
ko04745	Phototransduction - fly	18/1294	38/7206	2.94452344436e-05
ko04621	NOD-like receptor signaling pathway	10/1294	157/7206	3.30763566521e-05
ko04966	Collecting duct acid secretion	14/1294	26/7206	3.77673342184e-05
ko04120	Ubiquitin mediated proteolysis	8/1294	138/7206	4.30736163467e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1294	79/7206	4.44054072934e-05
ko04514	Cell adhesion molecules (CAMs)	42/1294	130/7206	6.82977163628e-05
ko04141	Protein processing in endoplasmic reticulum	14/1294	184/7206	8.37682253221e-05
ko04972	Pancreatic secretion	37/1294	111/7206	8.49516925422e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1294	79/7206	0.000175052897192
ko04010	MAPK signaling pathway	84/1294	321/7206	0.00018521150024
ko05169	Epstein-Barr virus infection	18/1294	206/7206	0.000210873574245
ko04072	Phospholipase D signaling pathway	56/1294	197/7206	0.000224438319331
ko05414	Dilated cardiomyopathy	36/1294	112/7206	0.000259129542026
ko04014	Ras signaling pathway	74/1294	279/7206	0.000316770797929
ko04626	Plant-pathogen interaction	10/1294	18/7206	0.000362928700159
ko05110	Vibrio cholerae infection	23/1294	63/7206	0.000403933441335
ko04064	NF-kappa B signaling pathway	5/1294	96/7206	0.000405046149879
ko04260	Cardiac muscle contraction	32/1294	98/7206	0.000455105173583
ko04976	Bile secretion	27/1294	80/7206	0.000613478209537
ko05140	Leishmaniasis	3/1294	75/7206	0.000673133200294
ko04330	Notch signaling pathway	2/1294	62/7206	0.000740151005782
ko04923	Regulation of lipolysis in adipocytes	26/1294	77/7206	0.000817754297813
ko04214	Apoptosis - fly	3/1294	72/7206	0.000950180079322
ko04922	Glucagon signaling pathway	38/1294	128/7206	0.00102693044386
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1294	59/7206	0.00103112945953
ko05166	HTLV-I infection	32/1294	292/7206	0.00103347885599
ko04610	Complement and coagulation cascades	4/1294	79/7206	0.00107027572588
ko05162	Measles	9/1294	120/7206	0.00163468448692
ko04657	IL-17 signaling pathway	5/1294	87/7206	0.00169303663587
ko04915	Estrogen signaling pathway	38/1294	131/7206	0.00175194700351
ko05161	Hepatitis B	16/1294	173/7206	0.00175674204334
ko03420	Nucleotide excision repair	1/1294	46/7206	0.00177928263025
ko04710	Circadian rhythm	16/1294	43/7206	0.00234917098417
ko00520	Amino sugar and nucleotide sugar metabolism	2/1294	55/7206	0.00241563902752
ko00480	Glutathione metabolism	2/1294	55/7206	0.00241563902752
ko05321	Inflammatory bowel disease (IBD)	2/1294	56/7206	0.00244527005912
ko03022	Basal transcription factors	1/1294	44/7206	0.00268585996483
ko05144	Malaria	1/1294	45/7206	0.00273694988397
ko04146	Peroxisome	6/1294	89/7206	0.00329927051604
ko05205	Proteoglycans in cancer	31/1294	271/7206	0.00357924830368
ko04622	RIG-I-like receptor signaling pathway	3/1294	62/7206	0.00416586240005
ko00590	Arachidonic acid metabolism	2/1294	52/7206	0.00548052094715
ko04930	Type II diabetes mellitus	18/1294	54/7206	0.00652057127408
ko04612	Antigen processing and presentation	5/1294	77/7206	0.00653454211496
ko05219	Bladder cancer	2/1294	48/7206	0.00772475187253
ko00562	Inositol phosphate metabolism	26/1294	89/7206	0.00798276617957
ko05131	Shigellosis	6/1294	82/7206	0.00874791594001
ko05145	Toxoplasmosis	12/1294	126/7206	0.00993435602301
ko04658	Th1 and Th2 cell differentiation	8/1294	96/7206	0.0106338749307
ko04668	TNF signaling pathway	11/1294	120/7206	0.011162861942
ko04630	Jak-STAT signaling pathway	13/1294	132/7206	0.0116714816409
ko04964	Proximal tubule bicarbonate reclamation	11/1294	29/7206	0.0119667143414
ko04912	GnRH signaling pathway	33/1294	122/7206	0.0119938972162
ko00240	Pyrimidine metabolism	10/1294	110/7206	0.012018392017
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1294	100/7206	0.0121553691935
ko04960	Aldosterone-regulated sodium reabsorption	14/1294	41/7206	0.0124795164624
ko04210	Apoptosis	20/1294	180/7206	0.0137428825343
ko04973	Carbohydrate digestion and absorption	14/1294	42/7206	0.0144702509501
ko05133	Pertussis	7/1294	87/7206	0.015850737142
ko04270	Vascular smooth muscle contraction	39/1294	154/7206	0.0193977419412
ko03018	RNA degradation	7/1294	84/7206	0.0210601468529
ko04213	Longevity regulating pathway - multiple species	24/1294	86/7206	0.0226464090146
ko01524	Platinum drug resistance	6/1294	76/7206	0.0228723574853
ko05200	Pathways in cancer	70/1294	492/7206	0.0243943481527
ko05215	Prostate cancer	11/1294	111/7206	0.0244704563664
ko05217	Basal cell carcinoma	5/1294	68/7206	0.0246109544268
ko05214	Glioma	22/1294	79/7206	0.0266257519018
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1294	14/7206	0.026863168275
ko04350	TGF-beta signaling pathway	10/1294	103/7206	0.027341389035
ko04217	Necroptosis	21/1294	178/7206	0.0293845960483
ko05231	Choline metabolism in cancer	34/1294	134/7206	0.0302601034576
ko04142	Lysosome	17/1294	151/7206	0.0315250675926
ko04640	Hematopoietic cell lineage	5/1294	64/7206	0.0326228161499
ko04620	Toll-like receptor signaling pathway	10/1294	100/7206	0.0355575288633
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1294	40/7206	0.0359277084494
ko05016	Huntington's disease	27/1294	215/7206	0.0376592088572
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1294	182/7206	0.0394234912903
ko05230	Central carbon metabolism in cancer	22/1294	81/7206	0.040145932955
ko04113	Meiosis - yeast	6/1294	70/7206	0.0409653789778
ko05212	Pancreatic cancer	8/1294	83/7206	0.0445116838742
ko05418	Fluid shear stress and atherosclerosis	21/1294	173/7206	0.0446592060247
ko00010	Glycolysis / Gluconeogenesis	20/1294	74/7206	0.0474992876902