ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	175/1098	423/7206	2.53695430486e-41
ko04724	Glutamatergic synapse	85/1098	152/7206	9.82690190715e-32
ko05033	Nicotine addiction	44/1098	56/7206	4.60128817246e-26
ko05032	Morphine addiction	63/1098	110/7206	1.57120604804e-24
ko04713	Circadian entrainment	70/1098	136/7206	2.07085807715e-23
ko04721	Synaptic vesicle cycle	51/1098	80/7206	4.54366592841e-23
ko04727	GABAergic synapse	60/1098	110/7206	6.46265933494e-22
ko04728	Dopaminergic synapse	80/1098	185/7206	1.9526109681e-20
ko04725	Cholinergic synapse	71/1098	160/7206	5.16149987019e-19
ko04723	Retrograde endocannabinoid signaling	73/1098	175/7206	1.13769649771e-17
ko04024	cAMP signaling pathway	95/1098	279/7206	1.31643829027e-15
ko04742	Taste transduction	36/1098	61/7206	4.22146291132e-15
ko04911	Insulin secretion	53/1098	117/7206	5.96616752743e-15
ko04020	Calcium signaling pathway	89/1098	265/7206	3.681411069e-14
ko04921	Oxytocin signaling pathway	74/1098	209/7206	2.39515272758e-13
ko04726	Serotonergic synapse	54/1098	137/7206	3.42973785916e-12
ko05031	Amphetamine addiction	39/1098	91/7206	1.91390040682e-10
ko04720	Long-term potentiation	41/1098	99/7206	2.37179894653e-10
ko04261	Adrenergic signaling in cardiomyocytes	67/1098	205/7206	2.91183485129e-10
ko04744	Phototransduction	22/1098	36/7206	3.85912606321e-10
ko04970	Salivary secretion	39/1098	95/7206	8.90342707574e-10
ko03040	Spliceosome	1/1098	145/7206	1.35214465149e-09
ko04360	Axon guidance	69/1098	233/7206	1.42356312048e-08
ko05168	Herpes simplex infection	6/1098	182/7206	2.94582257926e-07
ko04925	Aldosterone synthesis and secretion	37/1098	105/7206	3.06020847037e-07
ko05164	Influenza A	5/1098	167/7206	3.12654075051e-07
ko05203	Viral carcinogenesis	15/1098	277/7206	3.49161186024e-07
ko04966	Collecting duct acid secretion	15/1098	26/7206	7.43397773177e-07
ko04971	Gastric acid secretion	34/1098	98/7206	1.36756589485e-06
ko03013	RNA transport	6/1098	166/7206	1.78476723243e-06
ko05322	Systemic lupus erythematosus	5/1098	151/7206	3.03858971726e-06
ko04120	Ubiquitin mediated proteolysis	4/1098	138/7206	3.41747927898e-06
ko04740	Olfactory transduction	29/1098	80/7206	4.48276046994e-06
ko04022	cGMP-PKG signaling pathway	59/1098	216/7206	4.54294558578e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1098	74/7206	5.36014238124e-06
ko04514	Cell adhesion molecules (CAMs)	40/1098	130/7206	5.93330338868e-06
ko04621	NOD-like receptor signaling pathway	6/1098	157/7206	8.02899695408e-06
ko04972	Pancreatic secretion	35/1098	111/7206	1.27136538163e-05
ko05030	Cocaine addiction	26/1098	73/7206	1.85833167193e-05
ko04060	Cytokine-cytokine receptor interaction	10/1098	191/7206	2.23177313921e-05
ko04924	Renin secretion	29/1098	86/7206	2.46321742467e-05
ko04010	MAPK signaling pathway	77/1098	321/7206	3.11917344948e-05
ko04745	Phototransduction - fly	16/1098	38/7206	6.06053912932e-05
ko05110	Vibrio cholerae infection	22/1098	63/7206	0.000113584326448
ko04141	Protein processing in endoplasmic reticulum	11/1098	184/7206	0.000154974119589
ko04540	Gap junction	36/1098	128/7206	0.000157703542017
ko04730	Long-term depression	25/1098	78/7206	0.000177162616317
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1098	79/7206	0.000208256233056
ko04976	Bile secretion	25/1098	80/7206	0.000248041901419
ko05169	Epstein-Barr virus infection	14/1098	206/7206	0.000251313066531
ko04064	NF-kappa B signaling pathway	3/1098	96/7206	0.000259377931595
ko05205	Proteoglycans in cancer	21/1098	271/7206	0.000267160832436
ko04070	Phosphatidylinositol signaling system	32/1098	112/7206	0.000273978966855
ko04014	Ras signaling pathway	65/1098	279/7206	0.000326569549185
ko04110	Cell cycle	8/1098	145/7206	0.000400560059047
ko04610	Complement and coagulation cascades	2/1098	79/7206	0.000409315645834
ko03008	Ribosome biogenesis in eukaryotes	2/1098	79/7206	0.000409315645834
ko05161	Hepatitis B	11/1098	173/7206	0.000534654403634
ko04626	Plant-pathogen interaction	9/1098	18/7206	0.000565619902103
ko04260	Cardiac muscle contraction	28/1098	98/7206	0.000596389337041
ko04072	Phospholipase D signaling pathway	48/1098	197/7206	0.0005992500605
ko04964	Proximal tubule bicarbonate reclamation	12/1098	29/7206	0.000615034716621
ko04612	Antigen processing and presentation	2/1098	77/7206	0.000615985717187
ko05162	Measles	6/1098	120/7206	0.000739776426007
ko05414	Dilated cardiomyopathy	31/1098	112/7206	0.000756426032353
ko05140	Leishmaniasis	2/1098	75/7206	0.000938608914914
ko04750	Inflammatory mediator regulation of TRP channels	32/1098	122/7206	0.00137012374142
ko04371	Apelin signaling pathway	43/1098	177/7206	0.00137246515871
ko05166	HTLV-I infection	26/1098	292/7206	0.0015091685227
ko00480	Glutathione metabolism	1/1098	55/7206	0.00208644318342
ko04146	Peroxisome	4/1098	89/7206	0.002596172406
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1098	59/7206	0.00285996597822
ko04915	Estrogen signaling pathway	33/1098	131/7206	0.00291911140685
ko00590	Arachidonic acid metabolism	1/1098	52/7206	0.00311578372065
ko04210	Apoptosis	14/1098	180/7206	0.00316564198123
ko01524	Platinum drug resistance	3/1098	76/7206	0.00335140760291
ko04214	Apoptosis - fly	3/1098	72/7206	0.00474680580034
ko00330	Arginine and proline metabolism	2/1098	61/7206	0.00619889203907
ko04668	TNF signaling pathway	8/1098	120/7206	0.00665904283614
ko03420	Nucleotide excision repair	1/1098	46/7206	0.00698111892748
ko00240	Pyrimidine metabolism	7/1098	110/7206	0.00698118924684
ko05145	Toxoplasmosis	9/1098	126/7206	0.0082804942172
ko04630	Jak-STAT signaling pathway	10/1098	132/7206	0.0101430976606
ko03022	Basal transcription factors	1/1098	44/7206	0.0104213516986
ko05144	Malaria	1/1098	45/7206	0.0106938216496
ko00071	Fatty acid degradation	1/1098	45/7206	0.0106938216496
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1098	14/7206	0.0123558641788
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1098	92/7206	0.0125995750854
ko00280	Valine, leucine and isoleucine degradation	2/1098	54/7206	0.0126410319055
ko05321	Inflammatory bowel disease (IBD)	2/1098	56/7206	0.0133558095189
ko04640	Hematopoietic cell lineage	3/1098	64/7206	0.0137332869827
ko04923	Regulation of lipolysis in adipocytes	20/1098	77/7206	0.0153447292611
ko00140	Steroid hormone biosynthesis	1/1098	41/7206	0.0154978865007
ko05131	Shigellosis	5/1098	82/7206	0.0192527139168
ko04217	Necroptosis	16/1098	178/7206	0.0195435042466
ko04330	Notch signaling pathway	3/1098	62/7206	0.0196124881466
ko04622	RIG-I-like receptor signaling pathway	3/1098	62/7206	0.0196124881466
ko04930	Type II diabetes mellitus	15/1098	54/7206	0.0201018428518
ko00310	Lysine degradation	4/1098	73/7206	0.0202569976573
ko04270	Vascular smooth muscle contraction	34/1098	154/7206	0.022744447557
ko04114	Oocyte meiosis	31/1098	139/7206	0.0233605376571
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1098	100/7206	0.0236470605628
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1098	40/7206	0.0241089594363
ko05222	Small cell lung cancer	6/1098	89/7206	0.0247692963447
ko00260	Glycine, serine and threonine metabolism	2/1098	48/7206	0.0263718274548
ko05219	Bladder cancer	2/1098	48/7206	0.0263718274548
ko00380	Tryptophan metabolism	2/1098	50/7206	0.0272244186277
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1098	182/7206	0.0275282831038
ko05215	Prostate cancer	9/1098	111/7206	0.0329535301903
ko04916	Melanogenesis	31/1098	142/7206	0.0332210354594
ko04657	IL-17 signaling pathway	6/1098	87/7206	0.0339037372283
ko05133	Pertussis	6/1098	87/7206	0.0339037372283
ko04975	Fat digestion and absorption	1/1098	35/7206	0.0342738435018
ko00500	Starch and sucrose metabolism	1/1098	35/7206	0.0342738435018
ko04510	Focal adhesion	25/1098	240/7206	0.0352769507309
ko00982	Drug metabolism - cytochrome P450	1/1098	37/7206	0.0352991773516
ko00562	Inositol phosphate metabolism	21/1098	89/7206	0.0363761312896
ko00620	Pyruvate metabolism	2/1098	46/7206	0.0379855728551
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1098	135/7206	0.0392068570376
ko04912	GnRH signaling pathway	27/1098	122/7206	0.0410871029381
ko03018	RNA degradation	6/1098	84/7206	0.045183461855
ko04620	Toll-like receptor signaling pathway	8/1098	100/7206	0.0483431109255
ko04115	p53 signaling pathway	5/1098	74/7206	0.0488892754494