ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1184	423/7206	5.66443780095e-47
ko04724	Glutamatergic synapse	88/1184	152/7206	8.06766278e-32
ko05033	Nicotine addiction	46/1184	56/7206	2.60140965105e-27
ko05032	Morphine addiction	67/1184	110/7206	3.02284356495e-26
ko04713	Circadian entrainment	75/1184	136/7206	2.17090813341e-25
ko04727	GABAergic synapse	64/1184	110/7206	1.47849459084e-23
ko04721	Synaptic vesicle cycle	53/1184	80/7206	1.6120993758e-23
ko04728	Dopaminergic synapse	85/1184	185/7206	1.47769655623e-21
ko04725	Cholinergic synapse	77/1184	160/7206	3.75731267824e-21
ko04723	Retrograde endocannabinoid signaling	77/1184	175/7206	3.01555603765e-18
ko04742	Taste transduction	39/1184	61/7206	8.0850802623e-17
ko04024	cAMP signaling pathway	102/1184	279/7206	1.08335865638e-16
ko04020	Calcium signaling pathway	98/1184	265/7206	1.61629543799e-16
ko04921	Oxytocin signaling pathway	83/1184	209/7206	2.92408288153e-16
ko04911	Insulin secretion	57/1184	117/7206	2.93717614595e-16
ko04726	Serotonergic synapse	62/1184	137/7206	1.25706747259e-15
ko04720	Long-term potentiation	45/1184	99/7206	9.01844485281e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1184	205/7206	1.13226368815e-11
ko05031	Amphetamine addiction	42/1184	91/7206	2.4299847638e-11
ko04970	Salivary secretion	43/1184	95/7206	3.12458692972e-11
ko03040	Spliceosome	1/1184	145/7206	1.92258021506e-10
ko04744	Phototransduction	22/1184	36/7206	1.70708163328e-09
ko04925	Aldosterone synthesis and secretion	41/1184	105/7206	2.49791131481e-08
ko04022	cGMP-PKG signaling pathway	67/1184	216/7206	6.43226485475e-08
ko04971	Gastric acid secretion	38/1184	98/7206	9.98672386538e-08
ko04360	Axon guidance	70/1184	233/7206	1.27746561937e-07
ko05203	Viral carcinogenesis	17/1184	277/7206	2.21684581355e-07
ko03013	RNA transport	7/1184	166/7206	1.28330043775e-06
ko04010	MAPK signaling pathway	86/1184	321/7206	1.4458068857e-06
ko04966	Collecting duct acid secretion	15/1184	26/7206	2.01010043226e-06
ko05168	Herpes simplex infection	9/1184	182/7206	2.36690571816e-06
ko04924	Renin secretion	32/1184	86/7206	2.61747916188e-06
ko05322	Systemic lupus erythematosus	6/1184	151/7206	3.39892727469e-06
ko04972	Pancreatic secretion	38/1184	111/7206	3.59297637449e-06
ko04060	Cytokine-cytokine receptor interaction	10/1184	191/7206	3.74682685725e-06
ko04070	Phosphatidylinositol signaling system	38/1184	112/7206	4.37686237523e-06
ko04740	Olfactory transduction	30/1184	80/7206	4.69762451194e-06
ko05164	Influenza A	8/1184	167/7206	6.34619005903e-06
ko04514	Cell adhesion molecules (CAMs)	42/1184	130/7206	6.45456327295e-06
ko05030	Cocaine addiction	28/1184	73/7206	7.11289268838e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1184	74/7206	8.67773511484e-06
ko04540	Gap junction	41/1184	128/7206	1.02268722824e-05
ko04621	NOD-like receptor signaling pathway	8/1184	157/7206	2.60136374316e-05
ko04730	Long-term depression	28/1184	78/7206	3.51367980782e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1184	79/7206	9.48310287476e-05
ko04110	Cell cycle	8/1184	145/7206	9.73377736769e-05
ko05110	Vibrio cholerae infection	23/1184	63/7206	0.000100202604148
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1184	59/7206	0.000111071939842
ko04745	Phototransduction - fly	16/1184	38/7206	0.000153418860164
ko04610	Complement and coagulation cascades	2/1184	79/7206	0.000172754487329
ko03008	Ribosome biogenesis in eukaryotes	2/1184	79/7206	0.000172754487329
ko04072	Phospholipase D signaling pathway	53/1184	197/7206	0.000182121526674
ko04976	Bile secretion	27/1184	80/7206	0.000183169598577
ko04141	Protein processing in endoplasmic reticulum	13/1184	184/7206	0.00024717270413
ko05414	Dilated cardiomyopathy	34/1184	112/7206	0.000248282721845
ko04120	Ubiquitin mediated proteolysis	8/1184	138/7206	0.000269039884676
ko04014	Ras signaling pathway	69/1184	279/7206	0.000271179349957
ko04750	Inflammatory mediator regulation of TRP channels	36/1184	122/7206	0.000285040429344
ko04964	Proximal tubule bicarbonate reclamation	13/1184	29/7206	0.000302346521925
ko05169	Epstein-Barr virus infection	16/1184	206/7206	0.000370542926532
ko04064	NF-kappa B signaling pathway	4/1184	96/7206	0.0004117085152
ko04260	Cardiac muscle contraction	30/1184	98/7206	0.000473348527616
ko04915	Estrogen signaling pathway	37/1184	131/7206	0.000737384402674
ko04146	Peroxisome	4/1184	89/7206	0.000822096303418
ko04371	Apelin signaling pathway	46/1184	177/7206	0.000958092977628
ko04626	Plant-pathogen interaction	9/1184	18/7206	0.00100032205097
ko04612	Antigen processing and presentation	3/1184	77/7206	0.00102774065096
ko05205	Proteoglycans in cancer	26/1184	271/7206	0.0014217395147
ko05140	Leishmaniasis	3/1184	75/7206	0.0014900826997
ko05162	Measles	8/1184	120/7206	0.00256926627725
ko00240	Pyrimidine metabolism	7/1184	110/7206	0.00258275633695
ko00330	Arginine and proline metabolism	2/1184	61/7206	0.00265759592031
ko04923	Regulation of lipolysis in adipocytes	23/1184	77/7206	0.0029090269808
ko05161	Hepatitis B	15/1184	173/7206	0.00356244704442
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1184	14/7206	0.00374456875299
ko03420	Nucleotide excision repair	1/1184	46/7206	0.00440955646996
ko04217	Necroptosis	16/1184	178/7206	0.00543638671206
ko00562	Inositol phosphate metabolism	25/1184	89/7206	0.0056012709885
ko00480	Glutathione metabolism	2/1184	55/7206	0.00566001974346
ko05321	Inflammatory bowel disease (IBD)	2/1184	56/7206	0.00573096075496
ko04640	Hematopoietic cell lineage	3/1184	64/7206	0.00643872761069
ko03022	Basal transcription factors	1/1184	44/7206	0.00671077489584
ko05144	Malaria	1/1184	45/7206	0.0070737440732
ko00071	Fatty acid degradation	1/1184	45/7206	0.0070737440732
ko05145	Toxoplasmosis	10/1184	126/7206	0.00729934003419
ko04270	Vascular smooth muscle contraction	38/1184	154/7206	0.00797520591331
ko00590	Arachidonic acid metabolism	2/1184	52/7206	0.00830210919299
ko04622	RIG-I-like receptor signaling pathway	3/1184	62/7206	0.00919675367753
ko04912	GnRH signaling pathway	31/1184	122/7206	0.00950246060792
ko00140	Steroid hormone biosynthesis	1/1184	41/7206	0.00993718133693
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1184	40/7206	0.00994452072374
ko00310	Lysine degradation	4/1184	73/7206	0.00996930878554
ko04916	Melanogenesis	35/1184	142/7206	0.0113570779387
ko04657	IL-17 signaling pathway	6/1184	87/7206	0.0127757331659
ko05133	Pertussis	6/1184	87/7206	0.0127757331659
ko05231	Choline metabolism in cancer	33/1184	134/7206	0.0131348653447
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1184	100/7206	0.0137587740963
ko03410	Base excision repair	1/1184	38/7206	0.0148132036207
ko03018	RNA degradation	6/1184	84/7206	0.0173730535288
ko00260	Glycine, serine and threonine metabolism	2/1184	48/7206	0.0176045676477
ko01524	Platinum drug resistance	5/1184	76/7206	0.0184391563166
ko04210	Apoptosis	18/1184	180/7206	0.0186166183587
ko04973	Carbohydrate digestion and absorption	13/1184	42/7206	0.019072341825
ko04710	Circadian rhythm	13/1184	43/7206	0.0215432213329
ko04922	Glucagon signaling pathway	31/1184	128/7206	0.021629338943
ko04975	Fat digestion and absorption	1/1184	35/7206	0.0221985165813
ko00982	Drug metabolism - cytochrome P450	1/1184	37/7206	0.0230220408919
ko04630	Jak-STAT signaling pathway	12/1184	132/7206	0.0234287277816
ko05131	Shigellosis	6/1184	82/7206	0.0236390891112
ko05166	HTLV-I infection	34/1184	292/7206	0.023774927987
ko04214	Apoptosis - fly	5/1184	72/7206	0.0250159091857
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1184	182/7206	0.0256187338095
ko04115	p53 signaling pathway	5/1184	74/7206	0.0256572570501
ko04062	Chemokine signaling pathway	45/1184	201/7206	0.0259537615666
ko00280	Valine, leucine and isoleucine degradation	3/1184	54/7206	0.0263580010329
ko04918	Thyroid hormone synthesis	22/1184	86/7206	0.0273829891288
ko05222	Small cell lung cancer	7/1184	89/7206	0.0296002204437
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1184	92/7206	0.0327762056831
ko03320	PPAR signaling pathway	5/1184	69/7206	0.0341952116979
ko04658	Th1 and Th2 cell differentiation	8/1184	96/7206	0.0360979153501
ko00983	Drug metabolism - other enzymes	2/1184	42/7206	0.0365879991309
ko04330	Notch signaling pathway	4/1184	62/7206	0.036806359568
ko04114	Oocyte meiosis	32/1184	139/7206	0.0376914773832
ko04930	Type II diabetes mellitus	15/1184	54/7206	0.0397282803193
ko04722	Neurotrophin signaling pathway	36/1184	160/7206	0.0403218538817
ko04620	Toll-like receptor signaling pathway	9/1184	100/7206	0.0415401226833
ko04510	Focal adhesion	28/1184	240/7206	0.0416466811609
ko04015	Rap1 signaling pathway	58/1184	278/7206	0.0473072342768
ko04711	Circadian rhythm - fly	5/1184	13/7206	0.0483194722263
ko05340	Primary immunodeficiency	1/1184	30/7206	0.0491112684442