ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	183/1128	423/7206	7.08959477915e-45
ko04724	Glutamatergic synapse	84/1128	152/7206	5.550203966e-30
ko05033	Nicotine addiction	46/1128	56/7206	2.93140805071e-28
ko05032	Morphine addiction	65/1128	110/7206	1.15000787605e-25
ko04713	Circadian entrainment	72/1128	136/7206	2.70569273115e-24
ko04721	Synaptic vesicle cycle	51/1128	80/7206	1.61313122088e-22
ko04727	GABAergic synapse	61/1128	110/7206	3.85883911772e-22
ko04725	Cholinergic synapse	74/1128	160/7206	2.27301006901e-20
ko04728	Dopaminergic synapse	80/1128	185/7206	1.09596959245e-19
ko04024	cAMP signaling pathway	101/1128	279/7206	8.98397013591e-18
ko04723	Retrograde endocannabinoid signaling	74/1128	175/7206	1.27932078388e-17
ko04742	Taste transduction	38/1128	61/7206	1.36928226691e-16
ko04020	Calcium signaling pathway	94/1128	265/7206	7.66456906717e-16
ko04921	Oxytocin signaling pathway	79/1128	209/7206	2.45397290486e-15
ko04911	Insulin secretion	53/1128	117/7206	1.89355282451e-14
ko04726	Serotonergic synapse	57/1128	137/7206	1.78092873439e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1128	205/7206	1.30866401037e-11
ko04970	Salivary secretion	41/1128	95/7206	1.18668478675e-10
ko04720	Long-term potentiation	42/1128	99/7206	1.36406532041e-10
ko05031	Amphetamine addiction	39/1128	91/7206	4.35470029796e-10
ko03040	Spliceosome	1/1128	145/7206	8.53217044163e-10
ko04360	Axon guidance	71/1128	233/7206	6.96174028337e-09
ko04744	Phototransduction	20/1128	36/7206	3.91735942711e-08
ko04925	Aldosterone synthesis and secretion	39/1128	105/7206	6.97162908264e-08
ko04971	Gastric acid secretion	37/1128	98/7206	1.23445973104e-07
ko04740	Olfactory transduction	31/1128	80/7206	4.27443508748e-07
ko05203	Viral carcinogenesis	16/1128	277/7206	4.70045995937e-07
ko05168	Herpes simplex infection	7/1128	182/7206	4.72082165799e-07
ko05164	Influenza A	6/1128	167/7206	8.08788347863e-07
ko04022	cGMP-PKG signaling pathway	62/1128	216/7206	8.30414030771e-07
ko03013	RNA transport	6/1128	166/7206	1.20751613147e-06
ko05030	Cocaine addiction	28/1128	73/7206	1.96234766674e-06
ko04060	Cytokine-cytokine receptor interaction	9/1128	191/7206	2.58492041721e-06
ko04972	Pancreatic secretion	37/1128	111/7206	3.89754049033e-06
ko04010	MAPK signaling pathway	81/1128	321/7206	6.1844039097e-06
ko04966	Collecting duct acid secretion	14/1128	26/7206	7.40101924952e-06
ko04924	Renin secretion	30/1128	86/7206	8.6689034642e-06
ko04514	Cell adhesion molecules (CAMs)	40/1128	130/7206	1.31703886736e-05
ko04540	Gap junction	39/1128	128/7206	2.07713556593e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1128	74/7206	3.15365494824e-05
ko04610	Complement and coagulation cascades	1/1128	79/7206	3.27864132365e-05
ko05322	Systemic lupus erythematosus	7/1128	151/7206	3.51032854125e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1128	79/7206	5.64021033814e-05
ko04745	Phototransduction - fly	16/1128	38/7206	8.47146364101e-05
ko05414	Dilated cardiomyopathy	34/1128	112/7206	0.000103775368566
ko04730	Long-term depression	26/1128	78/7206	0.000104205572305
ko05169	Epstein-Barr virus infection	14/1128	206/7206	0.000134975520175
ko04976	Bile secretion	26/1128	80/7206	0.000145837406941
ko04371	Apelin signaling pathway	47/1128	177/7206	0.000146257337513
ko04141	Protein processing in endoplasmic reticulum	12/1128	184/7206	0.000197328510465
ko04260	Cardiac muscle contraction	30/1128	98/7206	0.000197632032253
ko04120	Ubiquitin mediated proteolysis	7/1128	138/7206	0.000198459113015
ko04014	Ras signaling pathway	67/1128	279/7206	0.000200342227251
ko04621	NOD-like receptor signaling pathway	9/1128	157/7206	0.00020772207777
ko03008	Ribosome biogenesis in eukaryotes	2/1128	79/7206	0.000267086126922
ko04750	Inflammatory mediator regulation of TRP channels	34/1128	122/7206	0.000572405231538
ko05140	Leishmaniasis	2/1128	75/7206	0.000598944494953
ko04064	NF-kappa B signaling pathway	4/1128	96/7206	0.000604058975255
ko05110	Vibrio cholerae infection	21/1128	63/7206	0.000645999716864
ko04626	Plant-pathogen interaction	9/1128	18/7206	0.000694259070398
ko04964	Proximal tubule bicarbonate reclamation	12/1128	29/7206	0.000790044067784
ko04915	Estrogen signaling pathway	35/1128	131/7206	0.000955720907277
ko05205	Proteoglycans in cancer	24/1128	271/7206	0.00113909024687
ko04072	Phospholipase D signaling pathway	48/1128	197/7206	0.00134679305377
ko05162	Measles	7/1128	120/7206	0.00140858718215
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1128	59/7206	0.00164052266903
ko04146	Peroxisome	4/1128	89/7206	0.00177196855787
ko05161	Hepatitis B	13/1128	173/7206	0.0019662074246
ko04612	Antigen processing and presentation	3/1128	77/7206	0.00229895072315
ko04070	Phosphatidylinositol signaling system	30/1128	112/7206	0.00229994525357
ko04110	Cell cycle	10/1128	145/7206	0.00243729102329
ko00330	Arginine and proline metabolism	2/1128	61/7206	0.00403510976712
ko00240	Pyrimidine metabolism	7/1128	110/7206	0.00504826686599
ko05144	Malaria	1/1128	45/7206	0.0068409888953
ko00071	Fatty acid degradation	1/1128	45/7206	0.0068409888953
ko03420	Nucleotide excision repair	1/1128	46/7206	0.00692234190414
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1128	100/7206	0.00774005973358
ko04930	Type II diabetes mellitus	16/1128	54/7206	0.00792156428853
ko05166	HTLV-I infection	30/1128	292/7206	0.00839700553175
ko00480	Glutathione metabolism	2/1128	55/7206	0.00855502657119
ko05321	Inflammatory bowel disease (IBD)	2/1128	56/7206	0.00864751051653
ko01524	Platinum drug resistance	4/1128	76/7206	0.0100953931601
ko04923	Regulation of lipolysis in adipocytes	21/1128	77/7206	0.0104676281786
ko03022	Basal transcription factors	1/1128	44/7206	0.0105977283282
ko00280	Valine, leucine and isoleucine degradation	2/1128	54/7206	0.0128349537463
ko04270	Vascular smooth muscle contraction	36/1128	154/7206	0.0130462147409
ko05145	Toxoplasmosis	10/1128	126/7206	0.0131348858435
ko04622	RIG-I-like receptor signaling pathway	3/1128	62/7206	0.0135126911785
ko05131	Shigellosis	5/1128	82/7206	0.0136943974216
ko04214	Apoptosis - fly	4/1128	72/7206	0.0138365915124
ko04640	Hematopoietic cell lineage	3/1128	64/7206	0.0140096934401
ko00310	Lysine degradation	4/1128	73/7206	0.0140211012194
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1128	14/7206	0.0140723910424
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1128	40/7206	0.0152629752864
ko00140	Steroid hormone biosynthesis	1/1128	41/7206	0.0155750382319
ko04912	GnRH signaling pathway	29/1128	122/7206	0.0166642119011
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1128	182/7206	0.0170163592496
ko00380	Tryptophan metabolism	2/1128	50/7206	0.0180310450185
ko04916	Melanogenesis	33/1128	142/7206	0.0188604988187
ko04630	Jak-STAT signaling pathway	11/1128	132/7206	0.020745192158
ko04668	TNF signaling pathway	10/1128	120/7206	0.0225398442543
ko04658	Th1 and Th2 cell differentiation	7/1128	96/7206	0.0226543030623
ko00982	Drug metabolism - cytochrome P450	1/1128	37/7206	0.022732911728
ko03410	Base excision repair	1/1128	38/7206	0.0229520714916
ko04657	IL-17 signaling pathway	6/1128	87/7206	0.024613899033
ko05133	Pertussis	6/1128	87/7206	0.024613899033
ko00260	Glycine, serine and threonine metabolism	2/1128	48/7206	0.0263192907382
ko04015	Rap1 signaling pathway	57/1128	278/7206	0.0282712939801
ko03018	RNA degradation	6/1128	84/7206	0.032984410225
ko04114	Oocyte meiosis	31/1128	139/7206	0.0337643648448
ko00640	Propanoate metabolism	1/1128	34/7206	0.0338856456868
ko00860	Porphyrin and chlorophyll metabolism	1/1128	34/7206	0.0338856456868
ko00500	Starch and sucrose metabolism	1/1128	35/7206	0.0338880335075
ko04115	p53 signaling pathway	5/1128	74/7206	0.0351729320087
ko04922	Glucagon signaling pathway	29/1128	128/7206	0.0359961588023
ko04620	Toll-like receptor signaling pathway	8/1128	100/7206	0.0364165359444
ko04217	Necroptosis	18/1128	178/7206	0.0368934590881
ko00561	Glycerolipid metabolism	4/1128	63/7206	0.0369367520025
ko04210	Apoptosis	18/1128	180/7206	0.0370738880528
ko05222	Small cell lung cancer	7/1128	89/7206	0.0397567062911
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1128	92/7206	0.0414965956599