ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1241	423/7206	2.34214084908e-44
ko04724	Glutamatergic synapse	91/1241	152/7206	8.13907363014e-33
ko05033	Nicotine addiction	47/1241	56/7206	9.12413459847e-28
ko05032	Morphine addiction	67/1241	110/7206	5.15861729086e-25
ko04721	Synaptic vesicle cycle	55/1241	80/7206	1.49516874926e-24
ko04713	Circadian entrainment	75/1241	136/7206	4.65958958222e-24
ko04727	GABAergic synapse	65/1241	110/7206	2.95720052626e-23
ko04725	Cholinergic synapse	76/1241	160/7206	3.37672845706e-19
ko04728	Dopaminergic synapse	83/1241	185/7206	6.53734620144e-19
ko04020	Calcium signaling pathway	101/1241	265/7206	1.4836741276e-16
ko04723	Retrograde endocannabinoid signaling	76/1241	175/7206	1.99364481404e-16
ko04024	cAMP signaling pathway	104/1241	279/7206	2.75007942767e-16
ko04911	Insulin secretion	57/1241	117/7206	2.61160048369e-15
ko04742	Taste transduction	38/1241	61/7206	3.59592616702e-15
ko04921	Oxytocin signaling pathway	83/1241	209/7206	4.76090539509e-15
ko04744	Phototransduction	26/1241	36/7206	4.74575055853e-13
ko04726	Serotonergic synapse	59/1241	137/7206	7.88688360027e-13
ko04720	Long-term potentiation	47/1241	99/7206	2.49812865791e-12
ko04970	Salivary secretion	44/1241	95/7206	3.57921660423e-11
ko03040	Spliceosome	1/1241	145/7206	4.36317362448e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1241	205/7206	4.91861539465e-11
ko05031	Amphetamine addiction	42/1241	91/7206	1.1534357716e-10
ko04360	Axon guidance	76/1241	233/7206	5.43908124318e-09
ko04740	Olfactory transduction	35/1241	80/7206	2.32052200468e-08
ko04022	cGMP-PKG signaling pathway	70/1241	216/7206	3.73430872218e-08
ko05203	Viral carcinogenesis	17/1241	277/7206	3.79472533245e-08
ko05168	Herpes simplex infection	7/1241	182/7206	4.04535146242e-08
ko04971	Gastric acid secretion	39/1241	98/7206	9.48471332086e-08
ko04925	Aldosterone synthesis and secretion	40/1241	105/7206	2.88638640841e-07
ko03013	RNA transport	7/1241	166/7206	3.81613059967e-07
ko05164	Influenza A	7/1241	167/7206	3.84177975471e-07
ko04966	Collecting duct acid secretion	16/1241	26/7206	5.13608390087e-07
ko04540	Gap junction	44/1241	128/7206	2.35426634487e-06
ko04060	Cytokine-cytokine receptor interaction	11/1241	191/7206	3.5818991928e-06
ko04924	Renin secretion	33/1241	86/7206	3.74756475398e-06
ko05030	Cocaine addiction	29/1241	73/7206	5.03036274395e-06
ko05169	Epstein-Barr virus infection	13/1241	206/7206	5.25554087831e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1241	74/7206	6.41057492923e-06
ko04260	Cardiac muscle contraction	35/1241	98/7206	9.35813140981e-06
ko05322	Systemic lupus erythematosus	8/1241	151/7206	1.62486332671e-05
ko04010	MAPK signaling pathway	85/1241	321/7206	2.02551371094e-05
ko04514	Cell adhesion molecules (CAMs)	42/1241	130/7206	2.88713933519e-05
ko04120	Ubiquitin mediated proteolysis	7/1241	138/7206	3.07254700203e-05
ko04141	Protein processing in endoplasmic reticulum	13/1241	184/7206	6.67379066809e-05
ko04745	Phototransduction - fly	17/1241	38/7206	6.97318135466e-05
ko04610	Complement and coagulation cascades	2/1241	79/7206	7.10150550053e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1241	79/7206	7.10150550053e-05
ko05162	Measles	6/1241	120/7206	7.87881775601e-05
ko04621	NOD-like receptor signaling pathway	10/1241	157/7206	9.72207108795e-05
ko04972	Pancreatic secretion	36/1241	111/7206	0.000106547091281
ko04371	Apelin signaling pathway	51/1241	177/7206	0.000108675110162
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1241	79/7206	0.000116802876181
ko04110	Cell cycle	9/1241	145/7206	0.000131374400932
ko05140	Leishmaniasis	2/1241	75/7206	0.000159413314596
ko04064	NF-kappa B signaling pathway	4/1241	96/7206	0.000181339258233
ko04730	Long-term depression	27/1241	78/7206	0.000204261860068
ko05205	Proteoglycans in cancer	25/1241	271/7206	0.000204645899074
ko05414	Dilated cardiomyopathy	35/1241	112/7206	0.000218243187623
ko04070	Phosphatidylinositol signaling system	35/1241	112/7206	0.000218243187623
ko04014	Ras signaling pathway	72/1241	279/7206	0.000249915571449
ko04626	Plant-pathogen interaction	10/1241	18/7206	0.000253996499232
ko05110	Vibrio cholerae infection	23/1241	63/7206	0.000275644859047
ko04976	Bile secretion	27/1241	80/7206	0.000280551310107
ko00480	Glutathione metabolism	1/1241	55/7206	0.000536086293556
ko04146	Peroxisome	4/1241	89/7206	0.000555280536356
ko04612	Antigen processing and presentation	3/1241	77/7206	0.000674427021046
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1241	59/7206	0.000701334624206
ko05161	Hepatitis B	14/1241	173/7206	0.000704344593939
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1241	14/7206	0.000851513235742
ko04072	Phospholipase D signaling pathway	52/1241	197/7206	0.001058472028
ko00590	Arachidonic acid metabolism	1/1241	52/7206	0.00126903049609
ko00240	Pyrimidine metabolism	7/1241	110/7206	0.00129181664315
ko04915	Estrogen signaling pathway	37/1241	131/7206	0.00147795511784
ko04750	Inflammatory mediator regulation of TRP channels	35/1241	122/7206	0.00149805719829
ko04964	Proximal tubule bicarbonate reclamation	12/1241	29/7206	0.00188076430493
ko03420	Nucleotide excision repair	1/1241	46/7206	0.00279787377562
ko04668	TNF signaling pathway	9/1241	120/7206	0.00314717300185
ko01524	Platinum drug resistance	4/1241	76/7206	0.00328430353879
ko05166	HTLV-I infection	32/1241	292/7206	0.0032947429315
ko05321	Inflammatory bowel disease (IBD)	2/1241	56/7206	0.00376602574671
ko05145	Toxoplasmosis	10/1241	126/7206	0.00397883550363
ko03022	Basal transcription factors	1/1241	44/7206	0.00424135515092
ko00071	Fatty acid degradation	1/1241	45/7206	0.0044192436304
ko00310	Lysine degradation	4/1241	73/7206	0.00463714740377
ko00330	Arginine and proline metabolism	3/1241	61/7206	0.00621315332905
ko04622	RIG-I-like receptor signaling pathway	3/1241	62/7206	0.00621352096214
ko00140	Steroid hormone biosynthesis	1/1241	41/7206	0.00636246287064
ko00380	Tryptophan metabolism	2/1241	50/7206	0.00798727534329
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1241	40/7206	0.00989554320774
ko04912	GnRH signaling pathway	32/1241	122/7206	0.0108117404534
ko04620	Toll-like receptor signaling pathway	8/1241	100/7206	0.0109601733415
ko03018	RNA degradation	6/1241	84/7206	0.0125636043449
ko04115	p53 signaling pathway	5/1241	74/7206	0.0128414438533
ko04922	Glucagon signaling pathway	33/1241	128/7206	0.012842523095
ko04923	Regulation of lipolysis in adipocytes	22/1241	77/7206	0.0140040429531
ko00982	Drug metabolism - cytochrome P450	1/1241	37/7206	0.0145129775998
ko00630	Glyoxylate and dicarboxylate metabolism	1/1241	38/7206	0.0152026750856
ko03410	Base excision repair	1/1241	38/7206	0.0152026750856
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1241	100/7206	0.0154121567537
ko05144	Malaria	2/1241	45/7206	0.0170146788715
ko04270	Vascular smooth muscle contraction	38/1241	154/7206	0.0172432303944
ko05131	Shigellosis	6/1241	82/7206	0.0173881061424
ko04214	Apoptosis - fly	5/1241	72/7206	0.0177769799979
ko00280	Valine, leucine and isoleucine degradation	3/1241	54/7206	0.0180980849873
ko00600	Sphingolipid metabolism	4/1241	63/7206	0.0182261972516
ko04658	Th1 and Th2 cell differentiation	8/1241	96/7206	0.0197965586108
ko04657	IL-17 signaling pathway	7/1241	87/7206	0.0214071742589
ko05133	Pertussis	7/1241	87/7206	0.0214071742589
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1241	182/7206	0.0220915560987
ko00562	Inositol phosphate metabolism	24/1241	89/7206	0.022551342422
ko04916	Melanogenesis	35/1241	142/7206	0.0240849016852
ko05418	Fluid shear stress and atherosclerosis	19/1241	173/7206	0.0250404223912
ko04330	Notch signaling pathway	4/1241	62/7206	0.0261959661531
ko04630	Jak-STAT signaling pathway	13/1241	132/7206	0.0261967033645
ko05206	MicroRNAs in cancer	20/1241	177/7206	0.0340641624571
ko05217	Basal cell carcinoma	5/1241	68/7206	0.0340943678662
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1241	92/7206	0.0356486056084
ko00983	Drug metabolism - other enzymes	2/1241	42/7206	0.0371930342344
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1241	135/7206	0.0374170296487
ko05212	Pancreatic cancer	7/1241	83/7206	0.0390183534227
ko05215	Prostate cancer	11/1241	111/7206	0.0418806902613
ko04015	Rap1 signaling pathway	61/1241	278/7206	0.0423775081581
ko04640	Hematopoietic cell lineage	5/1241	64/7206	0.0453791453673
ko04210	Apoptosis	21/1241	180/7206	0.0454867402132
ko04930	Type II diabetes mellitus	15/1241	54/7206	0.0462776903367
ko05320	Autoimmune thyroid disease	1/1241	29/7206	0.0480019859451